Rheumatoid arthritis (RA) is a disease mainly defined by its clinical features of chronic inflammation in joints associated with
bone and cartilage destruction.
Not exact matches
The therapies, hotly pursued by pharmaceutical companies, inhibit proteins called kinases,
and aim to halt the inflammation that causes debilitating pain
and eventual
destruction of
bone and cartilage.
Histopathology in Tg197 mice is characterized by infiltration of inflammatory cells, synovial hyperplasia, articular
cartilage destruction and bone erosion symptoms, closely resembling those of human rheumatoid arthritis.
Figure 2: Representative histology images of A: wild type
and B: Tg197 animals at 7 weeks of age depicting the symptoms of Infiltration of inflammatory cells, Synovial hyperplasia, Articular
cartilage destruction and Bone erosions evident as Tg5453 arthritic pathology.
Arthritis: Joints of TNFΔARE mice display severe pathological features of chronic symmetrical inflammatory polyarthritis, including hyperplasia of the synovial membrane, presence of inflammatory infiltrate,
bone erosion
and articular
cartilage destruction.
CHD is a developmental disease of the
bones in which the head of the thigh
bone poorly fits the hip socket, causing damage to the
cartilage, gradual
destruction of the joint, pain
and swelling.