This feedback
circuit is
composed of a single class of reward - signaling dopamine neurons (PAM - α1) projecting to a restricted region of the mushroom
body (MB), and a specific MB output cell type, MBON - α1, whose dendrites arborize that same MB compartment.
The homeostasis of
body weight regulation and hunger signaling is
composed of complex
circuits of both central signals including orexin, neuropeptide Y, melanin concentrating hormone and alpha - melanocyte, and peripheral signals from the gut and adipose tissue, such as ghrelin, peptide YY and leptin (75).