Sentences with phrase «bound crystal structures»

Not exact matches

Here we report the crystal structure of EF - P bound to the Thermus thermophilus 70S ribosome along with the initiator transfer RNA N - formyl - methionyl - tRNAi (fMet - tRNAifMet) and a short piece of messenger RNA (mRNA) at a resolution of 3.5 angstroms.

The crystal structures of hexameric DnaB and its complex with the helicase binding domain (HBD) of DnaG reveal that within the hexamer the two domains of DnaB pack with strikingly different symmetries to form a distinct two - layered ring structure.

They started by analyzing x-ray crystal structures that show in atomic detail how flu - binding antibodies in people grab on to the three sugar - binding sites on HA's head.

For more than 100 years, researchers have worked under the assumption that smaller crystals melt easily because they have a larger percentage of atoms on the surface, where they're relatively weakly bound to the structure.

Detail of a crystal structure of unbound (right) and signal - sequence bound SRP forms (left, signal sequence depicted in red).

In further tests, he and his colleagues designed a mutated version of the botulism compound, based on the novel crystal structure, in which HA would not bind with the epithelial cell protein E-cadherin.

There were only minor differences in the crystal structures of mutant and wild - type annexin V around the mutation site; however, the mutant showed structural differences elsewhere, including the presence of a calcium binding site in domain III unrelated to the mutation.

Using a crystal structure of a complex protein compound of botulinum neurotoxin, Rongsheng Jin, associate professor of physiology & biophysics at UC Irvine, and collaborators found that these compounds — called clostridial hemagglutinin (HA)-- bind with epithelial cell proteins in the intestines of patients, which initiates a process that disrupts the close intercellular seals so that the complex toxin molecules can slip through the epithelial barrier.

Lei et al. report the crystal structure of this protease bound to a peptido - mimetic inhibitor.

To get a better picture of how this compound interacted with K - Ras, the scientists solved crystal structures of the compound bound to K - Ras.

Coincidentally, co-author Lawrence Shapiro, PhD, at Columbia, was building a crystal structure of cadherin - 11 and is now working with Byers and Brenner to show how the molecule binds to Celebrex and other small molecule drug cadherin - 11 inhibitors.

Further, HB80 inhibits the HA fusogenic conformational changes induced at low pH. The crystal structure of HB36 in complex with 1918 / H1 HA revealed that the actual binding interface is nearly identical to that in the computational design model.

At the beginning of the study, the team struggled to produce a crystal form — needed to obtain data to recreate the high - resolution structure — of the receptor bound with AM6538, a stabilizing a molecule that blocks the receptor's action.

Einsle, Spatzal, and Prof. Dr. Douglas Rees in Pasadena, USA, have obtained a crystal structure that shows how a carbon monoxide molecule (CO) binds to FeMoco.

We report the crystal structure of a human β2 - adrenergic receptor — T4 lysozyme fusion protein bound to the partial inverse agonist carazolol at 2.4 angstrom resolution.

Crystal structures of the ribosome bound to elongation factors provide insights into translocation and decoding.

A protein on the cell surface of P. syringae binds water in a way that mimics the structure of an ice crystal, and this helps start the transformation of cold water into ice.

Subsequently, the research group determined crystal structures of different VERL repeats bound to lysin, the counterpart protein of VERL on abalone sperm.

For PYL receptors whose crystal structures are known, their binding pocket — the part of the protein that binds to ABA — is the same.

Crystal structures of Mtb RNAP bound to rifampin (left), Mtb RNAP bound to an AAP (center), and Mtb RNAP bound to both rifampin and an AAP (right) show that rifampin and the AAP interact with non-overlapping binding sites on Mtb RNAP and, as a result, can bind simultaneously to Mtb RNAP.

«Upon looking closely at the crystal structure of the HasA protein binding heme, we considered the possibility of the HasA protein to bind to a metal complex that has a similar structure as heme» says Associate Professor Osami Shoji, who led the study.

«It took us around four years to discover that phthalocyanine, which is a blue paint used on the surface of the Japanese bullet trains and road signs, could bind competitively to the HasA protein,» adds Ms. Chikako Shirataki, a PhD student in her final year, «crystal structures of metal protein complexes helped us to show that the phthalocyanine - bound HasA protein blocks the receptors on the cell surface of the bacterium and thus, inhibits the uptake of heme.»

