Sentences with word «bispecific»
The word "bispecific" means something that can bind to and interact with two different things at the same time. Full definition
Slava Stamova (Rieber, TUD)-- «Polyclonal tumor - specific activation of cytotoxic effector cells by bispecific antibody constructs» (2009)
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The drug, manufactured by Amgen, is the first of a novel class of agents known as bispecific T cell engagers (BiTE), which consist of essentially two monoclonal antibodies joined together.
But this new work ups the ante by designing so - called bispecific antibodies that both promise to reverse latency and then do the mop - up work.
Aside of conventional bispecific antibodies and antigen specific chimeric antigen receptors (CARs) for retargeting of T cells e. g. to prostate cancer or leukemic cells we have developed a novel and unique modular cell targeting system allowing us to target any kind of antigen.
CD3 (cluster of differentiation 3) is a common target for bispecific antibodies.
But the arms of bispecific antibodies each grab a unique protein.
• EpimAb Biotherapeutics, a Shanghai - based biotech company specializing in bispecific antibodies, raised $ 25 million in Series A. Oriza Seed Capital led the round, and was joined by Decheng Capital, 3E Bioventures Capital and Trend Investment Group.
GT's lead oncology drug candidate, OXS - 1550 (DT2219) is a novel bispecific scFv recombinant fusion protein - drug conjugate composed of the variable regions of the heavy and light chains of anti-CD19 and anti-CD22 antibodies and a modified form of diphtheria toxin as its cytotoxic drug payload.
He further points out that two cancer bispecific antibodies on the market both have anti-CD3 arms.
David Margolis, a virologist at the University of North Carolina, Chapel Hill, and co-author of the JCI study, says draining a reservoir ultimately may require combining bispecific antibodies with other latency reversing approaches and immune system stimulators like anti-HIV vaccines.
But the anti-CD3 antibodies in the earlier study had both arms, Mascola notes, which led to far more activation than the single arm in the new bispecific antibodies.
These fCD8 + cells have cytolytic potential and can be redirected to target and kill HIV - infected cells using bispecific antibodies.
Altogether, our data support the use of SIV infection to better understand the dynamics of fCD8 + cells and to develop bispecific antibodies as a strategy for virus eradication.
Arndt, C., von Bonin, M., Cartellieri, M., Feldmann, A., Koristka, S., Michalk, I., Stamova, S., Bornhäuser, M., Ehninger, G. and Bachmann, M. Redirection of T cells with a first fully humanized bispecific CD33 - CD3 antibody efficiently eliminates AML blasts without harming hematopoietic stem cells.Leukemia, doi: 10.1038 / leu.2013.18.
Two of our conventional bispecific abs (CD3 - CD33 and CD3 - PSCA) are presently on the way to be translated into the clinic.
The modular system bases on replacable target modules which can be combined with either bispecific universal effector modules or a universal CAR.
Tags for this Online Resume: Research, Protein purification, Protein analytics, Test, Antibody, monospecific bispecific, purification, TCR - Ig, DVD - Ig, High throughput assays, Enzyme assays, Data Analysis, Biochemical and biophysical assays, UV, VIS, ITC, DSC, SEC MALS, Fluorescence, Pymol, Modeller, CCP4 suite
GT Biopharma, Inc. is an immuno - oncology biotechnology company focused on innovative treatments based on the company's proprietary Tri and Tetra - specific Natural Killer Cell Engagers (TriKEs ™ and TetraKEs) and bispecific antibody - drug conjugate (ADC) platforms.
Xencor (XNCR)- The company announced intriguing preclinical data on XmAb24306, an IL15 / IL15 - receptor alpha complex fused to a bispecific XmAb Fc domain (IL15 / IL15Rα - Fc) for the treatment of multiple oncology indications.
Those candidates include antibodies that would activate and arm more T cells and bispecific, engineered antibodies that physically bring T cells to the tumor cells they are armed to kill.
The bispecific antibodies focus on the CD3 receptor for two reasons.
Now, the bispecific antibody grabs a killer T cell that has a CD3 receptor and, with its second arm, finds a recently activated cell that has HIV proteins on its surface.
Last week, researchers at Albert Einstein College of Medicine in New York reported that «bispecific» monoclonal antibodies they engineered to recognize two species of Ebola virus provided a high degree of protection in mice exposed to two Ebola viral species.
But neither team has yet shown that their bispecific antibodies can actually reduce reservoirs of HIV in monkeys, which are commonly used to study the AIDS virus.
The bispecific antibody first binds to CD3 on cells that harbor latent HIV.
Midori Shima, director of the Hemophilia Center at Nara Medical University in Japan, has created a «bispecific» antibody to do the same job.
The bispecific antibody has a half - life of about 30 days, much longer than the 12 - hour upper limit of factor VIII, Shima says.
«Trispecific antibodies engage a broader range of viral particles than do monospecific and bispecific antibodies,» said J. Victor Garcia, Ph.D., article co-author and a professor of medicine at UNC.
«That bispecific antibody would be hugely disruptive if it works,» he says.
To create a longer - lasting preventive therapy for severe hemophilia A-associated bleeding, a group of Japanese researchers launched a first - in - human Phase I trial to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of ACE910, a bispecific antibody that mimics FVIII and works with other clotting factors to make the blood clot properly.
Blincyto is a special type of monoclonal antibody called a bispecific T cell engager (BiTE), consisting of two monoclonal antibodies joined together.