Sentences with phrase «blood cells age»

Normally, as red blood cells age or are damaged, they are broken down by other cells, called «macrophages.»

Measuring fluctuations over time, researchers found that the membrane stiffens as red blood cells age, impeding cell operation.

«We expected that blood cell age was an important factor... but we were surprised to find that it can explain all of the inaccuracy of the current test,» said Higgins.

Not exact matches

Novartis» experimental product, CTL019, is being recommended for children and young adults aged 3 to 25 who have hard - to - treat (or recurring) forms of the rare blood cancer B - cell acute lymphoblastic leukemia (ALL).

It is what spurs the association to endorse us because they have all these athletes that have aged blood cells and acidic bodies that have depleted all these minerals.

Finally, it could be shown that low regulatory T - cell numbers in umbilical cord blood was an indication that children exposed to tobacco smoke were more likely to develop an allergy before the age of three compared to those children with normal values for miR - 223 and Treg cells.

The boosted genes had three main beneficial effects: improving the efficiency of mitochondria, the powerhouse of cells; boosting insulin production, which improves control of blood sugar; and preventing the depletion of telomeres, caps on chromosomes that help to keep DNA stable and so prevent cells wearing out and ageing.

The boosted genes had three main effects: improving cellular energy efficiency; upping insulin production, which improves control of blood sugar; and preventing the breakdown of caps on chromosomes that help prevent cells wearing out and ageing.

To find out, the researchers injected a cloned telomerase gene into cultured cells from retina, skin, and blood vessels, all of which are associated with degenerative, aging - related diseases.

Moreover, whereas the blood vessel cells that resulted could also form capillarylike structures, they and the retinal cells aged prematurely, losing their ability to divide.

«Our studies show that mutations in our white blood cell cells, that we acquire as we age, may cause cardiovascular disease.

They specifically studied the length of telomeres (repeated DNA sequences) on the ends of chromosomes in leukocytes (white blood cells); the protective caps are believed to be markers of biological aging, because they shrink over time.

Meanwhile, recent human studies indicate that aging is associated with an increase in somatic mutations in the hematopoietic system, which gives rise to blood cells; these mutations provide a competitive growth advantage to the mutant hematopoietic cells, allowing for their clonal expansion — a process that has been shown to be associated with a greater incidence of atherosclerosis, though specifically how remains unclear.

How sleep apnea is related to these conditions is debated, but Cavadas and her co-authors propose that prolonged disruptions in blood oxygen levels and sleep fragmentation can generate stem cell exhaustion, epigenetic changes, increased inflammation, and other hallmarks of aging.

Because older red blood cells have had more time to pick up sugar in the blood, they can potentially skew the A1C test result, which averages glucose across red blood cells of all ages in the bloodstream.

Two years ago, he and his colleagues reported in Aging Cell that cutting the calories ingested by mice by 30 % for up to 4 weeks protected the rodents» kidneys when their blood supply was cut off and then restored.

This method would also enable them to follow potential aging processes that occur in blood stem cells in detail as they occur naturally in a living organism.

Being overweight or obese has been known to increase the risk of multiple myeloma, a cancer of the plasma cells in the blood and bone marrow that develops more often after age 60.

By taking the age of patients» blood cells into account, the researchers» model, when tested in more than 200 diabetic patients, reduced the error rate from one in three patients with the standard blood test to an error rate of one in 10.

Analyzing immune cells in umbilical cord blood from 1074 infants, Zhang and colleagues found that babies who showed hyperactive innate immune responses at birth went on to develop a food allergy when tested at age one.

The researchers pinpointed the age of blood cells in different patients as the major source of A1C variation.

To determine the age of the blood cells, Higgins and his colleagues developed an equation that compares glucose levels obtained by the A1C test with another method called continuous glucose monitoring.

They received either a saline placebo or plasma — blood from which the red cells have been removed — from blood donors aged 18 — 30.

Women who smoked a pack a day for 40 years added as much as 7.4 years to their blood cells» age.

Fat accelerates aging After examining 1,122 adult women, molecular biologist Tim Spector of St. Thomas» Hospital in London concluded that extra pounds can age white blood cells as much as 8.8 years.

