Sentences with phrase «bound syntaxin»
Scheller found, for instance, that VAMP / synaptobrevin on vesicles clasps plasma membrane - bound syntaxin, and that SNAP - 25 helps them pair up.
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During synaptic vesicle fusion, the soluble N - ethylmaleimide - sensitive factor — attachment protein receptor (SNARE) protein syntaxin - 1 exhibits two conformations that both bind to Munc18 - 1: a «closed» conformation outside the SNARE complex and an «open» conformation in the SNARE complex.
Because the two molecules bound to one another Scheller proposed that VAMP, the synaptic vesicle protein, bridges to syntaxin, the plasma membrane protein — thereby providing a scaffold onto which the molecular machinery that catalyzes membrane fusion can be assembled.
The previous work had shown that VAMP / synaptobrevin, syntaxin, and SNAP - 25 bind to the NSF conglomeration, but not whether they do so alone or together.