Sentences with word «blastema»

To me it's surprising but also revealing, as it tells us that if we want to manipulate or enhance blastema formation in a non-regenerative system we now have the key ingredients that have been favored during evolution as being critically important.

Primordia may synthetize a molecule that remains unknown and may promote or maintain blastema growth, the new tissue which is being regenerated.

Drs Benjamin L King and Voot P Yin at the MDI Biological Laboratory in Bar Harbor carried out a next - generation sequencing analysis into the genetics of these organisms to identify the genetics regulating blastema formation — the key step in regeneration in animals such as the zebrafish, axolotl and the bichir, where the injury site forms a mass of dedifferentiated cells that proliferate and differentiate in a coordinated manner to re-form the lost appendage.

Knowing that blastema formation is a key part of limb regeneration in animals with this capability as adults, researchers Benjamin L King and Voot P Yin looked at three regenerative species — the zebrafish, axolotl and the bichir — with the aim of finding out what genes control this event.

Instead of an organized basement membrane, there was a blastema — a circular arrangement of highly proliferative, undifferentiated cells that grew until the tissue was replaced — without scarring.

The formation of a blastema is the critical first step in the regeneration process.

In particular, the scientists studied the formation of a mass of cells called a blastema that serves as a reservoir for regenerating tissues.

Most regeneration research focuses on the stub — or blastema — that forms over the wound of a severed limb.

Importantly, cellular and molecular analysis by Seifert's group has now demonstrated that spiny mice regenerate ear tissue by forming a blastema.

Methodical demonstration of a blastema was important to place spiny mice in the context of regeneration in other vertebrates.

Many regeneration biologists believe that inducing a blastema in humans would be a major step towards stimulating tissue regeneration.

Daley notes that when amphibians regenerate their limbs, they form a cluster of primitive undifferentiated cells called a blastema.

«Given the remarkable regenerative capacity of limb tissues in all three model systems, we expected to identify some overlap in the molecular pathways during formation of the blastema, the critical first step in the regeneration process.

Most of the scientific focus to date has been on trained on the blastema, a remarkable cluster of cells that forms at the base of an amputated limb or damaged tissue and is the modus operandi for regeneration.

«The goal of this study was to determine whether these animals used the same genetic circuit to create and maintain the blastema tissue after injury.

«Can we find similarities in the gene expression occurring in this early stage and in the cell types developed in the blastema?»

Each appendage has different tissue composition and rates of regeneration, yet when you look at the critical structure, the blastema, there's actually a well - conserved set of miRNAs.

At a cellular level, we knew that all three animals form a specialized tissue after wound healing, called the blastema.

The researchers, whose work is published in the journal Public Library of Science One, studied the formation of a mass of cells called a blastema in each of the three species.

A blastema is a critical first step in the regeneration process and the scientists these in each creature had a common set of genes.