Sentences with phrase «blood cell sample»

First, although it was possible to characterize the relative proportion of mononuclear white blood cell types in the blood samples provided using the techniques developed by Accomando et al. (2014) and Houseman et al. (2012) to characterize cell type variation, and we found that protective parenting was associated with the relative proportion of monocytes in the mononuclear white blood cell sample, that proportion was not associated with youth reports of their health in young adulthood.

Not exact matches

Acquiring high - definition images of every cancer cell found in a blood sample, making characterization at single - cell resolution possible.

The third order (lower scale) is common for these 2 dosing and high - multiple blood - sampling days (days 1 and 8), with each cell on the time axis representing 1 h.

Many tumors release cells with distinctive antigens on their surfaces, and affinity - based techniques can pull these cells out of the blood sample relatively easily.

Vortex's system uses a microfluidic chip to generate tiny vortices that trap larger, more deformable cancer cells from a blood plasma sample.

In blood samples from these patients, the researchers found an increase in the percentage of gamma delta T cells, similar to what they observed in mice, which remained stable over years.

Users simply collect a blood sample from a patient, feed it into the device, and retrieve any purified tumor cells a few hours later.

«In effort to treat rare blinding disease, researchers turn stem cells into blood vessels: Patients around the world contribute skin samples to test potential new therapy.»

Researchers used tissue and blood samples to show that the gammopathy (a precursor to myeloma) in both mice and patients with Gaucher disease is triggered by specific lipids, and that the antibodies made by tumor cells in nearly a third of myeloma patients are directed against such lipids.

Studying such diseases is a good first step because they are cancers of immune cells themselves, and it's possible to analyze them with a mere blood sample.

A skin biopsy on the girl's larger leg found 5 % of cells in that sample had the same abnormality, even though her blood sample was clean.

These techniques include: human tissue created by reprogramming cells from people with the relevant disease (dubbed «patient in a dish»); «body on a chip» devices, where human tissue samples on a silicon chip are linked by a circulating blood substitute; many computer modelling approaches, such as virtual organs, virtual patients and virtual clinical trials; and microdosing studies, where tiny doses of drugs given to volunteers allow scientists to study their metabolism in humans, safely and with unsurpassed accuracy.

Researchers are developing many different versions of CAR - T cell therapies, but the basic premise is the same: Doctors remove a patient's T cells (immune system cells that attack invaders) from a blood sample and genetically modify them to produce artificial proteins on their surfaces.

«A personalised immunotherapy was prepared for each patient by taking a sample of their blood and extracting a particular type of immune cell called dendritic cells.

[Chinedu Nwokoro et al., «Inhaled black carbon in the lower airways of London cyclists»] Researchers at the London School of Medicine collected sputum samples from healthy non-smokers who walk or bike to see how much black carbon was in airway macrophages — a type of white blood cell that takes in foreign material.

So far Kajander and his colleagues have found the nanobacteria in cattle blood, in 80 % of samples of commercial cow serum in which mammalian cells are grown in the lab, and in the blood of nearly 6 % of more than 1000 Finnish adults tested.

However, Japanese scientists led by stem - cell pioneer Shinya Yamanaka are doing exactly that, he says, creating a bank of stem cells derived from cord - blood samples from Japanese blood banks.

In their investigation, Greaves and colleagues discovered incipient cancer cells in routine blood samples taken from the child at birth, strongly suggesting that the transmission happened in utero.

Current genome sequencing techniques involve the chemical disintegration of samples of red blood cells from infected patients to obtain parasite DNA, which are then sequenced.

They checked that the viral gene fragments in the child and mother were a close match, and double - checked that the samples of blood cells from the child were his and no one else's, by matching them genetically with the mother.

The newly invented technique utilises a high - throughput fluorescence scanning approach — if antibodies or drugs fail to prevent the invasion of the red blood cell by the malaria parasites, the sample will light up.

But with this technique, we can just take a small sample of non-muscle tissue, like skin or blood, revert the obtained cells to a pluripotent state, and eventually grow an endless amount of functioning muscle fibers to test.»

Finding out involves passing a sample of blood through a microfluidic device, in whose tiny channels cancer cells can be captured and identified.

With a miniscule blood sample, the HemeChip, a micro-electrophoretic device, examines and identifies hemoglobins, including hemoglobinopathies sickle cell anemia (HbSS), sickle trait (HbAS) and SC disease (HbSC).

