Their surprising discovery demonstrates that the vitamin A derivative ATRA (all - trans retinoic acid), a treatment for APL that is considered to be the first example of modern targeted cancer therapy, can
block multiple cancer - driving pathways and, at the same time, eliminate cancer stem cells by degrading the Pin1 enzyme.
Not exact matches
They also determined that
blocking the enzyme reduces
multiple myeloma regeneration in experimental models derived from patient
cancer cells.
The nanoparticles carry a drug compound that
blocks a protein called Myc that is active in many types of
cancer, including
multiple myeloma.
Targeting stromal cells as well as the
cancer cells
blocks multiple cell signalling pathways that are used by
cancer cells to become aggressive.
«
Block autophagy in
multiple cancers: Trials show promise.»
D Source: Sunlight, fish - liver oils, egg yolks Effects of deficiency: Rickets in children; increased risk of colon
cancer,
multiple sclerosis, and prostate
cancer Who's at risk: Dark - skinned people living in northern climates; anyone sun deprived Fortification options: Milk Percent of vitamin D production
blocked by an SPF - 8 sunscreen: 95
Inhibiting microRNA 135b could be an exciting way to attack
cancers without resistance occurring by
blocking the effects of
multiple cancer - causing mutations simultaneously.
Bradner and Mitsiades had reported in Cell in 2011 that the inhibitor
blocks the Myc
cancer gene and thereby slows the growth of
multiple myeloma tumors in mice.
Niclosamide, an old antihelminthic agent, demonstrates antitumor activity by
blocking multiple signaling pathways of
cancer stem cells.
«Nutrient scavenging by autophagy is a process that tumors hijack to meet their energetic requirements and to provide the necessary cellular building
blocks for growth in a stressed tumor micro-environment» said White, «Preclinical models have demonstrated a critical role for autophagy in
multiple cancer types.»
The researchers are reporting preclinical findings for a potential two - treatment strategy to
block multiple mechanisms of
cancer cell metabolism in pancreatic cancer at the American Association for Cancer Research Ann
cancer cell metabolism in pancreatic
cancer at the American Association for Cancer Research Ann
cancer at the American Association for
Cancer Research Ann
Cancer Research Annual...
February 10, 2015 New screening tool could speed development of ovarian
cancer drugs University of Chicago Medicine researchers have built a model system that uses
multiple cell types from patients to rapidly test compounds that could
block the early steps in ovarian
cancer metastasis.
University of Chicago Medicine researchers have built a model system that uses
multiple cell types from patients to rapidly test compounds that could
block the early steps in ovarian
cancer metastasis.
Glossing over or omitting from the main body of the report gynecological problems such as higher rates of cervical
cancer, polycystic ovarian syndrome,
blocked fallopian tubes, pelvic inflammatory disease, hormonal disorders and
multiple births