Yoon says the presence of these cells could be a marker for tumor growth and metastasis. Because tumors often metastasize along lymph ducts and into lymph nodes, studying this type of cells could lead to new targets for
blocking tumor metastasis.
Not exact matches
The discovery of a treatment capable of
blocking the mechanism responsible for the formation of
metastasis and the existence of a family of promising compounds, is encouragement for their future assessment in a clinical study that aims to validate a preventive treatment against
tumor metastasis.
This blood vessel normalization results in an increased barrier function on the one hand — thereby
blocking cancer cell dissemination and
metastasis - and in enhanced
tumor perfusion on the other hand, which increases the response of the
tumor to chemotherapy.
Loss of either GSTO1 or RYR1, the researchers report, decreased the number of cancer stem cells in the primary
tumor,
blocked metastasis of cancer cells from the primary
tumor to the lungs, decreased the duration of chemotherapy required to induce remission and increased the duration of time after chemotherapy was stopped that the mice remained
tumor - free.
The research suggests that a cytokine produced by inflammatory cells near a prostate
tumor induces cancer cells to decrease production of a protein that
blocks metastasis.
So a drug that
blocks DDR2 from binding with collagen won't destroy the
tumor, but it could inhibit the invasion of these
tumors into surrounding tissue and reduce
metastasis.
May 12, 2016 Stopping cancer in its tracks Researchers from the University of Chicago have shown that inhibiting autophagy, a self - devouring process used by cells to degrade large intra-cellular cargo, effectively
blocks tumor cell migration and breast cancer
metastasis in
tumor models.
We found that allosteric inhibition of the ABL kinases effectively impaired breast cancer bone
metastasis and
blocked tumor - induced osteolysis in mouse models.
Curcumin has the ability to
block every stage of cancer development, from cell mutation, to
tumor growth, to
metastasis.