New markers suggested include total mass of hemoglobin, altered expression of genes related to red blood cell metabolism, ironomics, storage lesions, and the presence of plasticizers from blood bags in athlete urine samples.

Blood analyzers currently on the market measure hemoglobin by chemically rupturing the red blood cells in a saBlood analyzers currently on the market measure hemoglobin by chemically rupturing the red blood cells in a sablood cells in a sample.

In research funded by Sparks charity, Great Ormond Street Hospital Children's Charity and Cancer Research UK, researchers at the University of Cambridge have developed a test for blood and cerebrospinal fluid samples that looks for a specific panel of four pieces of short genetic code known as microRNAs, which are found in greater quantities in malignant germ cell tumours.

Over the course of three years, Horvath and his team analyzed nearly 8,000 tissue samples from these datasets, which included blood, saliva and cells from organs like the brain and the colon.

Schiffman and his team conducted another series of experiments in the laboratory on blood samples from adult African elephants to find how these genes respond to DNA damage in the elephant cells.

By varying the compositions of lipids, cues, and diffusible factors in the scaffolds, we engineered a very versatile and flexible platform that can be used to amplify specific T cell populations from blood samples, and that could be deployed in existing therapies such as CAR - T cell therapies,» said Mooney, Ph.D., a Core Faculty member at the Wyss Institute and leader of its Immunomaterials Platform.

Researchers have used radioimmunotherapy (RIT) to destroy remaining human immunodeficiency virus (HIV)- infected cells in the blood samples of patients treated with antiretroviral therapy, offering the promise of a strategy for curing HIV infection.

But about 20 years ago, researchers started noticing that the levels of cytokines and T - cells, which help drive immune responses and secrete cytokines, were higher instead of lower in blood samples from people diagnosed with depression.

The team compared a sample of fresh red blood cells with cells that looked spiky because their energy stores had been depleted.

Researchers of KIT and the Center for Nanotechnology (CeNTech), Münster, have now developed a clinical method to reliably detect and isolate single cancer cells in blood samples in cooperation with the University Hospital of Hamburg - Eppendorf (UKE).

The team's next avenue of research will be focused on identifying a «biomarker» that can identify this distinct suppressive cell elsewhere in the body — for example, in blood or other samples — as a potential predictive clinical tool to determine when these cells are present in patients, which currently can not be done.

The team used a statistical model of T cell receptor formation to analyze receptor DNA sequences in blood samples from adult pairs of identical twins.

Cheng, an assistant professor of medicine in hematology / oncology at Feinberg, provided the cell lines and NanoFlare targets the researchers used to model blood samples taken from breast cancer patients.

Many medical tests require samples of plasma without components like red and white blood cells, including those for cholesterol and glucose levels and immune deficiencies.

In a comprehensive and complex molecular study of blood samples from Ebola patients in Sierra Leone, published in Cell Host and Microbe, a scientific team led by the University of Wisconsin - Madison has identified signatures of Ebola virus disease that may aid in future treatment efforts.

After 3 months, the researchers drew blood samples from the monkeys, purified five different types of immune cells, and measured gene expression across their entire genomes.

The research team used blood samples taken daily throughout the patient's hospitalization and recovery to measure the rise and decline of virus replication inside white blood cells and serum and to track the timing, intensity and duration of expression of numerous immune system genes.

«Our circulating tumor cell device can release a tumor cell captured from a blood sample, enabling single cell analysis,» says Liu.

CEPH's idea was to develop a reference panel of large families, taking blood samples from each of their members to build up a cell bank for genetic typing.

Toner pumped samples of whole blood through the channels, which were coated with an antibody designed to trap any cancer cell that carries a common surface protein, much as flypaper snags pesky insects.

The researchers identified the LSC17 score by sampling the leukemia stem cell properties of blood or bone marrow samples from 78 AML patients from the cancer centre combined with molecular profiling technology that measures gene expression.

Capture experiments were also performed on whole blood samples, and the capture efficiency was in a high range of 81 - 95 %, at different tumor cell concentrations.

Palsson and his team were interested in red blood cells because they are the simplest human cells and are readily available from blood samples.

For example, cancer cells floated above denser blood cells, which could allow clinicians to spot rare circulating tumor cells in a patient sample.

To make the vaccine, researchers took a sample of a patient's tumors, which in this trial were made up of B cells (white blood cells that help the body battle disease and infection).

The role of rebiopsy and repeat analysis in the setting of post-treatment relapse, along with testing of blood samples for mutations in circulating tumor cells, cell free tumor DNA, or exosomes will be considered.