«To study this mechanism, we determined, for the first time, the crystal structure of the regulatory domain bound to cGMP, which is the activated form.

Now, scientists at the UNC School of Medicine and UC San Francisco (UCSF) have solved the first high - resolution crystal structure of the dopamine 2 receptor (DRD2) bound to the antipsychotic drug risperidone, yielding a long - awaited tool for drug developers, psychiatrists, and neuroscientists.

Solving the high - resolution crystal structure of DRD2 bound to the commonly prescribed antipsychotic drug risperidone is the first step towards the creation of safer and more effective medications for schizophrenia and related disorders.»

«Breakthrough could lead to better antipsychotic drugs: Research reveals the first - ever crystal structure of the dopamine 2 receptor bound to an antipsychotic drug.»

AlkD (grey) crystal structure bound to DNA containing 3 - deaza -3-methyldeoxyadenosine (light green), from Brandt Eichman.

Crystal structures exist for the G - protein, as well as activated rhodopsin bound to the C - terminal tail of Galpha, but not for the rhodopsin / G - protein complex.

Using X-ray crystallography — a method in which patterns formed by high - powered X-rays shot through a crystal of the molecule reveal its atomic structure — the scientists found that the shape of the binding site in the mZuc protein was consistent with its identity as a nuclease.

Then it took seven more years to produce the first crystal structure of a GPCR bound to a diffusible ligand, the b2 - adrenergic receptor (a receptor for epinephrine), this one published by the Kobilka lab in 2007, during Granier's second and final postdoctoral year.

For all other variants, the TSA was manually placed in the newly created cavity in agreement with structural alignment of the crystal structures from the TSA bound ancestral variants.

Researchers at Whitehead Institute and Memorial Sloan - Kettering Cancer Center have defined and analyzed the crystal structure of a yeast Argonaute protein bound to RNA.

Based on this crystal structure, the active site is localized in a binding pocket formed by at least eight different amino acid residues, including Val32, Lys47, Glu66, Ile69, Leu70, Thr95, Met98, and Asp164 (Fig. 1A).

The crystal structure of OspC, indicating that it is a predominantly α - helical protein with a putative binding pocket for an unidentified ligand (29, 30), has led to speculations on the role of OspC in invasive disease (30).

(iv) Comparison between the binding position of ponatinib found within the crystal structure (yellow) and the binding mode predicted by AutoDock Vina (green).

For the mutations located in the JH1 kinase domain, we took advantage of the recently solved crystal structure of the JAK1 JH1 domain to detail their localization.21 As shown in Figure 1C, D and E, from 13 JH1 - located mutations, 3 (K1026E, Y1035C and S1043I) are located in the activation loop (A-loop), 4 mutations affect the same residue (F958V, F958C, F958S, F958L) in the hinge region of the kinase domain at the entry of the ATP - binding pocket, 3 others (D895H, E897K and T901R) are located at the top of the kinase domain in the loop formed between two antiparallel β - strands (β2 and β3) and one mutation affects the loop formed between the β - strand - 3 (β3) and the αC helix of the JH1 domain (L910Q).

Using molecular modeling (docking) and chemoinformatics analyses, we used the RIPK2 / ponatinib crystal structure and searched in chemical databases for small molecules exerting binding interactions similar to those exerted by ponatinib.

Crystal structures of two novel dye - decolorizing peroxidases reveal a beta - barrel fold with a conserved heme - binding motif.

By analyzing the crystal structure of yeast Argonaute protein bound to RNA, Whitehead researchers created this model of the protein's surface as it is bound to RNA.

CAMBRIDGE, Mass. — Researchers at Whitehead Institute and Memorial Sloan - Kettering Cancer Center have defined and analyzed the crystal structure of a yeast Argonaute protein bound to RNA.

Crystal structure of an ORFan protein (TM1622) from Thermotoga maritima at 1.75 A resolution reveals a fold similar to the Ran - binding protein Mog1p.

Here we report the room temperature crystal structure of the chromophore - binding domains of the Deinococcus radiodurans phytochrome at 2.1 Å resolution.