Application of a polyelectrolyte complex coacervation method to improve seeding efficiency
of bone marrow stromal cells in a 3D culture system.
«No reliable approach is currently available for complete restoration of damaged articular cartilage,» said Dr. Bai - wen Qi, «in this study, CS / PVA gel was combined with
rabbit bone marrow stromal cells (BMSCs) transfected with hTGFβ - 1 and used to repair rabbit articular cartilage defects and the repair effect was evaluated.»
For example, researchers found that
healthy bone marrow stromal cells, which give rise to bone, could strengthen bones and prevent fractures when injected into three children with the bone - weakening disease osteogenesis imperfecta.
Chronic Lymphocytic Leukemia (CLL): CXCR4 expressing neoplastic B - cells migrate
towards bone marrow stromal cells and lymphoid nurse - like cells that secrete high levels of SDF - 1, in a CXCR4 dependent fashion [23].
Specific Induction of Neuronal Cells
from Bone Marrow Stromal Cells and Application for Autologous Transplantation (June, 2004) in Journal of Clinical Investigation.
As a homeostatic chemokine, SDF - 1 is an 8 kDa chemokine peptide with 67 amino acid residues, mainly localized
in bone marrow stromal cells.
In a study published in Nature Communications, the investigators report that hyperglycemic mice (or mice with type 2 diabetes) have a 24-fold higher accumulation of succinate, an intermediate metabolite, in the metabolic pathways of
their bone marrow stromal cells.
The influence of fibrin based hydrogels on the chondrogenic differentiation of human
bone marrow stromal cells.
miRNA - 23a mediates post-transcriptional regulation of CXCL12 in
bone marrow stromal cells.