In cell lines, the researchers first tested ruxolitinib, a general JAK inhibitor, but it did not
block tumor formation in the JAK2 - amplified cells.
But most importantly, the researchers say, in three laboratory tests of tumor growth, the drug strongly
blocked tumor formation in distant metastases and their precursors.
Not exact matches
The discovery of a treatment capable of
blocking the mechanism responsible for the
formation of metastasis and the existence of a family of promising compounds, is encouragement for their future assessment in a clinical study that aims to validate a preventive treatment against
tumor metastasis.
Liang Xu, Ph.D. member of the KU Cancer Center's Drug Discovery, Delivery and Experimental Therapeutics program and associate professor of molecular biosciences at KU, has discovered that targeting a cell - surface receptor called «CD44s» can
block pancreatic
tumor formation and recurrence after radiotherapy.
Knocking down the expression of either the fruit fly version of the FOXD1 gene or the fruit fly version of ALDH1A3
blocks the
formation of brain
tumors in a brain cancer model of the fruit fly species Drosophila melanogaster, the researchers found.
Using a mathematical modeling approach, scientists have found that certain parameters of
tumor growth in mice can predict the effectiveness of drugs that
block formation of
tumor - nourishing blood vessels.
Meds are more targeted Avastin, for instance, is a so - called angiogenesis inhibitor, which
blocks the
formation of blood vessels that feed
tumors.
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Not only can phytates
block the
formation of new blood vessels that may be feeding
tumors, they can disrupt pre-formed capillary tubes, indicating that phytates may not only help blockade
tumors, but actively cut off existing supply lines.
And many phytonutrients may help
block the
formation of new blood vessels that feed
tumors, and others appear to defend against toxic invaders.
Some studies have shown that feeding your rat certain vegetables (broccoli, cauliflower, Brussels sprouts, and others) may actively
block formation of cancerous
tumors.