Sentences with phrase «bone marrow derived»

Researchers first proposed that this tumor might originate from bone marrow derived cells in 2006.

The Workshop on Inherited Hematopoietic Malignancies will discuss the scientific advances in understanding the pathogenesis of cancer development in individuals and families with germline mutations and predisposition to bone marrow derived malignancies.

Using primary murine bone marrow derived macrophages or human monocyte derived dendritic cells, infected with live or attenuated Chlamydia trachomatis we report that the live organism activates both canonical and non-canonical inflammasomes, but only canonical inflammasomes controlled IL - 1β processing which preceded pyroptosis.

In 2004 she transferred to the NIDCR and heads the Adult Stem Cell Section to study the biology of bone marrow derived stem cells.

Programs that train physicians to perform Adipose and Bone Marrow Derived Stem Cell protocols.

CFU - GM assays using bone marrow derived cells yield very few colonies in repsonse to interleukin 3, but normal colony growth occurs in response to GM - CSF

Bone marrow derived - hematopoietic stem cells (HSCs) were the first stem cells to be identified and to reach the clinic.

At least three types of stem cells were tested for their ability to improve cardiac function: bone marrow derived stem cells (BMSCs), skeletal myoblasts and mesenchymal stem cells (MSCs).

CFU - GM assays using bone marrow derived cells yield very few colonies in repsonse to interleukin 3

The SDF - 1 / CXCR4 axis plays a pivotal role in mobilizing bone marrow derived stem cells and inflammatory cells.

Marina Prewitz (Werner, LG)-- «Decellularised extracellular matrices as instructive microenvironments for bone marrow derived stem cells» (2011)

Formation of mineralized nodules by bone marrow derived cells in a 2D and 3D matrix.

Furthermore, these potentials are expanded by the notion that MSCs can exert functions other than those classically attributed to stem or progenitor cells, including establishment and support of the hematopoietic microenvironment in vivo, as observed for bone marrow derived MSCs.

Regulation of STAT signaling in mouse bone marrow derived dendritic cells by respiratory syncytial virus.

To devise a potential new therapy, the investigators engineered a population of bone marrow derived mesenchymal stem cells loaded with oncolytic herpes simplex virus (oHSV), which specifically kills dividing cancer cells while sparing normal cells.

Not exact matches

Fish bladders, bone marrow and milk protein are just some of the animal - derived agents that might be incorporated in the winemaking process.

In the early 2000s, Johns Hopkins scientists Leo Luznik and Ephraim Fuchs found that giving patients high doses of cyclophosphamide — a drug derived from nitrogen mustard and used to treat blood cancers — three days after bone marrow transplant successfully thwarts acute and chronic GVHD.

Human hematopoietic stem and progenitor cells (HSPCs), derived from bone marrow, have become a primary vehicle for efforts to replace or regenerate cells destroyed by a variety of diseases.

Tufts University biomedical engineers recently published the first report of a promising new way to induce human mesenchymal stem cells (or hMSCs, which are derived from bone marrow) to differentiate into neuron - like cells: treating them with exosomes.

Of the stem cell procedures that are marketed, 61 % of businesses offer fat - derived stem cell interventions and 48 % offer bone - marrow - based treatments.

Hematopoietic stem cells — bone marrow - derived adult stem cells that give rise to the wide variety of specialized blood cells — come in two flavors: the reserve force sits quietly waiting to be called upon while the active arm continually proliferates spawning billions of blood cells every day.

The use of bone marrow - derived stem cells is well established in the treatment of human cancer patients, and veterinary applications for bone marrow - and adipose - derived stem cells are being evaluated.

The cross-disciplinary research team identified a protein derived from bone marrow that has the ability to activate stem cells — the cells that are the most responsive to gene editing.

Now, researchers have for the first time managed to completely replace people's bone - marrow - derived stem cells with those from unrelated donors without causing GvHD.

Scientists were even more stunned in July 2002 when researchers led by stem cell biologist Catherine Verfaillie at the University of Minnesota reported that bone marrow — derived cells they had injected into young embryos contributed to all three embryonic layers, just as embryonic stem cells would do.

A patient's own bone marrow stem cells can form bone and cartilaginous tissue, not the underlying vasculature and nerve compartments; and, embryonic stem cell derived bone may prompt an immune rejection.

Future research Because there are few salivary gland stem cells in the human mouth, the scientists plan to continue using rat salivary glands to refine the process, but eventually hope to use stem cells derived from human bone marrow or umbilical cord blood to regenerate salivary glands for humans.

