Sentences with phrase «block epigenetic mechanisms»

Not exact matches

A breast cancer therapy that blocks estrogen synthesis to activate cancer - killing genes sometimes loses its effectiveness because the cancer takes over epigenetic mechanisms, including permanent DNA modifications in the patient's tumor, once again allowing tumor growth, according to an international team headed by the University of Pittsburgh Cancer Institute (UPCI).

Finally, a profound understanding of the molecular mechanisms underlying reprogramming, and knowledge of the epigenetic barriers that interfere or block lineage conversion, will allow for developing even better reprogramming strategies; and, thus, also feed the aim of obtaining authentic neurons.