Sentences with phrase «blood cell donors»

Until a smaller study on sex mismatches by the same Dutch team six years ago, no one had thought to look at the pregnancy history of red blood cell donors, says Rutger Middelburg, an epidemiologist with Sanquin Research in the Netherlands, who helped lead that pilot work and the study published Tuesday.

The American Red Cross and the researchers themselves were quick to say the study is not definitive enough to change the current practice of matching red blood cell donors to recipients.

Not exact matches

At present artificial red blood cells are produced from donor blood and the method isn't efficient because limited quantities of RBC can be produced.

Potential donors must also have blood drawn to test for HIV, HTLV (human T - cell lymphotropic virus), Syphilis, Hepatitis B, and Hepatitis C.

If your twins are fraternal, it is also good to know that most current cord blood treatments require the use of a well matched donor's stem cells, like a sibling's.

Healthy, non-cancerous stem cells from a donor can then repopulate the blood.

Two labs have found a way to create cells that can form new blood — paving the way for donor - free blood transfusions and bone marrow transplants

An engineered bone that has its own marrow can encourage donor stem cells to produce blood, a feat that could help people with anaemia and rare immune diseases

A potentially fatal battle between the immune cells of a blood marrow donor and a recipient seems to kill off any HIV as a side effect

They both had standard chemotherapy to kill their native blood cells before undergoing a bone - marrow transplant from a donor to repopulate their blood.

Blood cells made by the donor stem cells inside the implant were able to get into circulation where they mixed with the host's own blood cBlood cells made by the donor stem cells inside the implant were able to get into circulation where they mixed with the host's own blood cblood cells.

Nearly half of 13 blood donors also had T cells that seek and destroy cells that make S. aureus Cas9 protein.

Six months later, blood cells from both the donor and host were still circulating around the body.

They received either a saline placebo or plasma — blood from which the red cells have been removed — from blood donors aged 18 — 30.

In human donor cells and mouse experimental models, the researchers demonstrated that TSLP specifically targeted neutrophils — white blood cells that constitute the first line of defense against bacterial infections.

To prepare the virus - specific cells, «we take blood from healthy donors who have already been exposed to these viruses and who we have confirmed have immune cells that can fight the infections,» Tzannou said.

And even cells that were young, such as white blood cells that may be just a few days or weeks old, still carried the distinct genetic imprint of their 50 - year - old donor.

He did, however, publish a paper last year documenting a study in which he infused three cancer patients with white blood cells from young donors who had been injected with G - CSF.

The implications were hardly lost on the Bethesda crowd: If the virus was transmitted in cell cultures in Ruscetti's lab, it could also be contaminating the nation's blood supply as a result of blood donations from unknowingly infected donors.

Then they would transfuse donor bone marrow rich in the highly prized stem cells that are capable of generating new, normal blood.

New findings presented today indicate that with proper considerations, haploidentical (half - matched) transplants or transplants using cord blood cells can be viable, effective alternatives when a fully matched donor is not available.

«We studied human T cells, isolated from blood donors of all ages, to compare mature cytotoxic T cells with naive ones,» said Philip Ansumana Hull, graduate student in Ott's lab and one of the first authors of the study.

The stem cells used to treat Paizley, specific to the blood, came from the bone marrow of a healthy adult donor.

To assess risk, Thomas Adamkiewicz, codirector of the Hemoglobinopathy / Genomics Training Program at Morehouse School of Medicine in Atlanta, surveyed four medical centers and found that seven children with sickle - cell disease had been treated with umbilical cord blood from unrelated donors.

HSCT is effectively used today as a form of «replacement» therapy for patients with hard - to - treat blood cancers, providing healthy cells from either the patient (autologous transplantation) or from a donor (allogeneic transplantation) to better equip patients to fight the disease on their own.

When antibodies against the donor's white blood cells decrease to very low levels and the crossmatch becomes negative, the patient is ready for transplant.

Abatacept, when added to the standard drug regimen used to prevent GvHD, reduced the occurrence of acute, grade III - IV GvHD from 32 to 3 percent in pediatric and adult patients who underwent mismatched unrelated donor stem cell transplants to treat advanced cancer and other blood disorders.

In the first large study to look at how blood transfusions from previously pregnant women affect recipients» health, researchers discovered men under 50 were 1.5 times more likely to die in the three years following a transfusion if they received a red blood cell transfusion from a woman donor who had ever been pregnant.

Bone marrow cells and newborn babies» umbilical cords are being considered as sources for laboratory blood, but those are limited in quantity and useful only to the donor, while hESCs could prove to be an unlimited source of universally transfusable blood.

In addition, recipients of red blood cells from donors aged 20 - 30 were associated with a six percent increased risk of death per transfused product compared with recipients of red blood cells from donors aged 40 - 50.

The researchers also found similar associations with red blood cells from younger donors.

This is the first study to suggest that red blood cell transfusions from young donors and from female donors may be associated with poorer survival in recipients.

For example, for a recipient that received six units of red blood cells, this would translate into an associated risk of death of 36 percent for recipients of all - female donor blood compared to 27 percent for recipients of all - male donor blood one year later.

HSCs can be harvested from a suitable donor and then transplanted into a patient, where, after establishing themselves in the bone marrow, they can generate healthy blood cells.

Recipients of blood from donors aged 17 - 20 were associated with an eight percent increased risk of death per unit transfused compared with recipients of red blood cells from donors aged 40 - 50.

Concerned that the drug by itself might not keep his aggressive cancer at bay, Wartman opted for a second transplant — this time with stem cells isolated from peripheral blood from an unrelated donor.

In the current study Davis's group used this approach to determine the frequency of H - Y — specific T cells in a group of blood donors.

In similar experiments at Washington University in St Louis, John Goss and Wayne Flye injected white blood cells from the spleen of donors into the thymus of rats and mice.

More recently, physicians have learned how to harvest blood - forming stem cells from a donor's blood and transplant them into a patient, sidestepping the need for an operating room and a needle stick into the pelvis to extract bone marrow.

GVHD affects up to half of the more than 30,000 people worldwide each year who receive an immune system transplanted from a donor, as either bone marrow or peripheral blood stem cells.

In general, founder cells are easy to acquire from a donor and come in one of four types: fibroblasts, keratinocytes, peripheral and umbilical cord blood, and dental pulp cells.

In animal models — and in one postmortem brain from a child who had been treated for a different disorder — Kurtzberg's team has found that donor cord blood can cross the blood - brain barrier that keeps the vast majority of molecules and cells out of the brain.

Using a new method, the scientists therefore isolated T cells specifically programmed to target the CMV virus from the blood of the donor and transferred small numbers of these cells to the patients.

Now, researchers have found that a very small subset of anti-viral immune cells, transplanted along with a donor's blood stem cells, could be enough to fight and even prevent the disease caused by CMV, in research conducted in mice and published Jan 16th in the Journal of Immunology.

The only blood components that contain DNA are white blood cells, but blood banks routinely irradiate donor pints with gamma rays to kill off these cells because they can trigger a rejection response in their new host.

Subsequently, the hematopoietic system has to be replaced with stem cells from the blood of a healthy donor.

Once donor blood cells mix with recipient immune cells, they blunt the immune attack by a process called negative selection, says Strober, who has spent 30 years developing the regimen.

In later stages, the trial will deliver cord blood cells from donors to children and adults with autism.

Starzl tested these patients, hoping to see something consistent; he observed donor cells in various tissues and blood.

About 10 days after the transplant, Strober injects the patient with millions of white blood cells extracted from the kidney donor.