Other, but rarer, causes of metastatic calcification include kidney disease (this is the most common cause in cats), malignant tumors producing abnormal hormones that
increase blood calcium concentrations (e.g. tumors of the lymphoid system and glands of the anal sac), diabetes mellitus and lung disease.
Finally, acute changes in
blood calcium concentrations do not seem to elicit the secretion of the phosphaturic hormone fibroblast growth factor 23 (FGF - 23), which is produced by bone - forming cells (osteoblasts / osteocytes) in response to increases in phosphorus intake (see the article on Phosphorus)(2).
The physiological functions of calcium are so vital to survival that the body will stimulate bone resorption (demineralization) to maintain
normal blood calcium concentrations when calcium intake is inadequate.
A slight drop
in blood calcium concentration (e.g., in the case of inadequate calcium intake) is sensed by the parathyroid glands, resulting in their increased secretion of parathyroid hormone (PTH).
Calcium absorption in the intestinal tract of rabbits is much higher than in other species and does not depend on vitamin D, so high - calcium diets may lead to
increased blood calcium concentrations.
Because there is a small risk that temporary interference with calcium regulation may occur, it is usually recommended that cats remain hospitalised for a few days after surgery, and
blood calcium concentrations are monitored during this time.
Calcinosis cutis develops in some animals but not others, even though they have similar steroid hormone or
blood calcium concentrations.
The parathyroid glands are responsible for maintaining this delicate balance and keeping
the blood calcium concentration within an optimal range.