Bioinformatic analysis refers to the use of computer algorithms and techniques to study and understand biological data. It involves the processing and interpretation of large amounts of information, such as DNA sequences or protein structures, to extract meaningful insights and patterns. In other words, it's using computers to analyze biological data and find answers to biological questions.
Full definition
Using mass spectrometry and
bioinformatic analysis in close cooperation with the Core Facility Proteomics of the Helmholtz Zentrum München and the Bioinformatics and Computational Biology Department of the Technische Universität München, the researchers succeeded in precisely identifying a multitude of surface proteins.
The title of the paper is «
Bioinformatic analysis reveals a pattern of STAT3 - associated gene expression specific to basal - like breast cancers in human tumors.»
The
necessary bioinformatic analyses were performed by experts from the University of Shanghai and from the team of Georg Haberer from the Helmholtz Center Munich.
Bioinformatic analyses suggest that glycine - arginine and proline - arginine repeats could mimic the nuclear localization signals of these proteins and hence hijack nuclear import by overloading the nucleocytoplasmic transport system.
• Mouse whole genome scanning The unit offers microsatellite and SNP based Genome Scanning Services for gene identification projects, based on linkage analysis, offering coverage for a number of mouse strains (i.e. C57BL6, DBA2J, CBA, 129S6, 129P2), as well
as bioinformatic analysis using suitable mouse genetic software.
Relevant publications: (1) Drug repurposing, computer - based screening (2) Functional testing and novel tools for bioapplications (3) Therapeutic targets and disease pathways by bioinformatic analysis
In 2014 the CNAG - CRG together with CIBERER launched a call to the Spanish research community offering free - of - charge Whole Exome Sequencing and
bioinformatic analysis for disease gene identification in rare disorders.
Wednesday, Oct. 18, 9:00 - 10:30 a.m., Room 330C, South Building Platform Session: Landscape of Cancer:
Bioinformatic Analyses Moderators: Lisa Mirabello, National Cancer Institute; and Daniel Schaid, Mayo Clinic
Permission of the principal investigator should be obtained before publishing
solely bioinformatic analyses (e.g. metabolic reconstruction, synteny) of unpublished sequence / open reading frames / genes on a chromosome - or genome - wide scale.
First, samples of leaves from these plants are collected for in vitro cultures to isolate the fungi; then the DNA and RNA of fungi are extracted to sequence them and,
through bioinformatic analysis, the researcher can determine the expression, the presence or absence of genes in the genomes of a species against each other.
The students have undergone a comprehensive education in life science emphasising cutting - edge methods in
bioinformatic analysis of big data, high throughput techniques of molecular biology as well as how to translate biological findings into diagnostic tools and novel treatments.
The researchers employed an integrative approach that combined in vitro drug testing with proteomic and
bioinformatic analysis.
Bioinformatic analysis of this sequence information was then able to pinpoint a gene that might have the appropriate activity to initiate hydrocarbon biosynthesis, Molnar said.
In addition to Tsagaratou and González - Avalos, Sini Rautio of Aalto University School of Science, in Aalto, Finland, was a co-second author of the paper, contributing significantly to
the bioinformatic analysis of genome - wide sequencing data.
To do so, we will combine human OSCC samples and metastatic orthotopic mouse models, with state - of - the - art quantitative transcriptomic, proteomic, metabolomic, and
bioinformatic analyses to identify the effect of different dietary fatty acids in metastatic progression.
This understanding can be gained from studies of model organisms, in vitro experiments,
bioinformatic analyses and human genetic studies.
The bioinformatic analysis and interpretation strategies look solid.
His lab uses electrophysiology, confocal imaging, single neuron RNAseq, and
bioinformatic analysis to compare homologous neurons and the neural circuits that they form.
Depends on needs of user: typically RNAseq and / or
bioinformatic analysis of data from 1 clinical sample.
Another way to go is
bioinformatic analysis of individual protein - altering (nonsynonymous) mutations to score their probable effect on the protein.