Sentences with phrase «blood cells target»

Until this week, the WHO recommended that HIV treatment should begin when each millilitre of an infected person's blood contains fewer than 350 CD4 cells, the white blood cells targeted and destroyed by HIV.

Currently, the WHO recommends that HIV treatment should not begin for most infected people until each cubic millimetre of their blood contains fewer than 350 CD4 cells, the white blood cells targeted and destroyed by HIV.

The cut - off point for the numbers of the white blood cells targeted by the virus had been 200.

Not exact matches

Consider: Last year alone, the FDA approved two treatments, from Novartis and Gilead, that literally reengineer patients» immune T - cells to target and destroy blood cancers.

Most of the action is coordinated by white blood cells, which direct the lines of attack like football coaches, churning out antibodies that target the opponent for destruction.

Biotech giant Gilead Sciences is beefing up its cancer drug portfolio with a $ 11.9 billion deal to buy Kite Pharma, a company focused on a groundbreaking new class of treatments that turns the body's own immune cells into targeted blood cancer killers.

While coffee targets the fat cells, the scrub exfoliates your skin, boosts blood circulation and minimizes cellulite.

The Zika virus can cross the blood - brain barrier, and could target cancer cells, sparing normal adult brain tissue and opening a potential new way to attack the disease.

If we can learn lessons from Zika's ability to cross the blood - brain barrier and target brain stem cells selectively, we could be holding the key to future treatments.»

«Few drugs have the capacity to cross the tumor blood - brain barrier and specifically target tumor cells,» says principal investigator Balveen Kaur, PhD, associate professor of neurological surgery and chief of the Dardinger Laboratory of Neurosciences at the OSUCCC — James.

One class of immunotherapeutic drugs is known as «checkpoint» inhibitors, as they target checkpoints in immune system regulation to allow the body's natural defenses, such as white blood cells, to more effectively target the cancer.

The laboratory and animal study also shows how the agent, called SapC - DOPS, targets tumor cells and blood vessels.

A preclinical study shows that an experimental nanotechnology drug called SapC - DOPS crosses the tumor blood - brain barrier, targets brain - tumor cells and retards growth of tumor blood vessels.

They cross the blood - brain / blood - tumor barrier, and accumulate within brain tumor sites, where they target oncogenes, regulate cell growth and differentiation, reduce tumor burden and prolong survival in our mouse models.»

Rahul Palchaudhuri, a postdoctoral fellow in Scadden's lab and first author on the paper, armed CD45 - targeting antibodies with a payload that destroys only existing blood cells.

«Injecting the human blood cells resulted in massive liver cell damage and we were able to detect cytotoxic T lymphocytes that specifically targeted hepatitis B virus in liver infiltration cells.

Researchers are still somewhat uncertain about exactly how it works, but they know that it targets the parasite as it infects red blood cells.

In the study, exosomes, which are generated by all cells and are naturally present in blood, were modified as «iExosomes,» capable of delivering small RNA to specifically target mutant KRAS, resulting in disease suppression and increased overall survival in mouse models.

They found that hepatitis in these «human hepatocyte chimeric mice» was caused by white blood cells known as cytotoxic T lymphocytes (CTLs) that were specifically targeted to hepatitis B virus.

In a study recently published in the journal Nature Biotechnology, HSCI researchers at Harvard University and Massachusetts General Hospital (MGH), in collaboration with Boston Children's Hospital and Dana Farber Cancer Institute, have developed a non-toxic transplantation procedure using antibodies to specifically target blood stem cells in mice, an approach they hope will make blood stem cell transplants for these patients far less toxic.

In human donor cells and mouse experimental models, the researchers demonstrated that TSLP specifically targeted neutrophils — white blood cells that constitute the first line of defense against bacterial infections.

The former target, say, using gene editing techniques to inactivate HIV receptors and achieve resistance of blood cells to the virus (which Sangamo BioSciences is working on in clincial trials) is different than helping parents who both carry genes for Huntington's Disease to have a child that is free of the disease (a change to the genome that would be passed on to future generations and would likely not be very commonly needed).

In other words, the same «old» medicine simultaneously targets the cancer cells themselves and the blood vessels with great efficiency.

Blood testing showed an expansion in the numbers of CD19 - targeted CAR T - cells that coincided with the tumor's regression.

Participants with high - risk bacterial communities, which are commonly found in the population of women studied, also had increased numbers of genital CD4 + T cells — white blood cells that are HIV's primary target.

