Sentences with word «bisphosphonate»

They include the use of bisphosphonate drugs to reduce the weakening of bone and the surgical implantation of steel rods in the bones to improve their strength.

Approximately 40 % of the patients received concomitant treatment with bisphosphonates.

The technicians at Diagnostic Radiology Associates in Waterbury were so astonished that they wanted to know how I did it without the use of bisphosphonate drug.

Most existing therapies such as bisphosphonate drugs reduce the rate of bone loss, but they do not promote new bone growth.

Several years ago, chemist John Frangioni and his colleagues at Harvard Medical School in Boston, Massachusetts, began linking different imaging molecules called contrast agents to bisphosphonate in hopes that they could use the drug to target the contrast agents to the tumors.

An indication of a minor added benefit of radium - 223 can be derived for patients older than 65 years without concomitant bisphosphonate treatment.

A newly published International Osteoporosis Foundation (IOF) and European Calcified Tissue Society (ECTS) Working Group position paper [1] proposes measuring specific bone turnover markers (BTMs) in patients who have initiated use of oral bisphosphonates for postmenopausal osteoporosis as a clinically feasible and practical way to identify low adherence.

Bisphosphonates such as Fosamax and Boniva inhibit normal remodeling of bone, which results in unhealthy, brittle bone and can result in osteonecrosis.Decreased bone density is of great concern as one of the leading causes of frailty among aging women and men.

But researchers have known for years that an osteoporosis drug called bisphosphonate can, as it binds to hydroxyapetite.

Professor Adolfo Diez - Perez, Co-Chair of the Joint IOF - ECTS Adherence Working Group, stated, «The use of bone turnover marker measurement to detect a lack of response to oral bisphosphonates is a practical and low - cost screening procedure which helps identify potential non-adherence in patients very early after treatment initiation.

Over the years, hundreds of plaintiffs have filed their dangerous drug lawsuits for complications caused by bisphosphonates.

For those taking bisphosphonate medications, the rate of hip fractures was 86 per 1,000 patients — higher than the combined rate for those who underwent surgery or did nothing at all.

They settled on bisphosphonates, which have already been approved by the Food and Drug Administration (FDA) to battle osteoporosis, a bone - thinning disease.

Depending on the patients» age and the concomitant treatment (with / without bisphosphonates), there is an indication of major and an indication of minor added benefit of radium - 223 compared with best supportive care (BSC).

Bisphosphonates keep bones strong by slowing the breakdown of bone.

We found the doctor had little interest in the clinical management of pediatric OI patients and knew little of bisphosphonate pharmacology.

She led some of the first work on the role of weight - bearing exercise in building and maintaining bone mass and studied bisphosphonates as an osteoporosis treatment.

Robert Coleman from the University of Sheffield, UK, says we had assumed that bisphosphonates simply wouldn't get into tumours other than bone cancers at any concentration that could make a difference.

«This exciting paper presents a potential mechanism by which bisphosphonates could get to the breast in reasonable quantities,» Coleman says.

To see if bisphosphates are reacting with the breast calcium, Mike Rogers from the Garvan Institute in Sydney, Australia, and colleagues tagged bisphosphonate molecules with a chemical that glows under a microscope.

Yeh said more research is needed to see if bisphosphonates also increase the risk for fractures for people with underlying causes of osteoporosis other than hyperparathyroidism.

«These findings should make bisphosphonates less attractive as an alternative to parathyroid surgery in patients with primary hyperparathyroidism.»

Xia Y, Liu Y - L, Xie Y, Zhu W, Guerra F, Shen S, Yeddula N, Fischer W, Low W, Zhou X, Zhang Y, Oldfield E, Verma IM (2014) A combination therapy for KRAS - driven lung adenocarcinomas using lipophilic bisphosphonates and rapamycin.

The structures aided us in formulating an explanation for this mechanistic disparity, and also revealed how each enzyme interacted differently with bisphosphonates [Artz et al, Chem.

Symptoms of hypercalcemia can be controlled with fluid therapy and prednisone or calcium lowering drugs (e.g. bisphosphonates).

When amputation or partial unlectomy are not good options for the patient, radiation therapy and bisphosphonate therapy can control pain, improve and lengthen quality of life for several months.

Her graduate research focused on the design and synthesis of novel bisphosphonates for their applications as fluorescent drug probes and as potential dental adhesives.

The FDA also found that after conducting its own review of how effective bisphosphonates are after several years of use, beyond three to five years there was little, if any, additional benefit for most patients unless the person was older and had a higher fracture risk and a bone density that was «osteoporotic.»

The reason bisphosphonates are often prescribed to women is that after age 30 it is not uncommon for their bones to begin dissolving faster than they can be rebuilt - especially after menopause.

Earlier this year, the US Food and Drug Administration published an analysis in the New England Journal of Medicine that warned about taking bisphosphonates long - term.

• 44 % of 71 participants kept taking bisphosphonates even after suffering a break.

• 94 % of participants had used only Fosamax and no other bisphosphonate.

Most bisphosphonates are used to treat bone disorders, so that they cause bone breaks and other serious side effects, including osteocronosis of the jaw, is horribly unacceptable.

Doctors commonly treat hyperparathyroidism using a class of prescription drugs called bisphosphonates, including alendronate (marketed under the brand name Fosamax) and ibandronate (Boniva), which are supposed to strengthen bones.

In particular, these include adequate pain therapy, treatment with bisphosphonates and / or radionuclides.

The researchers also reviewed the number of bone fractures of all types (including hip fractures), and the results were similar: For people who did not receive treatment, there were 206 fractures per 1,000; for those who had surgery, 157 fractures per 1,000; and for those taking bisphosphonate medications, 303 fractures per 1,000.

Oral bisphosphonates are common first line treatments for osteoporosis.

Drug interactions: Calcium can interfere with many medications, including prescription osteoporosis drugs known as bisphosphonates (such as alendronate), certain blood pressure medications, antibiotics in the tetracycline and quinolone families (like Cipro); and levothyroxine, which treats hypothyroidism.

Fosamax is the brand name for alendronate, a type of bisphosphonate drug that is manufactured by Merck & Co..

«I envision a treatment that uses a precise combination of sclerostin antibodies to grow new bone, followed by bisphosphonates to lock in that bone growth,» said Michelle Caird, associate professor of orthopaedic surgery who specializes in brittle bone disease.

The average participant had been taking bisphosphonates for 9.5 years, with more than half of them taking the medication to prevent bone breaks.

Researchers also found that the risk for fractures among people taking bisphosphonates was higher whether people had osteopenia, or early bone loss, or full - blown osteoporosis, which Yeh said could suggest that either the drugs themselves are harmful or that the people taking them had other risk factors.

Paschou's team found no evidence of any detrimental effects of osteoporosis medications on glucose metabolism, but a possible beneficial effect with the use of bisphosphonates — medications used to help prevent the loss of bone mass and treat osteoporosis.

A pharmacologist by training, I also knew that the bisphosphonates — a class of drugs developed for osteoporosis sufferers — were then being tested on OI patients.

The researchers designed a molecule combining 7,8 - dihydroxyflavone, which mimics a protein critical for development and function of the nervous system, and bisphosphonate, a type of drug that sticks to bones.

The team is now working on showing exactly what changes the bisphosphonates cause in the macrophages, something which could help us understand exactly how cancer is able to evade the immune system.