Not exact matches
With no candidate targets, the team took an objective approach by applying a
peptide phage library to MDSCs, which permitted mass screening for candidate
peptides — short
sequences of amino acids — that
bind to the surface of the MDSCs.
Then they compiled and compared the detailed
sequence — the order of the chemical building blocks — of the
peptides that
bound to each T - cell receptor.
We are developing computational methods to accurately predict the
binding specificity of
peptide recognition domains given the domain
sequence and to predict biologically relevant protein - protein interactions given
binding specificity.
His group has studied
sequence - independent
peptide binding in transporter systems and transcriptional regulators in Bacillus with a focus on the control and execution of the process of cell development leading to the formation of dormant spores.