Sentences with phrase «blood cell progenitors»

Then Hu expressed lincRNA - EPS in maturing red blood cells and grew these cells in the absence of the hormone erythropoietin, which normally prevents the blood cell progenitors from undergoing apoptosis.

Not exact matches

It's blood in a newborn baby's umbilical cord that's rich in a type of stem cell called hematopoietic progenitor cells (HPCs).

By using genetic «signatures», we were able to compare the blood progenitor cells responsible for overproducing megakaryocytes in our model, to progenitor cells in people with essential thrombocythemia.

A critical discovery in this research was finding that the novel progenitor has a receptor protein on its cell surface called KDR, or vascular endothelial growth factor receptor 2, which until now, was thought to be restricted to endothelial cells that form vessels, the progenitors for endothelial cells and the progenitors blood cells.

In the bone marrow, blood stem cells give rise to a large variety of mature blood cells via progenitor cells at various stages of maturation.

«Proper blood cell production is dependent on functioning hematopoietic stem and progenitor cells that are destroyed during conditioning procedures for transplantation or following bone marrow injury,» said the study's first author Kevin A. Goncalves, who performed this research as part of his PhD studies in cellular and molecular physiology at the Sackler School.

They also found that 1,4 - BQ was more toxic to HSCs, myeloid progenitors (which give rise to red blood cells and platelets, among others) and B cell lymphoid progenitors than it was to T cell lymphoid progenitors.

They also found that 1,4 - BQ was more toxic to progenitors that give rise to a single group of blood cells than it was to progenitors that give rise to multiple groups.

Moreover, a substantial increase in circulating endothelial progenitor cells, which repair damaged blood vessels, was noted after consuming bread made from the ancient grain Verna.

A team from Cold Spring Harbor Laboratory in Long Island, N.Y., reports that it staved off full - blown metastasis in mice by preventing mini-tumors in the lungs from recruiting stem cells called endothelial progenitors, which assemble into blood vessels to nourish the malignancy.

She then followed up with a closer look at role of the Igf2 signaling pathway in coaxing quiescent hematopoietic stem cells to start dividing and maturing into multi-lineage progenitors that ultimately give rise to specialized blood cells.

Through gene therapy, researchers engineered blood - forming stem cells (hematopoietic stem / progenitor cells, or HSPCs) to carry chimeric antigen receptor (CAR) genes to make cells that can detect and destroy HIV - infected cells.

Earlier mouse studies by Li and his collaborators had indicated that the expression of several imprinted genes changes as hematopoietic stem cells embark on their journey from quiescent reserve cells to multi-lineage progenitor cells, which form the many highly specialized cell types that circulate within the blood stream.

However, when mature blood cells are lost, for example through severe bleeding or during infections, HSCs become activated to generate new «progenitor» cells — the cells that replenish the blood supply and produce immune cells to fight disease.

Dr. Gabriel Ferguson, a postdoctoral fellow in the lab of Dr. Martinez - Agosto and first author of the study, built upon the lab's previous research that utilized the blood system of the fruit fly species Drosophila, showing that a specific set of signals must be received by progenitor cells to activate their differentiation into cells that can work to fight infection after injury.

The investigators found even larger reductions in the so - called progenitor cells circulating in the blood of a smaller number of laborers chosen for further study.

In male mice, however, diet - induced obesity made more active inflammatory white blood cells and enhanced their progenitors.

Researchers from the Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg and an international team have now identified an ingenious mechanism by which the body orchestrates the regeneration of red and white blood cells from progenitor cells.

In order to learn more about this process, Alexander Skupin and his team treated blood stem cells from mice with growth hormones and then watched closely how these progenitor cells behaved during their differentiation into white or red blood cells.

Glomeruli filter the blood to make urine, and both the glomeruli and the tubules are generated from kidney progenitor cells during fetal life.

To test this, the team took mouse hematopoetic progenitor cells — cells that give rise to white blood cells — and modified them to overexpress a protein called Id3.

To make the cells, Sundberg first created induced pluripotent stem cells from patients» blood cells or skin cells, then differentiated these into neural progenitor cells and finally Purkinje cells.

GM - CSF is thought to act by moving progenitor cells out of the bone marrow so that they can replenish the linings of blood vessels.

Stem and progenitor cell (PC) therapy that promotes neoangiogenesis [formation of blood vessels] is an emerging treatment modality in PAD,» according to background information in the article.

Ralph M. Steinman, Gerold Schuler, and colleagues find that large numbers of dendritic cells can be mobilized by specific cytokines from progenitors in the blood stream.

Patients with ExMI tended to have a decrease (18 percent) in the levels of progenitor cells in their blood, while the rest of the group saw an increase (14 percent).

Endothelial progenitor cells (EPCs) differentiate into the cells that make up the lining of blood vessels, and so play roles in vasculogenesis and angiogenesis.

