A solution, Cheng and his colleagues thought, could be to grow
blood cells in the lab that were matched to each patient's own genetic material and thus could evade the immune system.
Not exact matches
This new kind of approach to fighting
blood cancers is truly personalized; immune T -
cells are extracted from patients, genetically tinkered to home
in on an destroy cancerous
cells, multiplied
in a
lab, and then jolted back into the patient's body within about two weeks.
In lab dishes, the blast
cells formed tissues that resembled
blood - forming stem
cells as well as
blood vessels, the group found.
Rahul Palchaudhuri, a postdoctoral fellow
in Scadden's
lab and first author on the paper, armed CD45 - targeting antibodies with a payload that destroys only existing
blood cells.
Shane Mayack was a postdoc
in the
lab of Amy Wagers at Harvard University's Joslin Diabetes Center, studying
blood stem
cells.
I couldn't resist composing this after the mention of the charmingly misspelled word «hematopoetic»
in your story on
blood grown
in the
lab from stem
cells (12 November, p 8):
Researchers
in the Rice
lab of chemist and bioengineer Jeffrey Hartgerink had just such an experience with the hydrogels they developed as a synthetic scaffold to deliver drugs and encourage the growth of
cells and
blood vessels for new tissue.
So far Kajander and his colleagues have found the nanobacteria
in cattle
blood,
in 80 % of samples of commercial cow serum
in which mammalian
cells are grown
in the
lab, and
in the
blood of nearly 6 % of more than 1000 Finnish adults tested.
And his group has applied for funding to run
lab studies to see if the fish hosting blotchy lesions develop more subtle — and disturbing — symptoms with time, such as a slower swimming speed or changes
in blood -
cell counts.
Tanyi and colleagues made each patient's vaccine by sifting through the patient's own peripheral
blood mononuclear
cells for suitable precursor
cells, and then growing these,
in the
lab, into a large population of dendritic
cells.
Transplants grown from stem
cells in the
lab can help replenish the
blood and have been used to cure anaemia
in mice.
The implications were hardly lost on the Bethesda crowd: If the virus was transmitted
in cell cultures
in Ruscetti's
lab, it could also be contaminating the nation's
blood supply as a result of
blood donations from unknowingly infected donors.
Around 2000, then - postdoc Wagers and other researchers
in Irving Weissman's and Thomas Rando's
labs at Stanford revived the method, known as parabiosis, to study the fate of
blood stem
cells and muscle
cells.
«This development has the potential to enable earlier detection of solid tumors through a simple
blood draw by substantially improving our ability to detect very low quantities of circulating DNA derived from tumor
cells,» says corresponding author Hunter Underhill, M.D., Ph.D., who initiated the research while
in the
lab of senior author Jay Shendure, M.D., Ph.D., a professor
in genome sciences at the University of Washington.
As with the other self - diagnosis tools, home use of Ozcan's
cell phone
blood imager is a ways off, but it is already being looked at for pilot programs
in remote locations where doctors and
lab equipment are
in short supply.
«We studied human T
cells, isolated from
blood donors of all ages, to compare mature cytotoxic T
cells with naive ones,» said Philip Ansumana Hull, graduate student
in Ott's
lab and one of the first authors of the study.
In lab tests the refurbished cells cured the disease in mice and in human bloo
In lab tests the refurbished
cells cured the disease
in mice and in human bloo
in mice and
in human bloo
in human
blood.
Part of the issue was settled when Cecilia Riquelme, a postdoc
in Leinwand's
lab, drew
blood from recently fed pythons and applied it to a dish of living rat heart
cells.
Using stem
cells from umbilical cord
blood, researchers are growing clusters of real liver
cells in the
lab.
Dr. Gabriel Ferguson, a postdoctoral fellow
in the
lab of Dr. Martinez - Agosto and first author of the study, built upon the
lab's previous research that utilized the
blood system of the fruit fly species Drosophila, showing that a specific set of signals must be received by progenitor
cells to activate their differentiation into
cells that can work to fight infection after injury.
