When it is experimentally prevented (either by severing the projecting axons, by treating them with the drug vinblastine, which
blocks axonal transport, or by administering 6 - hydroxydopamine, which destroys the nerve endings), the innervating sympathetic neurons in the ganglion die off.
The lethal effects of
blocking the axonal transport of NGF can be completely overcome, however, by supplying the cell bodies with externally administered NGF.
Not exact matches
Inhibiting this channel
blocked the formation of
axonal varicosities.
In the current study, Freeman and colleagues identified Axed, showed that it functions downstream of SARM to execute
axonal degeneration, and, surprisingly, that the protection afforded by
blocking Axed was even stronger than SARM.
We hypothesize that these aggregating proteins also
block the transport of normally transported
axonal proteins, and thus cause neurodegeneration and neuronal death by impairing
axonal transport.