Sentences with phrase «bleeding disorders in»

Researchers will develop an assay to measure canine thrombopoietin (TPO), a bone marrow growth factor, to improve the diagnosis and treatment of bleeding disorders in dogs with immune platelet defects.

Approach to the diagnosis of bleeding disorders in the dog and cat.

When left untreated, it leads to a variety of different bleeding disorders in dogs.

Von Willebrand's disease (vWD) is the most common inherited bleeding disorder in dogs.

Von Willebrand's disease (vWD) was first recognized in humans, but is now known to be the most common inherited bleeding disorder in dogs.

In 1924, a Finnish doctor by the name of Erik Adolf von Willebrand documented and studied a rare bleeding disorder in an isolated group of people; he showed that the disease was heritable as opposed to infectious in nature.

Not exact matches

In early September, Alnylam stopped giving doses of its fitusiran drug for a rare bleeding disorder to patients enrolled in clinical studies after the death of a patienIn early September, Alnylam stopped giving doses of its fitusiran drug for a rare bleeding disorder to patients enrolled in clinical studies after the death of a patienin clinical studies after the death of a patient.

Caution is advised in people with bleeding disorders or in those taking drugs that may increase the risk of bleeding.

Potential subjects were accepted into the study if they had none of the following conditions: severe or symptomatic cardiac disease or hypertension; history of bleeding disorders; chronic history of gastric, intestinal, liver, pancreatic, or renal disease; any portion of the stomach or the intestine removed (other than an appendectomy); history of intestinal obstruction, malabsorption, or use of antacid drugs; cancer (active or use of medications for a history of cancer treatment within the past 5 y); history of chronic alcoholism; a convulsive disorder; or abnormal results in screening blood or urine samples.

Much of her clinical management in the perinatal period has focused on the following: 1) women with a history of childhood sexual abuse and its effects on childbearing; 2) methods to alleviate clinical symptoms of pregnancy such as premature labor, hyperemesis gravidarum, bleeding; and the psychological issues of anxiety and depression; 3) attachment disorders; 4) helping women through events of traumatic birth and loss; 5) postpartum mood disorders; and 6) methods of pain relief in labor with self - hypnosis.

In most cases, abruption is caused by placental disorders or arterial bleeding that can tear the placenta from the uterine wall.

«For a patient with insufficient platelets due to bleeding or an inherited disorder, physicians often have to resort to platelet transfusions, which can be difficult to obtain,» said Dr. Wilbur Lam, another of the paper's co-authors and a physician in the Aflac Cancer and Blood Disorders Center at Children's Healthcare of Atlanta and the Department of Pediatrics at the Emory University School of Medicine.

«If you can prevent antibody formation in the first place, by finding some way of producing immunological tolerance that gets around that type of protocol, that would be a major advantage,» says David Lillicrap, a clinician and researcher who specializes in bleeding disorders at Queen's University in Kingston, Ontario, Canada.

Shire CEO Flemming Ornskov - who has a large conventional haemophilia business and is also chasing Biomarin and Spark in hunting a cure for the bleeding disorder - sees both the opportunities and the difficulties of gene therapy.

Researchers are reporting the highest and most sustained levels to date of an essential blood - clotting factor IX in patients with the inherited bleeding disorder hemophilia B.

Thanks to a breakthrough led by researchers in the Cockrell School of Engineering at The University of Texas at Austin, treatment for hemophilia can now be administered via a biodegradable system, a capsule, giving people affected by the hereditary bleeding disorder hope for a less expensive, less painful treatment option than conventional injections or infusions.

A rare inherited disorder that has been identified in about 400 people worldwide, HPS is mainly characterized by decreased pigmentation (ocular or cutaneous albinism) and a lack of platelet dense bodies that causes bleeding problems.

• Patients must have adequate coagulation (international normalized ratio (INR) or prothrombin time (PT), partial thromboplastin time (PTT) ≤ 1.5 times ULN) • Adequate liver function (total bilirubin ≤ 1.5 times the ULN, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 2.5 times ULN Exclusion Criteria: • Presence of active / uncontrolled central nervous system involvement • History of clinically significant cardiac disease; uncontrolled hypertension • Left ventricular ejection fraction (LVEF) < 45 % • Allogeneic stem cell transplant within 100 days before first dose of study drug • Known history of human immunodeficiency virus (HIV) infection • Chronic or active hepatitis B or C, requiring antiviral therapy • Evidence of history of bleeding disorder, dialysis, or coexisting cancer that is distinct in primary site or histology from the cancer evaluated in this study • Serious, uncontrolled infection • Unresolved chronic toxicity > grade 1 from prior therapy • Use of strong CYP3A4 inhibitors or strong inducers within 7 days prior to the start of study treatment and for the duration of the study

To better define the phenotype associated with pathogenic RASGRP2 variants, we compared high - throughput sequencing and phenotype data from 2,042 cases in pedigrees with unexplained bleeding or platelet disorders to data from 5,422 controls.

Reportedly, it has been used in the treatment of a number of health conditions which include brittle bone, hair, teeth and nails, white spots on nails, gingivitis, tonsillitis, inflammation of the mucous membranes of the mouth, rheumatic disorders, edema, osteoarthritis, diabetes, acne, wounds, itchiness, rashes, burns, frostbite, chilblains, athlete's foot, cracked and tired feet, drawing out pus from boils and carbuncles, ulcers, fistulas, herpes simplex, dyspepsia (impaired digestion), gastrointestinal conditions, cardiovascular diseases, respiratory tract infections, bronchitis, fever, malaria, bladder problems, urinary tract infection, bed wetting in children, kidney stones (nephrolithiasis), prostate problems, hemorrhoids, muscle cramps, tumors, broken bones, fractures, sprains, nose bleed and other heavy bleeding.

