Sentences with phrase «blood cells engineered»

Not exact matches

Technology by Cellectis allows cellular engineering, and a human trial of the company's work in editing blood cells will be presented at the upcoming American Society of Hematology.

On an additional project with former MIT graduate student Eric Grovender, Ameer co-developed a cartridge filter that purifies blood, «based on protein and cell engineering,» for those suffering from chronic kidney failure.

An engineered bone that has its own marrow can encourage donor stem cells to produce blood, a feat that could help people with anaemia and rare immune diseases

Cells engineered to produce insulin under the command of a smartphone helped keep blood sugar levels within normal limits in diabetic mice, a new study reports.

It plans to use Crispr for engineering immune cells and blood stem cells, and as a research tool for drug discovery.

«In addition to protecting the islets, our engineered material promotes the formation of new blood vessels to nourish the cells.»

The cells used to build the organs could be cultured from stem cells taken from fat or bone - marrow tissue, he says: «We could engineer a blood vessel from your own cells.»

In March 2016, Penn researchers published a study in Blood that showed long - term ibrutinib treatment reverses the dysfunction of T cells in CLL and that combining CAR therapy with ibrutinib enhanced engineered T cell proliferation in mice.

The goal of the multi-institutional team is to develop genome engineering - based methods for correcting the disease - causing mutation in each patient's own stem cells to ensure that new red blood cells are healthy.

Researchers have harnessed the CRISPR - Cas9 technology to correct mutations in the blood stem cells of patients with a rare immunodeficiency disorder; the engineered cells successfully engrafted in mice for up to five months.

Moreover, mice engineered to generate smaller than normal quantities of SIRT1 carried relatively little fat in their blood, indicating that their cells hung onto it.

By varying the compositions of lipids, cues, and diffusible factors in the scaffolds, we engineered a very versatile and flexible platform that can be used to amplify specific T cell populations from blood samples, and that could be deployed in existing therapies such as CAR - T cell therapies,» said Mooney, Ph.D., a Core Faculty member at the Wyss Institute and leader of its Immunomaterials Platform.

In addition, harmine treatment tripled the number of beta cells and led to better control of blood sugar in three groups of mice engineered to mimic human diabetes.

The researchers created the nanosponges by separating the membranes of human red blood cells from their internal contents and stabilizing the membranes with an engineered core designed to absorb the toxins produced by pathogenic bacteria.

Through gene therapy, researchers engineered blood - forming stem cells (hematopoietic stem / progenitor cells, or HSPCs) to carry chimeric antigen receptor (CAR) genes to make cells that can detect and destroy HIV - infected cells.

In experiments with genetically engineered mice that lacked beta cells, reprogrammed stomach cells pumped out insulin and glucose at normal levels in the blood.

Researchers have been seeking a way to improve the body's ability to combat the virus by engineering blood - forming stem cells to specifically target and kill HIV - infected cells for the life of the individual.

Recently, scientists have engineered cells from a patient's own immune system to fight blood cancers.

Immune cell therapies using engineered T - cells have recently emerged as successful treatments for some blood cancers, which are referred to as «liquid» tumors.

«Our group pioneered the development of cell culture technology for harvesting large numbers of stem cells from human bone marrow and human umbilical cord blood,» Dr. Yeh said, noting that stem cells from these two sources are abundant and can be guided into different types of cells using tissue engineering.

Plasma from old mice didn't have a strong effect when injected into young mice genetically engineered to lack VCAM1 in certain blood - brain barrier cells.

In an effort to overcome these limitations, a team at the Wyss Institute for Biologically Inspired Engineering led by its Founding Director, Donald Ingber, M.D., Ph.D., had previously engineered a microfluidic «Organ - on - a-Chip» (Organ Chip) culture device in which cells from a human intestinal cell line originally isolated from a tumor were cultured in one of two parallel running channels, separated by a porous matrix - coated membrane from human blood vessel - derived endothelial cells in the adjacent channel.

T cells are collected from the patient's blood and genetically engineered to express cell - surface proteins called CARs, which recognize specific molecules found on the surface of cancer cells.

By engineering red blood cells to have «sticky» proteins on their surface, a team of researchers has given the cells the ability to carry anything from drugs to treat immune disorders or cancer to radioactive molecules used in imaging of blood vessels.

These cells were genetically engineered to produce greater amounts of nitric oxide, a natural substance that widens blood vessels and is essential for efficient vascular repair and regeneration.

Those engineered proteins remained as the erythroblasts matured into red blood cells.

Red blood cells have been genetically engineered to make it easy to stick molecules to them, and so could safely deliver drugs where needed

Dr. Sadelain's research focuses on human cell engineering and cell therapy to treat cancer and hereditary blood disorders.

