For cell therapy, automation can be used to increase the scale of cell
culture operations (e.g.,
bioreactors replacing flasks) and allow the use of closed
systems that can protect cell products from contamination with adventitious agents from the environment or operators themselves.
Viral Manufacturing To manufacture viral vectors, two approaches generally are adopted for
culturing purposes: scale - out of adherent - cell
systems based on 2D planar technologies and scale - up of 3D suspension cell
cultures in stirred - tank
bioreactors.