No significant differences in
bone growth were seen in wild type mice that received rosuvastatin or vehicle (right and second from right).
Not exact matches
They found similar patterns in the left mouse leg to those
seen in osteoarthritis, not only in the knee structures but also in the cartilage that wraps the
bones» ends, suggesting that the injury response
is a further mechanism that triggers altered signaling from the knee joint to the
growth plate.
The benefits for
growth were a welcome surprise, said Pacifici, because the drug normally impairs
bone growth, a side effect
seen in control mice.
One of the central questions
was why Ata — only 15 centimeters tall and thus the size of a 5 - month - old fetus — had
bone development in the
growth plates of its knees that would normally
be seen in a 6 - year - old.
The
growth of these lumps
is triggered by hormonal factors and the
bones underlying them
are pitted with microscopic craters — a feature that can also
be seen in the brow
bones of archaic hominins.»
He notes, however, that other attempts to stimulate
bone growth in mice by manipulating cell signaling proteins have produced denser than normal
bones — and he
's surprised that Helms
's team didn't
see the same.
«While activity during skeletal
growth is significant, we also
saw positive associations between such physical activity and
bone density at all ages.
Foods like meats, fish, eggs, and especially
bone broths (
see below)
are excellent for hair
growth.
So it
is easy to
see the possible challenge of meeting phosphorus needs during times of rapid
bone growth.
Finally, acute changes in blood calcium concentrations do not seem to elicit the secretion of the phosphaturic hormone fibroblast
growth factor 23 (FGF - 23), which
is produced by
bone - forming cells (osteoblasts / osteocytes) in response to increases in phosphorus intake (
see the article on Phosphorus)(2).