«We can now hope to
block cellular responses to TNF,» Ma remarks, «in addition to trying to block TNF itself.»
Not exact matches
«Our experiments suggest that mGluR5 amplifies the
cellular response to a chemical signal, and that by
blocking mGlur5 receptors in inhibitory neurons involved in depression, these new therapies can achieve an antidepressant effect,» says senior author Paul Greengard, Vincent Astor Professor and head of the Laboratory of Molecular and
Cellular Neuroscience.
Moreover a small molecule which specifically
blocks the
cellular immune
response triggered by FnEDA was able to prevent skin fibrosis in mice.
Previously, Walter's team discovered that ISRIB (short for «integrated stress
response inhibitor»)
blocks this aspect of the
cellular stress
response by enhancing the activity of a protein called eIF2B, which helps keep a key protein production line operating in stressed cells.