«This remodeling process
of the cell proteome by autophagy is an important immune - suppressive survival mechanism for Ras - driven
cancers, and inhibiting autophagy can provide a means to target these
aggressive cancers,» notes White, who is also a distinguished professor
of molecular
biology and biochemistry at Rutgers School
of Arts and Sciences.
«In addition to having a higher prevalence
of triple - negative breast
cancers than Caucasian women — something that has been documented in previous studies — we found that African American women with breast
cancer had a significantly higher prevalence of the TP53 driver mutation, basal tumor subtype and greater genomic diversity within tumors, all of which suggest more aggressive tumor biology,» says Tanya Keenan, MD, of the MGH Cancer Center, lead author of the
cancer had a significantly higher prevalence
of the TP53 driver mutation, basal tumor subtype and greater genomic diversity within tumors, all
of which suggest more
aggressive tumor
biology,» says Tanya Keenan, MD,
of the MGH
Cancer Center, lead author of the
Cancer Center, lead author
of the study.