As expected, Western diets are very deficient in vitamin K2 and although we typically get enough vitamin k to prevent bleeding disorders we don't get enough K2 to optimally run these important proteins that regulate calcium deposition.

A bleeding disorder known as von Willebrand disease — known as a coagulopathy, this condition is associated with problems in how the blood clots.

People with bleeding disorders or taking anticoagulant medication, as well as those about to undergo surgery, should avoid consuming this herb in medicinal doses.

According to Natural Medicines Comprehensive Database, whey may case low blood glucose levels (hypoglycemia) in individuals with diabetes mellitus and increase the risk of bleeding in individuals with bleeding disorders [58].

It also has blood thinning effects, and may increase the risk of abnormal bleeding in people with a bleeding disorder or taking anticoagulant medications.29 Frankincense essential oil is also not recommended for pregnant women and nursing moms, as it acts as an emenagogue and may induce menstruation, which may be dangerous for an unborn fetus.30

Most often it leads to bleeding disorders where the blood will not clot, resulting in hemorrhaging and death.

The wide range of transfusion needs might include: combating illness or disease, treating an acute blood volume loss and preventative measures in routine surgeries for dogs with bleeding disorders.

Platelets are involved in clotting the blood and may decrease (thrombocytopenia) with some illnesses, including tick borne diseases and bleeding disorders.

Dr. Jean Dodds has done much research in thyroid diseases, including a potential connection with the bleeding disorder von Willebrand's Disease and the influence of multivalent vaccinations on the incidence of thyroid problems.

Epilepsy, joint problems, bleeding disorders, heart disease, eye diseases and endocrine system disorders are just some of the known problems in this breed.

FVIII deficiency, or Hemophilia A as it is more commonly known, is a clotting disorder which leads to excessive bleeding in affected animals.

von Willebrand's disease has been identified in a wide range of canine breeds, and is the most common of the inherited bleeding disorders.

Tests that are available now are x-rays to detect displaced or malformed hips, elbows, and knees; eye tests for progressive retinal atrophy; a biopsy for sebaceous adenitis; a blood test for hypothyrodism and vonWillebrand's disease (a bleeding disorder); the BAER (1) test for deafness; and a smattering of other tests that aid in detecting breed - specific diseases.

Black tarry faeces indicates the presence of digested blood in the faeces (due to oxidation of iron) which would have originated in the upper gastrointestinal tract, the cause of this may be due to ulcers, infections, tumours, poisons, foreign bodies, platelet disorder, liver or kidney disease, respiratory tract bleeding (being swallowed and passed) or nutrition.

Responsible breeders check for health conditions such as hip dysplasia, elbow dysplasia, glaucoma, hypothyroidism, bleeding disorders, and luxating patella, a dislocated kneecap once called a «trick knee» in humans.

In serious cases this can cause a bleeding disorder called disseminated intravascular coagulation (DIC).

Infectious canine hepatitis can be spread through feces, saliva, urine, blood and nasal discharge and it results in both infection of the liver and the establishment of a bleeding disorder.

Unexplained bleeding: Although bleeding disorders do occur in pets, they usually are discovered while pets are young.

The potential side effects of Ivermectin (the active ingredient in Heartgard) include liver problems, vomiting, diarrhea, loss of appetite, depression, lethargy, skin eruptions, seizures, tremors, paralysis, autoimmune disorders, thyroid problems, fever, weakness, dizziness, coughing, nose bleeds, difficulty breathing, pneumonia, irritability, sudden aggressive behavior, nerve damage, fertility problems, and sudden death.

Overall, garlic is safe for most people with some few potential problems, primarily in people with bleeding disorders.

Breeding or pregnant pets Use with caution in pets with liver disease Use with extreme caution in cats as they are more susceptible to the toxic effects, especially bone marrow suppression and bleeding disorders Pets with pre-existing bone marrow suppression If your pet has had an allergic reaction to azathioprine or like products Directions:

Ehrlichiosis In the early stages of the disease, infected pets may have fever, swollen lymph nodes, respiratory distress, weight loss, bleeding disorders, and, occasionally, neurological disturbances.

Deficiency of this factor most commonly results in a mild bleeding disorder.

Eventually, a cascade of systemic toxicosis (elevation of toxins in the bloodstream), bleeding disorders (disseminated intravascular coagulopathy), and organ failure may occur if the disease is not managed.

Corneal degeneration (which may be identified as corneal dystrophy, which can be inherited) is a disease of the eyes; von Willebrand's Disease, a bleeding disorder, and testicular atrophy are among the secondary diseases you may see in association with hypothyroidism.

Pets with bleeding problems or kidney disease Pets with stomach ulcers or bowel disorders Use with caution in pets with liver disease Cats should not receive this drug longer than 5 days Breeding and pregnant animals Directions:

Use with extreme caution in pets with anemia, clotting disorders, bleeding, low white cell and platelet counts, kidney, liver or immune system diseases Use with extreme caution in pregnant or nursing pets.

Dr. Hackner's primary area of interest is hematology, where she is renowned in the fields of thromboembolism and bleeding disorders.

In some cases careful evaluation of the type of bleeding disorder present is necessary to raise the suspicion of hemangiosarcoma.

Founded in 1966 to help quantify the incidence of hip dysplasia and help breeders reduce its manifestation, the Orthopedic Foundation for Animals (5) reads radiographs (x-rays) and catalogs information about hip and elbow dysplasia (joint malformations), thyroid disease, congenital cardiac disease, and patellar luxation (loose kneecaps), and offers DNA testing for several diseases, including copper toxicosis, progressive retinal atrophy (an eye disease), Von Willebrand disease (a bleeding disorder) and renal dysplasia (a kidney abnormality).