Sentences with phrase «biological targets»

The ultimate goal is to provide new biological targets for medication.

The problem is that the sometimes a drug blocks a specific biological target that's important for normal functioning in other places within the body.

Fluorine - 18 is a popular tracer for revealing cancers and other biological targets in PET scans.

The ultimate goal is to increase the number of new diagnostics and therapies for patients while reducing the time and cost of developing them, by jointly identifying and validating promising biological targets for several diseases, including type 2 diabetes.

A team at Rockefeller University and Rensselaer Polytechnic Institute is developing a system that would make it possible to remotely control biological targets in living animals — rapidly, without wires, implants or drugs.

The reason for such limited success, argue Drs. Mahley and Huang, is that researchers aren't examining all potential biological targets.

Johns Hopkins researchers along with academic and drug industry investigators say they have identified a new biological target for treating spinal muscular atrophy.

Several other drugs that inhibit the same biological target had already been approved for frontline CML treatment.

«Alcohol prevents ability to extinguish fearful memories in mice: Insight into cellular mechanisms illuminates biological target for PTSD therapy.»

Reactivation of HBV may occur with chemotherapy, organ and tissue transplantation, High dose corticosteroids, and biologicals targeting tumor necrosis factor - alpha (TNF - α), Anti-TNF medications are used in treating rheumatic diseases, such as rheumatoid arthritis, digestive conditions that include Crohn's and colitis, and dermatologic conditions, such as psoriasis.

Special computational techniques are also available to discover biological targets (proteins, nucleic acids) of a drug.

The research group is now working on developing safer and smarter multitasking contrast agents, which can simultaneously record and interpret multiple biological targets, and eventually allow a better understanding of biological processes and accurate diagnosis of diseases.

«We can use this to identify biological targets that we can potentially manipulate to effect a rescue,» said Eric James, a Brown University graduate student and lead author of a paper describing the research in the Journal of Neuroscience.

The limited resources of time - consuming and expensive laboratory experiments including the development of a synthesis protocol as well as in vitro and in vivo tests for toxicity quantification can then be restricted on metabolites that are most likely to affect critical biological targets.

At a meeting last month just outside Boston, chemists and biologists discussed the promise of DNA - encoded chemical libraries (DELs), which rely on the unique talents of DNA to track, select, and even synthesize compounds that bind to enzymes, receptors, and other biological targets.

In 2017, AstraZeneca struck a partnership with BERG, a Massachusetts startup, to use the latter's A.I. platform to home in on promising biological targets and possible agents against neurological diseases such as Parkinson's.

«Ideally, we'd partner with a group that has a specific biological target or drug candidate of interest that contains a CF3,» and work to adapt the gold complex his team used in the latest study to the specific application, he added.

Evaluate the potential therapeutic opportunities — and to elaborate upon the potential biological targets — to treat dormant MRD in different cancers.

They analyze huge chemical, biological and medical databases, alongside reams of scientific papers, far quicker than humanly possible, throwing up new biological targets and potential drugs.

But because the new DNA objects are on the same size scale of devices that can be patterned using computer chip lithography, it might be possible to integrate the two technologies and design DNA origami to detect cancer biomarkers and other biological targets that could then be read out by electronic devices, Castro says.

«This is crucial in investigating covalent inhibitors, which react with their biological targets, and are the focus of growing interest in the pharmaceutical industry.»

To narrow down the number of chemical compounds that could be potential drug candidates, scientists utilize computer models that can predict how a particular chemical compound might interact with a biological target of interest — for example, a key protein that might be involved with a disease process.

A major advantage of in vivo imaging by fluorescence tomography is that it enables the study of biological targets and pathways in context and in their natural state.

In order to prioritize these hits compounds for the development of probe or lead molecules it is critical to determine their mode of action, i.e. the biological target protein.

With the advancement in radiation treatment modalities, by precise physical and biological targeting, cancer could be more effectively treated with radiation therapy with minimal normal tissue damaging [1].