Sentences with phrase «blocked cell cycle progression»
Inhibition of mTOR expression or function blocked cell cycle progression from G1 to S phase associated with modulation of the CDK inhibitors p21waf1 and p27kip1.
http://cancerres.aacrjournals.org/ Not exact matches
This contradictory behavior explained that Cyclin D1 acts as a negative regulative protein under some conditions rather than a positive regulator in the cell cycle, i.e. the modest increase in Cyclin D1 expression could hasten the G1 phase while the overexpression may lead to block the progression through the S - phase [28, 29].
While during S phase the cell automatically suppresses Cyclin D1 formation because it has the ability to inhibit DNA synthesis which may block the cycle progression and lead to the cell - arrest in this position [9].