Other vaccines in trials target the blood - cell stage, and contain a parasite protein called AMA - 1, meant to prime the body's immune system to attack it.

The new device will allow for more accurate medical procedures that involve the use of ultrasound to kill tumours, loosen blood clots and deliver drugs into targeted cells.

Other ongoing stem cell trials are targeting blood disorders like aplastic anemia, leukemia, lymphoma, and, of course, sickle - cell disease.

Nor can his organoids be used to test drugs targeting blood vessels or immune cells because organoids have neither.

Researchers have been seeking a way to improve the body's ability to combat the virus by engineering blood - forming stem cells to specifically target and kill HIV - infected cells for the life of the individual.

Cheng, an assistant professor of medicine in hematology / oncology at Feinberg, provided the cell lines and NanoFlare targets the researchers used to model blood samples taken from breast cancer patients.

These investigations take advantage of white blood cells, monocytes, and macrophages that can target an inflammation site, including inside the brain.

In yet another approach, researchers could modify specific white blood cells (called T - cells) to see and target pancreatic cancer cells, although this therapy could attack healthy cells, too.

One approach is to give patients specific antibodies that target the homing devices (essentially chemical receptors) in white blood cells, rendering the tumor cells immunologically visible.

Oxygen is carried in hemoglobin, which travels the bloodstream to its target tissue inside typically flexible, oval - shaped red blood cells.

«Under no circumstances should it be concluded from our work that consumption of marijuana can be a way to cure diabetes,» Prof. Dobrzyn warns and explains: «The concentration of glucose in the blood is determined by the balance between the activities of alpha and beta cells of the pancreas and insulin target tissues such as skeletal muscle and adipose tissue.

Called the CTC - iChip system (the «i» is for «inertial focusing»), it targets blood cells instead of cancer cells.

The study also points to a potentially new therapeutic target, the self - adhesion molecule P - selectin, which the researchers found played a central role in increased red blood cell adhesion.

The researchers found that Zika targeted two specific cell types in mice: spermatogonia, which make sperm, and Sertoli cells, which are involved in helping sperm develop and sheltering them from the blood and immune system, building what's called the blood - testis barrier.

Such efforts could reveal more about how the parasite invades red blood cells and replicates inside cells, which could generate new drug and vaccine targets.

The human intestine has the highest concentration of HIV target cells, the majority of which are destroyed within days of infection, and before CD4 T cell counts drop measurably in the blood.

Snake and reptile venoms typically don't work for this type of research because most of them function as hemotoxins (which destroy red blood cells) and target components of the cardiovascular system, King says.

Professor Geoff Pilkington, study co-author and Head of the Brain Tumour Research Centre, said: «Although this work is still at an early stage, we have demonstrated key elements that are associated with tumour cell binding to blood vessels and this may provide a target for future drug development to prevent the development of secondary tumours in the brain.

Before the vaccination, only 4 % of the participants» cytotoxic T lymphocytes (a type of white blood cell that helps control infections) specifically targeted these conserved proteins; after vaccination, that jumped to 67 %.

Antibodies only bind to target cells Peptide antibodies developed by Kwak and co-discoverer, Hong Qin, Ph.D., assistant professor of Lymphoma / Myeloma, wipe out MDSCs in the blood, spleen and tumor cells of mice without binding to other white blood cells or dendritic cells involved in immune response.

«Because the hematopoetic stem cell niche is so important for the creation of bone marrow and blood cells and because Del - 1 is a soluble protein and is easily manipulated, one can see that it could be a target in many potential applications,» said George Hajishengallis, the Thomas W. Evans Centennial Professor in the Department of Microbiology in Penn's School of Dental Medicine and a senior author on the work.

They also coated them with a polyethylene glycol shell, which helps them survive longer in blood circulation and enter target cells.

A specific lung - targeting molecule is attached to the carrier's surface and the steriod, dexamethasone, an anti-inflammatory, is loaded into the nanogel, which then binds to lung endothelial cells lining the inside wall of the blood vessels where it rapidly delivers the drug.

«Blood cancers develop when immune cell DNA editing hits off - target spots: Team urges consideration of cutting - and - pasting errors when using enzymes for gene modification.»

One possibility, he says, is that the treatment doesn't kill blood vessels indiscriminately but targets only fine branches of vessels, putting fat cells under stress without destroying them.