A novel role for PECAM - 1 (CD31) in regulating haematopoietic progenitor cell compartmentalization between the peripheral blood and bone marrow.

Each of these progenitor cells follow a different pathway to become extremely specific blood cells.

For the other adult patients that might still benefit from a cord blood donor, either two cord blood units are combined for a single transplant, or more recently, there are some exciting new graft engineering technologies that are emerging to expand stem or progenitor cells in the laboratory before infusion or modify the cells in some way to make them more potent at the time of transplant.

«We have demonstrated that engineered blood vessels prepared with smooth muscle progenitor cells from hair follicles are capable of dilating and constricting, critical properties that make them ideal for engineering cardiovascular tissue regeneration,» said Andreadis.

In adult organisms, stem cells and progenitor cells act as a repair system for the body, replenishing specialized cells, but also maintain the normal turnover of regenerative organs, such as blood, skin, or intestinal tissues.

Because progenitor cells are more abundant and long - lived than blood stem cells, the finding, published in Nature in 2014, might help improve cord blood transplantation in the clinic.

Review of «Evaluating Interaction of Cord Blood Hematopoietic Stem Progenitor Cells with Functionally Integrated 3D microenvironments» from STEM CELLS Translational Medicine by Stuart P. AtkCells with Functionally Integrated 3D microenvironments» from STEM CELLS Translational Medicine by Stuart P. AtkCELLS Translational Medicine by Stuart P. Atkinson

Notch - mediated expansion of human cord blood progenitor cells capable of rapid myeloid reconstitution.

While human cord blood represents a potentially important source of hematopoietic stem and progenitor cells (HSPC), current two dimensional (2D) growth conditions employed to amplify cell numbers to the level required for many regenerative applications lead to a decline in the absolute percentage of the most primitive HSPCs [1].

The FDA has approved the use of stem cell - based products, including cord blood - derived hematopoietic progenitor cells (blood forming stem cells) for many diseases.

Title: The combination of valproic acid and lithium delays hematopoietic stem / progenitor cell differentiation Authors: Walasek MA, Bystrykh LV, van den Boom V, Olthof S, Ausema A, Ritsema M, Huls G, de Haan G and van Os R Date: 2012 Publication Details: Blood 2012 Mar 29; 119 (13): 3050 - 59

Title: GATA - 2 regulates granulocyte - macrophage progenitor cell function Authors: Rodrigues NP, Boyd AS, Fugazza C, May GE, Guo Y, Tipping AJ, Scadden DT, Vyas P, Enver T Date: 2008 Publication Details: Blood December 15, 2008 vol.

The researchers, however, observed that older brains formed fewer blood vessels and possessed a smaller pool of progenitor cells — the early descendants of stem cells that turn into neurons.

Scientists have successfully used gene editing to repair 20 to 40 percent of stem and progenitor cells taken from the peripheral blood of patients with sickle cell disease, according to Rice... Read more

By examining the results of genome - wide association studies (GWAS) in conjunction with experiments on mouse and human red blood cells (RBCs), researchers in the lab of Whitehead Institute Founding Member Harvey Lodish have identified the protein cyclin D3 as regulating the number of cell divisions RBC progenitors undergo, which ultimately affects the resulting size and quantity of RBCs.

Vascular endothelial growth factor (VEGF) expressed by neural progenitor cells (NPCs)(cyan) stimulates the growth of blood vessels (red) in the mouse embryonic hindbrain, and provides regulatory factors to promote the self - renewal of neural progenitors.

The ambulance - progenitor cell analogy isn't perfect; exercise, generally a good thing, increases progenitor cell levels in the blood, says co-first author and cardiology fellow Muhammad Hammadah.

Stem cells allow researchers to collect blood or skin samples from living patients and turn them into the brain cells affected by the disease — neural progenitor cells (NPCs) and neurons.

, Tata and Ruhrberg discuss cellular and molecular interactions between neural progenitor cells (NPCs) and blood vessels.

In the latest issue of Neuronal Signaling, Tata and Ruhrberg discuss cellular and molecular interactions between neural progenitor cells (NPCs) and blood vessels.

The VNO samples, composed of the sensory neuroepithelium, progenitor and non-neuronal supporting cells, underlying glandular and cavernous tissue and a blood vessel with blood [21], [22], yielded a mean of 37.1 million (± 3.6 million) short paired - end fragments per sample (Table 1).

By examining fetal mouse livers, which are rich sources of red blood cells and their progenitors, Wenqian Hu screened the various stages of red blood cell development for the presence of lncRNAs.

Scientists have successfully used gene editing to repair 20 to 40 percent of stem and progenitor cells taken from the peripheral blood of patients with sickle cell disease, according to Rice University bioengineer Gang Bao.