Sentences with phrase «blockades with»

Researchers at The University of Texas MD Anderson Cancer Center developed a novel chimeric mouse model to test the combination therapy using immune checkpoint blockades with therapies targeting myeloid - derived suppressor cells (MDSCs).

This is the first study in humans to associate opioid blockade with improved survival.

Wherry, together with his colleagues in the Parker Institute for Cancer Immunotherapy at Penn, are involved in multiple checkpoint - related trials, in melanoma, lung cancer, renal cell carcinoma, and others, including combining checkpoint blockade with radiation.

Dual HER2 blockade with lapatinib and trastuzumab plus AI therapy was more effective than trastuzumab plus AI alone in HER2 +, HR + metastatic breast cancer.

Immunologic checkpoint blockade with anti — cytotoxic T - lymphocyte — associated antigen 4 (CTLA - 4) or anti — programmed death 1 (PD - 1) / programmed death ligand 1 (PD - L1) agents seems to have some degree of clinical efficacy in advanced mucosal melanoma, although data are limited to smaller retrospective series or subset analyses of prospective trials.

Combination OX40 agonism / CTLA -4 blockade with HER2 vaccination reverses T - cell anergy and promotes survival in tumor - bearing mice.

By combining checkpoint blockade with an anti-CD27 antibody, we have been able to show that the two approaches can be harnessed to potentially improve current treatment options.»

Low - dose chemotherapy, radiation, or targeted therapies given in combination with immune checkpoint blockade may prove to be an effective and efficient way to immunize the body against tumor cells,» says CRI Scientific Advisory Council associate director James P. Allison, Ph.D., who identified the first immune checkpoint blockade with his discovery in 1995 that the cytotoxic T lymphocyte antigen - 4 (CTLA - 4) receptor inhibited T cell responses.

«We hope this could be developed into a clinical trial testing a combination of PD - L1 and PD - 1 blockade with epigenetic therapy.

And that's a path the system can be expected to blockade with all the entrepreneurial zest it can muster.

Cara the state trooper swings into action and sets up a rolling blockade with blues lit while various people with walkie - talkies manage the traffic with the sort of airwave chat that only Americans do.

The entrance to the project space in Kunstquatier Bethanien, which currently hosts alpha nova & galerie futura's 30 - year anniversary exhibition, was blockaded with black balloons.

Not exact matches

With the Vichy French fleet destroyed at Mers - el - Kébir, and the German Navy's surface ships blockaded like they were in WWI, Italy had to go it alone.

Sources say it was those five pages, and not the deal itself, that proved pivotal Friday as last - ditch talks in the European Commission collapsed, with the holdout Belgian region of Wallonia refusing to end its blockade of the long - sought deal.

Saudi Arabia, the United Arab Emirates, Bahrain and Egypt imposed a blockade on their neighbor, closing their land, sea and air borders with Qatar.

He also has grown increasingly frustrated with Secretary of State Rex Tillerson, who has clashed with the president on issues including Afghanistan troop levels, the blockade on Qatar and Cuba policy.

When faced with countless illegal blockades by protestors and legal challenges from the British Columbia NDP coalition government, Kinder Morgan has suspended the Trans Mountain pipeline expansion spending on all non-essential activities and related spending related to the project.

With Soviet missiles in Cuba and a U.S. Naval blockade of the island in place, the Vatican secretly reached out to both sides in 1962.

It has a bad history, and the picture of God's relationship with the world, which it conjures up in many minds, is one of the chief blockades to intelligent faith in God.

None of what Lincoln achieved — the eventual abolition of slavery, the preservation of the Union — would have happened had Lincoln not thought himself constitutionally authorizedto resist the Supreme Court's decision in Dred Scott; constitutionally obligated, by his oath, to resist secession; and constitutionally empowered, as commander in chief, to fight the enemy with the full powers at his disposal, which included military force, blockade, suspension of habeas corpus, arrest and detention, seizure of enemy property, and emancipation of Southern slaves.

Farmers For Action (FFA) demonstrated and created blockades at Arla Foods UK and Muller Wiseman Dairies processing facilities last week, in its latest attempt to bring an end to its long - running dispute with processors over farm gate milk prices.

Pink also plans on working with state police to put up fencing and additional blockades along Riverview Road.

D. B. Scott and M. E. Tunstall, «Serious Complications Associated with Epidural / Spinal Blockade in Obstetrics: A Two - Year Prospective Study,» Int J Obstet Anesth 4, no. 3 (1995): 133 — 139.

1) Crimea is a peninsula, so it can receive sea shipments, and 2) Isn't it right next to Russia (See James K's question) Unless you meant blockade, but even then, isn't Crimea nearly contiguous with Russia?