Stem cell biologist Amy Wagers and cardiologist Richard Lee, both of the Harvard Stem Cell Institute, wondered if any circulating factors, in young blood, such as hormones, might affect aging heacell biologist Amy Wagers and cardiologist Richard Lee, both of the Harvard Stem Cell Institute, wondered if any circulating factors, in young blood, such as hormones, might affect aging heaCell Institute, wondered if any circulating factors, in young blood, such as hormones, might affect aging hearts.

«The effect of the precursors that boost NAD is to counteract the decline that occurs with normal aging, to reactivate SIRT1, and to restore function in endothelial cells to give rise to more blood vessels.»

Until then, he had devoted himself precociously to the heart, publishing his first scientific paper, on damage to red blood cells from open - heart surgery, at age 17.

Lymphomas are caused by an abnormal proliferation of white blood cells and can occur at any age.

Then there's the West Palm Beach symposium, held to recruit participants for a study testing what happens when aging people get infusions of plasma (the fluid part of blood packed with signaling proteins and other molecules but no red or white cells) from young people who've taken a drug meant to activate their immune system.

As we age, fat and blood cells form hard plaques on the walls of our arteries.

Age - related decline of neurogenesis and cognitive function is associated with reduced blood flow and decreased numbers of neural stem cells.

They showed that stress in pancreatic cells due to sleep deprivation may contribute to the loss or dysfunction of these cells important to maintaining proper blood sugar levels, and that these functions may be exacerbated by normal aging.

Blood cells stored for transfusion also change shape as they age.

«We studied human T cells, isolated from blood donors of all ages, to compare mature cytotoxic T cells with naive ones,» said Philip Ansumana Hull, graduate student in Ott's lab and one of the first authors of the study.

Both anemia and low hemoglobin levels, which are proteins in red blood cells that carry oxygen throughout the body, are also common in older people, said Phyo Myint, M.D., senior study author and Professor of Medicine of Old Age at the University of Aberdeen in Scotland.

Aging is a key risk factor for sAML because, over time, hematopoietic stem cells (which give rise to all other blood cell types) accumulate DNA mutations and changes in other molecules that put DNA instructions into action, such as RNA and proteins.

Although we did observe positive effects on some aging traits, such as memory impairments and reduced red blood cell counts, our studies showed that similar drug effects are also seen in young mice, indicating that rapamycin did not influence these measures by slowing aging, but rather via other, aging - independent, mechanisms.»

«These splicing signatures could potentially be used as clinical biomarkers to detect blood stem cells that show signs of early aging or leukemia, and to monitor patient responses to treatment,» said Crews.

Previous studies have shown that white blood cell telomere length can be predictive of biological aging and is linked with telomere length in other cells in the body.

They found that women with the lowest number of eggs also had the shortest telomeres — the chromosome caps that wear away as cells age — in their white blood cells.

Jamieson's team wanted to understand how RNA might change with the aging of normal blood stem cells compared with sAML stem cells.

Scientists at King's College London have found that people who have previously suffered from acne are likely to have longer telomeres (the protective repeated nucleotides found at the end of chromosomes) in their white blood cells, meaning their cells could be better protected against aging.

In addition, recipients of red blood cells from donors aged 20 - 30 were associated with a six percent increased risk of death per transfused product compared with recipients of red blood cells from donors aged 40 - 50.

NO BARRIER A protein in some cells that form the blood - brain barrier (light blue, as seen in this image of a mouse brain capillary) may have a hand in brain aging, a new study suggests.

Recipients of blood from donors aged 17 - 20 were associated with an eight percent increased risk of death per unit transfused compared with recipients of red blood cells from donors aged 40 - 50.

But as the blood stem cells age, their ability to regenerate blood declines, potentially contributing to anemia and the risk of cancers like acute myeloid leukemia and immune deficiency.

That's because experiments conducted on the International Space Station involving cells that line the inner surfaces of blood vessels (endothelial cells) show that microgravity accelerates cardiovascular disease and the biological aging of these cells.

With use of advanced mouse models, she and her team found that blood stem cells without adequate SIRT1 resembled aged and defective stem cells, which are thought to be linked to development of malignancies.

The investigators also plan to look at whether SIRT1 therapy could treat diseases already linked to aging, faulty blood stem cells.