Basic research has centered on identifying and characterizing hematopoietic stem cells, however, it is still not clear how hematopoietic stem cells actually work, and how they are regulated because of the complexity of
the bone marrow microenvironment.
Contained in spongy bones,
the bone marrow microenvironment and its «niches» support production of platelets and other blood cells.
Rubén Ferrer (Bornhäuser, TUD)-- «Functional analysis of
the bone marrow microenvironment in myelodysplastic syndrome: targeting the disease niche» (2013)
In
the bone marrow microenvironment, CLL cells are protected from spontaneous or drug - induced apoptosis, resulting in resistance to conventional chemotherapy.
Role of B - Cell — Activating Factor in Adhesion and Growth of Human Multiple Myeloma Cells in the Bone Marrow Microenvironment