Sentences with word «bleomycin»

Treatment with plerixafor prevents pulmonary fibrosis in bleomycin - induced murine pulmonary fibrosis.

Response of clonospheres was observed only at 40 and 80µM concentration of bleomycin sulphate.

d) Graph showing higher frequency of γH2Ax foci / nuclei at 40 and 80 μM dose of Bleomycin post silencing in siTRF2 silenced cells compared to Scrambled transfected HCT - 116 cells (p < 0.05).

Bristol - Myers Squibb is providing the anticancer drug bleomycin for the tests.

If they waited several days after bleomycin to trigger CHI3L1, the mice fared very poorly and scarring and mortality went up.

Inhibitory effect of CXC chemokine receptor 4 antagonist AMD3100 on bleomycin induced murine pulmonary fibrosis.

In mice given bleomycin, the researchers found that the levels of CHI3L1 declined at first and then surged.

Scientists can induce an IPF - like response in mice using a drug called bleomycin.

Using these mice, the researchers found that if they triggered CHI3L1 production early after administering bleomycin, the mice fared well, experiencing less injury, less damage and less scarring than controls.

To confirm this observation, on treatment of siTRF2 HCT116 cells with increasing Bleomycin concentrations (0μM, 40 μM and 80 μM), we observed a significantly reduced expression of CD44 and β - catenin genes compared to that of scrambled transfected HCT116 cells (Fig. 4a - c).

Furthermore, on treatment with 80μM bleomycin, a significant (p < 0.05) increase in expression of stemness genes like CD44, Oct 4 and a significant downregulation of CD24 gene (p < 0.05) was observed in clonospheric HCT116 when compared to Parental HCT116 (Fig. 3a and 3b).

Knockout of endothelin type B receptor signaling attenuates bleomycin - induced skin sclerosis in mice.

Bleomycin treated cells were harvested by trypsinization, washed twice and stained with Hoechst 33342 dye (final concentration 5μg / ml) and incubated at 37 °C for 90 minutes.

c) Graph showing dose dependant (20, 40, 60, 80 µM) increase in CD44 enriched cells post treatment with Bleomycin sulphate (p < 0.001).

In his book It «sNot About the Bike, Armstrong recalls how, on that grim morning, the oncologistoutlined a treatment protocol involving the drug bleomycin, which would sodamage his lungs that he would not be able to race again.

e) Representative Immunocytochemistry (ICC) images of γH2Ax foci showing dose - dependent increase in DSB foci post treatment with Bleomycin treatment.

d) Immunocytochemistry analysis showing reduced CD44 expression in siTRF2 silenced HCT116 post treatment with Bleomycin sulphate when compared to scrambled transfected HCT116 post treatment with Bleomycin.

Mean γH2Ax foci / nuclei was observed to significantly increase (p < 0.05) with increasing concentrations of Bleomycin (20, 40, 60, 80 μM) in parental HCT - 116 (Fig 1e and 1f).

Following which TRF2 silenced cells were treated with Bleomycin and γH2Ax assay was performed.

HCT - 116 cells grown on coverslips were treated with Bleomycin (20 - 80µM) for 4 hrs followed by 2 hrs of recovery.

To check for the presence of this subpopulation of SP cells, we exposed HCT116 to increasing concentrations of Bleomycin and performed Hoechst efflux assay.

Low number of γH2Ax foci formed / clonospheric nuclei post exposure to high concentrations (80μM) of bleomycin is indicative of rapid repair of DSBs.

The approval was based on a clinical trial comparing brentuximab vedotin plus conmbination chemotherapy (Adriamycin [doxorubicin], vinblastine and dacarbazine, or AVD) vs a chemotherapy - only regimen commonly used to treat cHL (AVD plus bleomycin, also known as ABVD).