Additional problems cropped up
in March, however, when New Scientist reported that a single image had appeared three different times
in data from Verfaillie's
lab — once referring to bone and once to cartilage
in a 2001
Blood paper about human MAPCs, and once again to describe bone
cells in a 2006 patent application.
Liu's «
lab on a chip» is notable for its ability to not only capture tumor
cells circulating
in the
blood, but to «release» those
cells as well.
When the team tested the drug on
cells grown
in the
lab, they found that it killed
blood vessel
cells and prevented growth of new
blood vessels.
Labs can test their proficiency at carrying out the polymerase chain reaction (PCR), a technique that generates usable quantities of DNA from
cells in a tiny sample of
blood or semen.
RED
blood cells generated
in a
lab have been successfully injected into a human volunteer for the first time.
To find out if this was true, workers
in stem -
cell biologist Irving Weissman's
lab at Stanford University Medical School took one
blood stem
cell from an adult mouse and tagged it with a marker that glowed green under fluorescent light.
«The
blood - brain barrier forms pretty early
in gestation, so the thyroid hormone, even from the mother, is probably not getting through the barrier and into the brain, likely leading to developmental deficits,» says Shusta, whose group was among the first to develop
blood - brain barriers from patient - derived stem
cells in the
lab dish.
In lab dishes, Liu's team corrected a mutation in human cells from a patient with an iron - storage blood disorder called hereditary hemochromatosi
In lab dishes, Liu's team corrected a mutation
in human cells from a patient with an iron - storage blood disorder called hereditary hemochromatosi
in human
cells from a patient with an iron - storage
blood disorder called hereditary hemochromatosis.
Johannes Scheid, a student
in Nussenzweig's
lab, isolated it several years ago from an HIV - infected patient whose immune system had an exceptional ability to neutralize HIV
in the
blood by preventing the virus from infecting and destroying a specific type of immune
cells, called CD4
cells,
in patients.
Berkeley
Lab researchers found that the sticky residue left behind by tobacco smoke led to changes
in weight and
blood cell count
in mice.
Hungerford, a predoctoral fellow, was writing his doctoral thesis on chromosomes
in a genetics
lab at Fox Chase Cancer Center, and detected a tiny flaw
in chromosomes from the
blood cells of patients with a type of leukemia.
In the new papers, according to STAT, scientists will report that the organoids survived for extended periods of time — two months in one case — and even connected to lab animals» circulatory and nervous systems, transferring blood and nerve signals between the host animal and the implanted human cell
In the new papers, according to STAT, scientists will report that the organoids survived for extended periods of time — two months
in one case — and even connected to lab animals» circulatory and nervous systems, transferring blood and nerve signals between the host animal and the implanted human cell
in one case — and even connected to
lab animals» circulatory and nervous systems, transferring
blood and nerve signals between the host animal and the implanted human
cells.
Postdoctoral positions are available
in Dr. Sarah Yuan's
lab studying
blood / vascular
cell biology wi...
In that condition, stem cells collected from the blood or bone marrow could be removed from a patient, edited in the lab to correct the DNA typo — a process called «ex vivo» gene editing — and then reinjected to proliferate and make a patient health
In that condition, stem
cells collected from the
blood or bone marrow could be removed from a patient, edited
in the lab to correct the DNA typo — a process called «ex vivo» gene editing — and then reinjected to proliferate and make a patient health
in the
lab to correct the DNA typo — a process called «ex vivo» gene editing — and then reinjected to proliferate and make a patient healthy.
Corn's
lab is one of several using CRISPR to cure — at least
in isolated
cells and mice — sickle
cell disease, where a single - letter DNA mutation stymies the oxygen - ferrying capacity of red
blood cells.
These
cells are extracted from monkeys, altered with CRISPR
in a
lab, and then later infused back into the monkey's marrow to grow and make new, healthy
blood cells.
The
blood is efficiently separated so that mononuclear white
blood cells and peripheral
blood stem
cells can be transferred to a collection bag which will be transferred to the
lab and frozen for later use
in adult stem
cell therapy.
