Sentences with phrase «bone cell differentiation»
I think so because it's a disease that affects cartilage and bone cell differentiation.
https://www.scientificamerican.com/ Not exact matches
Such embryo research might teach us more about cell differentiation and early embryo development, it might make possible greater success in bone marrow transplants, and it might help us to treat more successfully degenerative diseases and spinal cord injuries.
Stem cells have also been identified in human milk, and have the potential to differentiate into mammary epithelial lineages under mammary differentiation conditions in vitro, as well as other cell types in corresponding microenvironments, including bone cells, brain cells, liver cells, pancreatic beta cells and heart cells.
Varghese and her team showed that they could control the differentiation of human pluripotent stem cells into functional osteoblasts — bone - building cells — simply by adding the molecule adenosine to their growth medium.
By monitoring stem cell differentiation on gels that mimic the stiffness and nanofibrous structure of biological tissue, researchers have identified the specific molecules that stem cells use when selecting bone and cartilage fates.
Damage occurs when metastatic tumor cells recruit pre-osteoclast cells to the bone and then induce their differentiation into mature bone - degrading cells, which results in the release of proteins from the bone matrix that promote tumor cell growth.
Research conducted at Japan's National Institute for Materials Science built on previous findings that gold nanoparticles can encourage stem cells in the bone marrow to differentiate into bone cells, and that specific biomolecules can inhibit or promote stem cell differentiation.
«We found that with increasing stress relaxation, especially combined with increased stiffness in the hydrogel, there is an increase of osteogenic — bone cell — differentiation,» said Luo Gu, postdoctoral fellow in the Mooney lab and co-first author.
Not only did increased stress relaxation dramatically increase early osteogenic differentiation but those cells continued to grow as bone cells weeks after their initial differentiation and formed an interconnected mineralized matrix rich in collagen, key structural features of bone.
Researchers in Japan have shown that modified gold nanoparticles can be used to control the differentiation of stem cells into bone.
«A better way to grow bone cells: New method allows for more control in the differentiation of stem cells into bone cells.»
The positively charged and neutral nanoparticles mildly inhibited stem cell proliferation but had no effect on their differentiation into bone cells.
They then used human stem cells derived from bone marrow that would normally become bone cells to test the effects of the nanoparticles on stem cell proliferation and differentiation.
The present study demonstrated that cancer - secreted microRNAs induced osteoblastic bone metastasis through promoting the osteogenic differentiation of bone - forming cells.
«Our experiments showed that restoring H19 expression hindered by too much p53 restored «protective differentiation» of osteoblasts to counter events of tumor growth early on in bone cancer,» said co-author, Ihor Lemischka, PhD, Director of The Black Family Stem Cell Institute within the Icahn School of Medicine.
The authors concluded that the CaP / gel / Ti implants fabricated using their urease process not only enhanced the proliferation of stem cells and differentiation of bone cells, but also the bone bonding ability of the implants.
Using human fat - derived stem cells from young (aged 24 - 36 years), middle - aged (aged 48 - 55 years) and elderly (aged 60 - 81) participants, the team used ECIS to collect complex measurements during the growth and differentiation stages the hASC exhibited as they converted to bone cells.
MicroRNA - 410 promotes chondrogenic differentiation of human bone marrow mesenchymal stem cells through down - regulating Wnt3a.
Human stem / progenitor cells from bone marrow enhance glial differentiation of rat neural stem cells: a role for transforming growth factor β and Notch signaling.
Lee et al., Epigenetic - mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastomas - initiating cells.
Differences between in vitro viability and differentiation and in vivo bone - forming efficacy of human mesenchymal stem cells cultured on PCL - TCP scaffolds.
Porcine bone marrow stromal cell differentiation on heparin - adsorbed poly (e-caprolactone)- tricalcium phosphate - collagen scaffolds.
Orai1 mediates osteogenic differentiation via BMP signaling pathway in bone marrow mesenchymal stem cells.
Comparison of the differentiation potential of cell populations isolated from human lipoaspirate, trabecular bone tissue and periosteal tissue.
«What is more, the technique identifies key genes and enriched gene ontology pathways, as well as categories related to stem cell differentiation — and specifically toward osteochondral lineages (that is, related to bone and cartilage tissue growth).»
Both pathways appear to be responsible for the differentiation and proliferation of cell type similar to bone mass and osteoblasts (Fig. 6).
Identification of common pathways mediating differentiation of bone marrow - and adipose tissue - derived human mesenchymal stem cells into three mesenchymal lineages.
Unlike highly specialized skin - cell fibroblasts, these cells in the fat have a relatively wide portfolio of differentiation options — becoming fat, bone or muscle as needed.
Differentiation, cell fusion, and nuclear fusion during ex vivo repair of epithelium by human adult stem cells from bone marrow stroma.
Notch signaling enhances osteogenic differentiation while inhibiting adipogenesis in primary human bone marrow stromal cells.
The pool of stem cells in the bone marrow is continuously undergoing a process of self - renewal and differentiation.
Through its various targets, MMP1 promotes not only tumor invasion but also breast cancer colonization to bone by mechanisms that include the release of membrane - bound EGF - like growth factors from tumor cells, leading to activation of EGF receptor signaling and suppression of OPG expression in osteoblasts, which in turn promotes the differentiation and activation of osteoclasts required for bone destruction and enhanced tumor growth in the bone microenvironment (32).
She will study how normal, healthy bone marrow stem cells find a niche and how niche environment regulates stem cell functions such as self - renewal and differentiation.
In humans, germ cell differentiation from ES cells via spontaneous EB formation, and EB formation with recombinant human bone morphogenetic proteins (BMPs) has been reported [5], [6].
J, Hematoxylin and eosin staining of teratoma sections generated from integration - free iPSC lines showing differentiation in three germ layers: goblet cells in gastro - intestinal (GI) tract (endoderm); neural rosettes (ectoderm) and blood vessels, muscle and cartilage / bone (mesoderm).
Another is to monitor the effects of transplanting telomerase - deficient but ex vivo telomere - extended bone marrow into late - generation, TMM - disabled mice, so as to be certain that the niche of such animals (or, by implication, aging humans) will support the homing, engraftment, and initial development and differentiation of such cells; the necessary research is underway now thanks to a SENS Foundation grant to Dr. Zhenyu Ju of the Institute of Laboratory Animal Sciences and Max - Planck - Partner - Group on Stem Cell Aging in the Chinese Academy of Medical Sciences, and research partner of prominent telomere biologist Dr. K. Lenhard Rudolph.
Vitamins B6, B12, and folates (NatureFolate blend) promote proper cell differentiation, and magnesium and calcium are also included to help support bone and hormone function.
Bone marrow - derived mesenchymal stem cells (BMDMSC) are of particular interest in orthopedics, as cells in this lineage are involved in osteogenic differentiation of cells at the site of bone generation and regeneratBone marrow - derived mesenchymal stem cells (BMDMSC) are of particular interest in orthopedics, as cells in this lineage are involved in osteogenic differentiation of cells at the site of bone generation and regeneratbone generation and regeneration.