Sentences with phrase «blocked tumor growth»

In some of the children, the drugs blocked tumor growth; in others, they reduced tumor size.

But so far in trials for ovarian cancer they have blocked tumor growth in many patients, Levine notes.

Excitingly, we have shown in mouse models that disrupting Yap1 blocks tumor growth,» he says.

Not exact matches

Cancer: Flaxseed may protect against breast cancer, prostate cancer, and colon cancer by inhibiting tumor growth and blocking enzymes that are involved in the spread of tumor cells.

An experimental drug in early development for aggressive brain tumors can cross the blood - brain tumor barrier, kill tumor cells and block the growth of tumor blood vessels, according to a study led by researchers at the Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James).

Researchers found that a combination of drugs — one targeting epidermal growth factor receptor (EGFR) and one targeting tumor necrosis factor (TNF)-- effectively blocks the cancer from using TNF as an escape route.

A study published in the journal PLOS ONE reports that the synthetic molecule JK - 31 blocks the signalling of a «growth factor» chemical that promotes the creation of networks of blood vessels to feed tumors.

Patients received a tandem of lenalidomide, a drug that kills tumor cells, blocks blood vessel growth, and acts on the immune system, and dexamethasone, an anti-inflammatory agent, plus one of three new agents:

By contrast, when the team treated the mice with radiation plus a CCL2 - blocking antibody, the tumors» recruitment of monocytes and macrophages was sharply reduced, and the tumor growth was slowed more dramatically.

They already knew of one such compound, a chemical called PD09859 that is one of 60,000 agents the NCI had screened for ability to block growth of human tumor cells.

«We demonstrated that alpha - KGDH interacts with Gcn5 in the cell nucleus and found that tumor cell proliferation and tumor growth were inhibited when alpha - KGDH was blocked from entering the cell nucleus or by disruption of Gcn5's binding to succinyl - coenzyme A,» said Lu.

But most importantly, the researchers say, in three laboratory tests of tumor growth, the drug strongly blocked tumor formation in distant metastases and their precursors.

They also found that distant metastases and their precursors processed glucose through a growth - promoting series of metabolic reactions called the pentose phosphate pathway, which burns (or oxidizes) glucose - derived molecules into building blocks for tumors.

In a mouse model of melanoma, blocking this pathway resulted in reduction of tumor growth.

To demonstrate the potential for treating lung disease, the researchers used the nanoparticles to block two genes that have been implicated in lung cancer — VEGF receptor 1 and Dll4, which promote the growth of blood vessels that feed tumors.

By blocking these in lung endothelial cells, the researchers were able to slow lung tumor growth in mice and also reduce the spread of metastatic tumors.

As proof - of - principle of the potential efficacy, Zhang's team grew human ovarian tumors in immunocompromised mice, then injected short - interfering RNAs to block the tumors» growth using RNA interference against FAL1.

A breast cancer therapy that blocks estrogen synthesis to activate cancer - killing genes sometimes loses its effectiveness because the cancer takes over epigenetic mechanisms, including permanent DNA modifications in the patient's tumor, once again allowing tumor growth, according to an international team headed by the University of Pittsburgh Cancer Institute (UPCI).

Cancer treatments often target tumors by cutting off blood vessels and other nutrient supply routes, so Monje and others are interested to learn whether it may be possible to target nerves via analogous therapies or by simply blocking secreted neural growth factors.

«Blocking known cancer driver unexpectedly reveals a new tumor - promoting pathway: Targeting both pathways with drug inhibitors more effective in stopping colorectal cancer growth.»

The scientists in Augustin's laboratory consequently pursued preclinical tumor therapy experiments, which were aimed at not just blocking angiogenesis, but to also suppress the production of tumor - promoting growth factors in endothelial cells.

Several anti-cancer drugs attempt to halt the growth of tumors by blocking mTOR, a key part of a growth - regulating network that is often disrupted in cancer cells.

«Potential pancreatic cancer target challenged: New research finds PDX1 critical for cancer growth, but blocking it may lead to more aggressive tumors.»

These inhibitors effectively targeted and blocked Msi expressing cells, resulting in halted tumor growth in animal models as well as in patient - derived cancer cells, which harbor more complex mutations and are uniformly drug - resistant.

Howard Hughes Medical Institute scientists have designed a potential cancer therapy that uses a unique strategy to block mTOR, a molecule that helps drive the growth of many tumors.

When a tumor begins to develop, macrophages attempt to block its growth.

