Sentences with phrase «bone marrow failure»

All of our materials are written in plain language and reviewed by highly respected and recognized medical doctors who are experts in bone marrow failure diseases.

There are many therapies and approaches doctors use to treat bone marrow failure disease patients.

In terms of human health, there was a study in 2001 about patients who had progressive bone marrow failure.

This medication can result in gastrointestinal upset, liver toxicity, skin irritation, or more severe reactions such as bone marrow failure.

Bone marrow failure affects about seven in 100,000 people annually.

Unfortunately she was recently treated for anemia due to bone marrow failure because of over vaccinations.

Bone marrow failure disease patients are at risk for developing iron overload if they have had more than 20 units of packed red blood cells.

«Source of stem cells used for bone marrow failure treatment varies worldwide.»

Ayami Yoshimi, M.D., Ph.D., of the University of Freiburg, Germany, and colleagues examined the use of peripheral blood stem cells and bone marrow as stem cell sources for hematopoietic stem cell transplantation in patients with bone marrow failure worldwide and factors associated with the use of each stem cell source.

The data suggest that this immunosuppression - only approach could benefit patients with DC — and, perhaps, other bone marrow failure syndromes — who are at high risk of poor transplant outcomes because they can not tolerate the toxicity of conventional or even reduced - intensity conditioning.

He then completed his Internal Medicine residency and Hematology / Oncology fellowship training at Cleveland Clinic, in addition to a research fellowship in bone marrow failure syndromes at the same institution.

In further studies, the researchers tested the capacity of ANG to prevent and mitigate radiation - induced bone marrow failure, and in pre-clinical models, they found that survival following radiation exposure was increased after treatment with recombinant ANG protein.

This basic fact makes it difficult for researchers to discern the underlying mechanism of the disease: «It's very difficult to figure out what's wrong, because the bone marrow is nearly empty of these cells,» said Bessler, the director of CHOP's Pediatric and Adult Comprehensive Bone Marrow Failure Center.

While an HSCT can cure the resulting bone marrow failure, outcomes are often poor, likely because of the toxicity associated with conventional conditioning.

Researchers at Dana - Farber / Boston Children's Cancer and Blood Disorders Center report promising outcomes from a clinical trial with patients with a rare form of bone marrow failure who received a hematopoietic stem cell transplant (HSCT) after pre-treatment with immunosuppressive drugs only.

Eighty percent of patients with DC develop bone marrow failure before reaching age 30.

Even though bone marrow failure is a very rare disease, what it showed was that if you have a defective gene for this essential telomerase component, you will never live to be old [sufferers die in their twenties and thirties].

Fanconi anemia afflicts several thousand people worldwide, causing severe bone marrow failure, birth defects, and a form of leukemia.

Using specimens collected annually in patients seen at Dr. Young's bone marrow failure clinic at the NIH Clinical Center, the investigators show that patients can support good blood cell production for many years from only a few stem cell clones, which can contain many unfavorable mutations.

Patients who suffer from Fanconi anemia display bone marrow failure already during childhood and have a risk of developing cancer that is about 1,000 times higher compared to healthy individuals.

Over the years, Dr. Nimer has conducted extensive clinical and basic science research into the treatment and genetic basis of adult leukemia and bone marrow failure states, defining the regulatory mechanisms that control the production of blood cells and exploring ways to improve the treatment of blood based cancers.

«Germline mutations affecting telomere maintenance or DNA repair may, respectively, cause dyskeratosis congenita or Fanconi anaemia, two clinically related bone marrow failure syndromes.

Lethal neonatal bone marrow failure syndrome with multiple congenital abnormalities, including limb defects, due to a constitutional deletion of 3 ′ MECOM

AAMDSIF welcomes support from those interested in supporting our mission to fight bone marrow failure diseases through patient support and research.

Cavalancia met with Amy DeZern, M.D., and Robert Brodsky, M.D., of Hopkins» Center for Bone Marrow Failure Disorders, who took another bone marrow biopsy, and two days later flew out to Seattle to meet the specialists there.

Shwachman - Diamond syndrome (SDS) is a rare, inherited bone marrow failure, characterized by a low number of white blood cells, poor growth due to difficulty absorbing food and, in some cases, skeletal abnormalities.

ATG may be used to treat other bone marrow failure diseases in some cases.

Among 114,217 HSCTs reported by 1,482 transplant teams, 3,282 allogeneic (receipt of stem cells from another individual) HSCTs were performed for bone marrow failure.

Tufts Medical Center and Tufts University scientists have found exciting, new functions of the protein angiogenin (ANG) that play a significant role in the regulation of blood cell formation, important in bone marrow transplantation and recovery from radiation - induced bone marrow failure.

Researchers are studying fludarabine in combination with other medicines for treating bone marrow failure.

With this new understanding of the enzyme, called Inositol trisphosphate 3 - kinase B (ItpkB), scientists are closer to improving therapies for diseases such as bone marrow failure syndrome, anemia, leukemia, lymphoma and immunodeficiencies.

The Aplastic Anemia and MDS International Foundation is the world's leading nonprofit health organization dedicated to patients afflicted with bone marrow failure disease.

With over 30 years of experience as an effective and efficient nonprofit health organization, AAMDSIF offers a range of national partnership opportunities for companies and organizations who care about helping patients and families facing aplastic anemia, MDS, PNH and other bone marrow failure diseases.

Darbepoetin alfa can help improve red blood cell counts in bone marrow failure patients whose natural erythropoietin levels are low.

In DC and other bone marrow failure syndromes, however, the disease itself already weakens or destroys the patient's bone marrow, raising the question of whether a less toxic approach could effectively condition patients for transplant.

For the current study, researchers used next - generation DNA sequencing, a way of rapidly analyzing genes, to examine the genomes of blood samples from more than 400 patients with aplastic anemia, enrolled from centers specializing in the treatment of bone marrow failure.

«Bone marrow failure syndromes are problems of blood and immune cell production,» he added.

People exposed to large doses of radiation face challenges due to bone marrow failure induced by such exposures.

«Our goal is to find out what causes this bone marrow failure during serious infections, and find ways to prevent it,» said Nadia Carlesso, M.D., Ph.D., professor of pediatrics and of medical and molecular genetics at the IU School of Medicine.

«If we can show that ItpkB also keeps human HSCs healthy, this could open avenues to target ItpkB to improve HSC function in bone marrow failure syndromes and immunodeficiencies or to increase the success rates of HSC transplantation therapies for leukemias and lymphomas.»