Vascular endothelial dysfunction promotes vasoconstriction and favors platelet aggregation, white
blood cell adhesion, and smooth muscle cell proliferation.
Lowering these three risk factors means the consumption of dark chocolate lowered participants» risk of atherosclerosis, a condition that can be caused by arterial stiffness and white
blood cell adhesion.
Rather, restoring normal nitric oxide levels appears the most efficient, effective way to reduce red
blood cell adhesion, the researchers write.
The good news is that restoring normal levels of nitric oxide can substantially reduce red
blood cell adhesion, said Dr. Tohru Ikuta, a molecular hematologist at the Medical College of Georgia at Georgia Regents University.
The study also points to a potentially new therapeutic target, the self - adhesion molecule P - selectin, which the researchers found played a central role in increased red
blood cell adhesion.
Not exact matches
This drug (vedolizumab) blocks a specific
adhesion molecule on the surface of the T -
cell and thereby inhibits immune
cells from binding themselves to receptors present in the intestine, preventing the T -
cells from penetrating the
blood vessels in the intestinal tissue.
«Inflammatory arthritis is caused when immune
cells are recruited from the
blood into the joint in a highly regulated process controlled by chemoattractants and
adhesion receptors,» says Andrew Luster, MD, PhD, chief of the MGH Division of Rheumatology, Allergy and Immunology, director of the CIID and senior author of the report.
Their studies indicate that the two conditions common in sickle
cell disease, dramatically increase red
blood cells»
adhesion to the lining of
blood vessels walls and the debilitating pain crises that can result.
The endothelial
cells in insulin - receptor knockout mice expressed more of the VCAM - 1
adhesion molecule that helps white
blood cells grab onto the growing plaques, and
blood vessels gathered four times as many white
blood cells.
Only women who have previously suffered from placental malaria develop substantial levels of protective antibodies that prevent the
adhesion of red
blood cells to placental CSA.
We have found that tumor
cells in the circulation can mimic the physical mechanisms used by white
blood cells to traffic through the body and adhere to the
blood vessel wall, and we have explored strategies to interrupt this metastasis process by targeting specific
adhesion receptors.
The Lauffenburger research group focuses on elucidating important aspects of receptor - mediated regulation of mammalian
blood and tissue
cell behavioral functions such as proliferation,
adhesion, migration, differentiation, and death.
In addition to the niacin it supplies, brown rice may also help raise
blood levels of nitric oxide, a small molecule known to improve
blood vessel dilation and to inhibit oxidative (free radical) damage of cholesterol and the
adhesion of white
cells to the vascular wall (two important steps in the development of atherosclerotic plaques).
They guard against heart disease by making capillaries stronger and more flexible, while reducing the
adhesion, or «stickiness,» of red
blood cells, making them less likely to form atherosclerotic plaque.
They also contain phytonutrients that prevent
cell adhesion to
blood vessels and forming plaque buildup, which maintains healthy
blood pressure and improves
blood circulation.
They also prevent LDL oxidation, and inhibit SMC proliferation and
adhesion of inflammatory
blood cells to vessel walls.
One of the earliest events in the development of atherosclerosis is the recruitment of inflammatory white
blood cells from the
blood to the arterial wall by vascular
cell adhesion molecules (42).