In combination with a separate technique that measures the degree to which a gene is expressed, the researchers then identified genes that were either mutated or functionally altered through expression levels in
these bladder cancer cell lines.
A University of Colorado Cancer Center study published in the journal Oncogene used next - generation sequencing technologies to perform the most detailed DNA - based analysis to date of 25 commonly used
bladder cancer cell lines, allowing researchers to match patient tumors with their closest genetic cell line match, and demonstrated genetic alterations that may make cells more or less sensitive to common therapies.
The study describes the mutational landscape of
bladder cancer cell lines.
Not exact matches
The study used whole - exome sequencing to characterize genetic alterations that occur at the single nucleotide level for all genes in 25
cell lines commonly used as models of
bladder cancer.
It demonstrates that alterations in these
cells lines do indeed match changes in samples of human
bladder cancer.
Like these
cell lines, not all human
bladder cancers share the same genetic changes.
«Whole - exome sequencing predicts which
bladder cancers,
cell lines respond to cisplatin.»
Red foods like red bell peppers and tomatoes contain a phytochemical called lycopene, which may have an anti-inflammatory affect on the
cells lining the heart and blood vessels, and may reduce the risk of developing prostate
cancer among other
cancers such as breast, lung,
bladder, ovarian, and colon.
Bladder cancer in dogs and cats is a tumor of the
cells lining the organ that collects urine excreted by the kidneys.
Transitional
cells line the
bladder area and it is in these
cells that
bladder cancer is most likely to develop and then spread to muscle, fat, and tissue.