Earlier studies by Basu and others have shown that dopamine blocks the growth of new blood vessels in tumors by inhibiting the action of vascular endothelial growth factor - A (VEGF - A).

Using a mathematical modeling approach, scientists have found that certain parameters of tumor growth in mice can predict the effectiveness of drugs that block formation of tumor - nourishing blood vessels.

Now, researchers have found that blocking a key enzyme involved in anaerobic glycolysis significantly slows the growth of tumors.

The first clinical trial of a drug to block vasculogenic mimicry — and thus potentially limit tumor growth — has begun in the United States and Taiwan.

«RNAi therapies are a unique approach to cancer treatment as they have the potential to «turn off» the genes» coding for proteins involved in cancer cell division,» said Ramesh K. Ramanathan, M.D., medical director of the Virginia G. Piper Cancer Center Clinical Trials Program at Scottsdale Healthcare and deputy director of the Clinical Translational Research Division of the Translational Genomics Research Institute (TGen) in Phoenix, Ariz. «Using a lipid nanoparticle, the RNAi drug can be delivered to a cancer cell to block the expression of specific proteins involved in tumor growth.»

They succeeded in blocking this enzyme in mice with breast cancer, thus reactivating senescence and stopping tumor growth.

Bradner and Mitsiades had reported in Cell in 2011 that the inhibitor blocks the Myc cancer gene and thereby slows the growth of multiple myeloma tumors in mice.

«If this is so and we can use drugs to block IL - 34, that may help limit tumor growth.»

Yoon says the presence of these cells could be a marker for tumor growth and metastasis. Because tumors often metastasize along lymph ducts and into lymph nodes, studying this type of cells could lead to new targets for blocking tumor metastasis.

Pazopanib hydrochloride may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

Kandel and colleagues at the Pediatric Tumor Biology Laboratory were the first to describe how experimental pediatric tumor growth could be suppressed by blocking a molecule called vascular endothelial growth factor (VEGF) from performing its naturalTumor Biology Laboratory were the first to describe how experimental pediatric tumor growth could be suppressed by blocking a molecule called vascular endothelial growth factor (VEGF) from performing its naturaltumor growth could be suppressed by blocking a molecule called vascular endothelial growth factor (VEGF) from performing its natural job.

When they blocked IKK2 activity in the mice with lung cancer, the mice had smaller tumors and lived longer, suggesting that the enzyme is necessary for NF - KB to stimulate tumor growth.

«Systemically and chronically blocking IKK2 activity is too toxic to be used in chemotherapy, but we might be able to target another molecule in the signaling pathway by which IKK2 regulates tumor growth.»

«Nutrient scavenging by autophagy is a process that tumors hijack to meet their energetic requirements and to provide the necessary cellular building blocks for growth in a stressed tumor micro-environment» said White, «Preclinical models have demonstrated a critical role for autophagy in multiple cancer types.»

When we blocked the enzyme heparanase, that degrades proteoglycans, it stopped the growth of the tumor cells, says Karin Forsberg Nilsson (Uppsala University / SciLifeLab), who has led the study.

«Navire's compounds potently bind SHP2 and prevent activation of the protein, blocking its ability to promote tumor growth,» said Virani.

They showed that T cells in mice that could not make PSGL - 1 delayed tumor growth, suggesting that blocking PSGL - 1's function would help T cells fight tumors.

Scientists at MCG say a logical and effective new treatment target for certain cancers is to block production of the chemical that initiates the call that allows tumor growth.

PP2A mediates diosmin p53 activation to block HA22T cell proliferation and tumor growth in xenografted nude mice through PI3K - Akt - MDM2 signaling suppression.

Conversely, blocking CXCR4 / CXCL12 pathway in triple - negative (TN) BC does not reduce tumor growth, and can even increase metastatic spread.

Block of purinergic P2X7R inhibits tumor growth in a c6 glioma brain tumor animal model.

Furthermore, we found that human IL - 15 mediated insulin - like growth factor - 1 production in CD215 + myeloid cells and blocking IGF - 1 reduced the tumor - promoting effect of IL - 15.

Possible reduction in certain types of cancer: «It appears to work primarily by blocking the growth and metastatic spread of tumors, controlling the cell cycle, and by reducing inflammation.»

«We not only uncovered the biological pathway stimulating cancer growth, but we found a compound that blocked it, increasing the survival of mice carrying human metaplastic breast tumors,» Chang says.