With the rising Ukrainian nationalism and the increasingly more and more visible loss of control of the central government over the country (in the recent trade blockade of Donbass by Ukrainian nationalists, president Poroshenko protested the blockade but was unable to force its lifting), it is possible that Ukrainian military will take more forceful action against Donbass and Luhansk, which may force Russia's hand, so not all risk of war is beyond us.

A spokeswoman for George Galloway explains how the Bethnal Green and Bow MP was deported from Egypt after attempting to take 200 aid trucks into the blockaded Gaza Strip with other activists.

In June, Saudi Arabia together with Bahrain, the UAE and Egypt imposed an extensive blockade on Qatar, blaming the country for providing support for terrorism and hence, being responsible for destabilising the region.

Obviously, countries with large navies are going to want to have blockades, and countries with small navies are not going to want them, so the Melian dialogue seems to apply in this case.

This week Sisters Uncut blockaded the Treasury building with fences to visually communicate our demand for the government to ring - fence funding for domestic violence services.

Indeed, it was McDonnell's comments on the embargo that were picked up by sections of the British media today, with the shadow chancellor promising that if Labour came to power it would «break the blockade».

«I will keep going because I think these are good reforms,» he told reporters on the sidelines of the G7 summit in Japan, adding that his government would ensure «freedom of movement» for citizens beset with rail strikes and fuel blockades.

The questions raised include when to enact the emergency blockades at each of the entrances and a plan to deal with cars when they are forced exit the closed Thruway.

On the value of these delegations in giving a first - class intensive examination of the issues impacting on the peace process and Palestinians living under occupation and blockade, Caabu Director Chris Doyle writes: «The overwhelming majority of delegates return energised by what they have seen and with a sense of duty to address the injustices they have witnessed.

Department for Business blockaded over its continued military contracts with Israel, as UK abstains from UN war crimes vote

Syrian trade would have to be blocked by shutting down its land borders with Turkey and Iraq, while a naval blockade and «rigorous searches» of vessels bound for Lebanon could prevent the regime receiving shipments of arms from Russia and Iran.

«I support gradually escalating sanctions, including boycotts and divestment, until Israel stops expanding the settlements on the West Bank, ends the blockade of Gaza, and starts honestly negotiating a settlement in accord with international law, a two - state solution based on the pre-1967 borders.

Hawkins, along with 12 other people, blockaded the entrance the facility on Tuesday morning, according to social media posts from activist group We Are Seneca Lake.

With a new piece of legislation, Westchester lawmakers will look to piggyback on a recently passed New York City law blockading the spread of a synthetic marijuana known commonly as «spice.»

A type of immune therapy known as PD - 1 blockade controlled cancer in 77 percent of patients with defects in DNA mismatch repair — the system cells use to spell - check and fix errors in DNA (SN Online: 10/7/15).

In a retrospective analysis of clinical trial data, they found that melanoma patients with highly aneuploid tumors were less likely to benefit from immune checkpoint blockade therapy than patients whose tumors showed fewer chromosomal disruptions.

In contrast, PD - L1 blockade increased the capacity of Treg cells to multiply (and hence their overall numbers), but only in cells from patients with viremia, i.e. those that had detectable virus in their blood.

So with checkpoint blockade T cells will recognize new peptides that shouldn't be there.

But when this balance is thrown off, such as when the body is chock - full of the protein, or when the blood - brain barrier — the blockade that keeps potential dangers out of the brain — deteriorates with age, the brain may get an extra dose, Song proposes.

All the greenhouse gases absorb infrared, and they also release the infrared, so these act as blockades to the infrared, leaving the atmosphere and going off into space; and the Earth warms up to send off even more infrared from the surface in order to reach its state, sort of a steady state with regard to space.

Suppression of tumor growth by terbinafine is associated with decreased cholesteryl ester concentrations, restoration of PTEN expression, and inhibition of AKT - mTOR, consistent with blockade of SQLE function.

«These studies provide promising evidence that autophagy blockade can be achieved, and that combining autophagy inhibitors with other cancer therapies in very sick patients can be accomplished safely in most cases.

«Perhaps we can also combine resident memory T cells with other therapies such as checkpoint modulators (PD1 blockade) that would ensure a more hospitable environment for the reinfused cells.»

One phase I trial of an immune checkpoint blockade drug combined with two established targeted therapies yielded 40 - 50 percent response rates among patients with metastatic kidney cancer.

Their study of fecal samples from 105 patients treated with immune checkpoint blockade indicates that certain characteristics of patients» microbiomes correlate with slower disease progression while other qualities are associated with rapid worsening of the disease.

«Is there an existing T cell response that is of high quality that we should build upon — with checkpoint blockade, for example?