They then used human stem cells derived from bone marrow that would normally become bone cells to test the effects of the nanoparticles on stem cell proliferation and differentiation.

In this tissue system, we can culture patient - derived megakaryocytes — the bone marrow cells that make platelets — and also endothelial cells, which are found in bone marrow and promote platelet production, to design patient - specific drug administration regimes.»

Tissue macrophages are derived from bone marrow precursors that migrate from the peripheral circulation.

Together these data suggest that the F4 / 80 + cells identified in adipose tissue are CSF - 1 — dependent, bone marrow — derived adipose tissue macrophages.

Our data also suggest that the increased accumulation of macrophages in adipose tissue of the obese is due to an influx of bone marrow — derived precursors into adipose tissue and their subsequent differentiation into mature F4 / 80 - expressing macrophages.

Stimulation of TLR2 / TLR6 triggers profound decreases in ferroportin mRNA and protein expression in bone marrow - derived macrophages, liver and spleen of mice without changing hepcidin expression.

F4 / 80 + cells in adipose tissue are bone marrow — derived.

But, it was known that when HIF - 1 normally activates signals in the body to build new vessels, one of the many types of cells recruited to the site of new vessel growth is a population of stem cells from the bone marrow, which are called bone marrow - derived angiogenic cells.

Many clinical trials have used bone marrow - derived cells, and the benefits here appear to come mostly from the â $ œparacrine» nurse function. A more ambitious approach is to use progenitor - type cells, which may have to come from iPS cells or cardiac stem cells isolated via biopsy - like procedures.

Human bone marrow (BM)- derived progenitor and stem cells administered with an appropriate scaffold represents a potentially exciting alternative treatment option [2], but only if we can discover a safe and rapid strategy to enhance the relatively low inherent osteogenic potential of BM.

Alex Huang and Drew Pardoll, with Elizabeth Jaffee and Hyam Levitsky at Johns Hopkins School of Medicine demonstrate tumor - associated antigen processing and presentation to CD8 + T cell by bone marrow - derived professional antigen presenting cells via «cross-priming.»

Impact of bone marrow - derived mesenchymal stem cells on remodeling the lung injury induced by lipopolysaccharides in mice Mouchira M Mohi El - Din, Laila A Rashed, Mohi A Mahmoud Haridy, Atef Mohamed Khalil, Mohamed A Mohamed Albadry.

Sphingosine -1-phosphate mediates proliferation maintaining the multipotency of human adult bone marrow and adipose tissue - derived stem cells (Retraction of vol 2, pg 199, 2010).

Rac2D57N, a dominant inhibitory Rac2 mutant that inhibits p38 kinase signaling and prevents surface ruffling in bone - marrow - derived macrophages.

Effects of the chemokine stromal cell - derived factor - 1 on the migration and localization of precursor - B acute lymphoblastic leukemia cells within bone marrow stromal layers.

Ovine bone - and marrow - derived progenitor cells and their potential for scaffold - based bone tissue engineering applications in vitro and in vivo.

Skeletal muscle fiber formation, bone marrow stem cell formation, thymus T - cell formation, TNF - a / INF - gamma production by immune system's macrophages (immunosenescence by IGF loss), neuregulin and brain - derived neutrophic factor depend on IGF - 1 acting on brain IGFR receptors.

An example of this type of circuitry analysis includes measuring and interpreting all of these parameters over a time course, following stimulation of mouse bone marrow - derived dendritic cells with bacterial lipopolysaccharides (LPS) endotoxin.

These findings are in agreement with other studies on cell morphology [3, 4] and senescence [5], and the authors hope to advance these studies by separately analyzing subpopulations derived from the same bone marrow sample, and also surveying the grade of cell maturity (surface receptor analysis) and cytoskeleton composition of the cells during cell tracking.

Bone marrow - derived mesenchymal stem cells undergo JCV T - antigen mediated transformation and generate tumors with neuroectodermal characteristics.

Critical role for ERK1 / 2 in bone marrow and fetal liver — derived primary megakaryocyte differentiation, motility, and proplatelet formation.

Blood cells derived from iPS cells also have other obstacles: an inability to engraft into organs or bone marrow and a likelihood of developing tumors.

Sphingosine -1-phosphate mediates proliferation maintaining the multipotency of human adult bone marrow and adipose tissue - derived stem cells.