By examining the results of genome - wide association studies (GWAS)
in conjunction with experiments on mouse and human red
blood cells (RBCs), researchers
in the
lab of Whitehead Institute Founding Member Harvey Lodish have identified the protein cyclin D3 as regulating the number of
cell divisions RBC progenitors undergo, which ultimately affects the resulting size and quantity of RBCs.
The King
Lab has pioneered the use of selectin proteins to deliver apoptosis death signals to tumor
cells in flowing
blood, and to deliver therapeutic cargo (e.g., siRNA, chemotherapeutics) encapsulated
in nanoscale liposomes.
Scientists from BloodSystems Research Institute
in San Francisco, California, and Canadian
Blood Services» Centre for Innovation lab in Edmonton, Alberta, report that specific red blood cell manufacturing methods may be less damaging to cells than ot
Blood Services» Centre for Innovation
lab in Edmonton, Alberta, report that specific red
blood cell manufacturing methods may be less damaging to cells than ot
blood cell manufacturing methods may be less damaging to
cells than others.
Researchers at Boston Children's Hospital have, for the first time, generated
blood - forming stem
cells in the
lab using pluripotent stem
cells, which can make virtually every
cell type
in the body.
Chunhui Xu's
lab in the Department of Pediatrics recently published a paper
in Stem
Cell Reports on the differentiation of endothelial
cells, which line and maintain
blood vessels.
The common
blood tests listed
in the chart below are among the most helpful to understand, but keep scrolling to see guides to many other
lab tests, such as white
blood cell readings and cholesterol / lipid panels.
It is prescribed for edema
in Germany and may be safer than other remedies because it replenishes potassium.910 Preliminary animal studies suggest that dandelion may help normalize
blood sugar and fight inflammation.11 Dandelion root extract caused cancer
cells to destroy themselves
in a Canadian
lab study, which prompted a clinical study (the results of which are not yet available).12
We have a comprehensive
in - house
lab that allows for rapid analysis of white and red
blood cell values, electrolytes, and parameters of organ function.
The bone marrow should respond to anemia by producing more red
blood cells; therefore, an increase
in the number of immature
cells called reticulocytes should be seen on
lab results.
Lab Technician II — TRL Plasma Laboratories — January 2013 — Present • Monitor the heat sealing and aseptic sampling of plasma units; place units of plasma into freezer
in timely manner
in order to ensure quality of product • Label plasma samples and units properly and store according to policy; manage an average of 50 different plasma units on a regular basis • Evaluate refrigerator and freezer temperatures ad inform supervisor if equipment is malfunctioning • Maintain efficient and clean work environment and ensure inventory is stocked properly; answer phones and answer questions or transfer calls to appropriate departmentLab Technician I — ABC Medical Technologies, Inc. — May 2007 — January 2013 • Operated laboratory equipment, such as
cell counters and microscopes, to analyze urine,
blood, and tissue samples; recorded both normal and abnormal findings; had less than a.1 percent margin of error
in sample findings • Used computerized instruments and automated equipment to perform multiple tests at one time; maintained calibration and proper function of equipment on a regular basis • Entered data from tests into physician reports; discussed abnormal results with supervisor and re-ran tests before logging data into patient's medical record
Lab Technician — ABO Laboratories — May 2012 — Present • Execute a variety of laboratory assays and tests
in accordance with established procedures, policies, and regulations; ensure samples are properly labeled and stored • Study
blood samples for transfusions and record the
blood group, number of
cells,
blood type,
cell morphology, and other
blood type compatibility • Perform procedural and instrument calibrations, document all quality control activities, and perform regular equipment maintenance • Identify problems that may negatively affect test results or performance; correct issues immediately and properly notify supervisor • Maintain meticulous records and demonstrate that the testing of samples is done
in the same manner as patient specimens; promote cost - effective testing practices and reduce waste by 10 percent
Hysi's research also included a review of Dr. Gottman's Love
Lab studies, which found higher white
blood cell counts
in couples that were happily married.