A chip developed by mechanical engineers at Worcester Polytechnic Institute (WPI) can trap and identify metastatic cancer cells in a small amount of blood drawn from a cancer patient.

The trial participants had T cells removed from their blood and then modified in the laboratory with a designer enzyme engineered by Sangamo BioSciences in Richmond, California.

Cornell biomedical engineers have developed specialized white blood cells - dubbed «super natural killer cells» - that seek out cancer cells in lymph nodes with only one purpose: destroy them.

A model of a malaria - infected red blood cell may lead to better ways to treat malaria, according to a team of engineers and molecular biologists who investigated how this parasite infection causes the red blood cells to stiffen.

In the study, the biomedical engineers killed the cancerous tumor cells within days, by injecting liposomes armed with TRAIL (Tumor necrosis factor Related Apoptosis - Inducing Ligand) that attach to «natural killer» cells — a type of white blood cell — residing in the lymph nodes.

We still have our flesh and blood cells, but we soup them up with nanotech brain chips, genetic engineering and these sorts of things.

These drugs free a patient's immune system from cancer - induced suppression, while others engineer a patient's own white blood cells to attack cancer.

Right now, in our laboratories, our scientists are looking for ways to create insulin - producing cells in the laboratory, engineer blood vessels for heart bypass surgery and apply our regenerative medicine technologies to battlefield injuries through co-leading a $ 85 million federal grant, as well as many other novel research initiatives.

To produce CAR T - cells, doctors send a patient's blood to a lab where technicians isolate T - cells and engineer them to produce chimeric antigen receptors, or CARs.

For the other adult patients that might still benefit from a cord blood donor, either two cord blood units are combined for a single transplant, or more recently, there are some exciting new graft engineering technologies that are emerging to expand stem or progenitor cells in the laboratory before infusion or modify the cells in some way to make them more potent at the time of transplant.

Using an assortment of engineered and non-engineered mice, the researchers looked specifically at the role of T cells (white blood cells that play a key role in immunity).

«We have demonstrated that engineered blood vessels prepared with smooth muscle progenitor cells from hair follicles are capable of dilating and constricting, critical properties that make them ideal for engineering cardiovascular tissue regeneration,» said Andreadis.

For a rich source of stem cells to be engineered into new blood vessels or skin tissue, clinicians may one day look no further than the hair on their patients» heads, according to new research published earlier this month by University at Buffalo engineers.

A team of researchers has engineered smart protein molecules that can reprogram white blood cells to ignore a self - defense signaling mechanism that cancer cells...

Andreadis and his colleagues previously engineered functional and implantable blood vessels with smooth muscle and endothelial cells originating from bone - marrow mesenchymal stem cells.

CAR T - cells are genetically modified white blood cells that have been engineered to specifically attack a patient's cancer.

SAN DIEGO, March 28, 2017 (GLOBE NEWSWIRE)-- Invivoscribe ® Technologies Inc., a global company with decades of experience providing internationally standardized clonality and biomarker testing solutions for the fields of oncology, personalized molecular diagnostics ®, and personalized molecular medicine ®, reports that its next - generation sequencing (NGS) LymphoTrack ® Assay kits are being used by its LabPMM ® clinical laboratories, pharmaceutical partners, and cancer centers to identify and monitor chimeric antigen receptor T - cells (CAR - T) and engineered T - cell receptors in peripheral blood of subjects in support of immuno - therapeutic drug development and treatment regimen development for both hematologic and solid tumors.

As noted above, existing cancer vaccines that use dendritic cells require extracting cells from a patient's blood, treating them with an engineered protein or nucleic acid that combines tumor antigens with immune - stimulating molecules, and returning the activated dendritic cells to the patient.

Using CRISPR, the paper, published in the journal Blood, describes how genetic deletion of the T cells» endogenous receptor eliminates the competition it imposed on the engineered TCR and the possibility of dangerous hybrid TCR formation.

Tactiva's lead platform is a unique approach to adoptive cell transfer (ACT), a form of immunotherapy in which a patient's own immune cells are drawn from blood, genetically engineered, multiplied and injected back into the patient in order to launch a powerful attack against cancer.

Utilizing sophisticated genetically engineered mouse models, we will study how these conserved longevity pathways regulate the homeostasis and aging of adult stem cells, including hematopoietic stem cells, the adult stem cells that sustain all blood lineages throughout life.

Maia Szalavitz reports: «These glowing animals have been genetically engineered to make blood cells that are resistant to feline immunodeficiency virus, or FIV, the virus that causes...