Sentences with phrase «bounds of human control»

Not exact matches

It was created by the Mexican Max Ortiz Catalan, who lives in Sweden, the device becomes an extension of the human body through osseointegration, this means that it connects directly to the bone via a titanium implant, and thanks to the neuronal and muscle binding interfaces a robust and intuitive control of the artificial hand is achieved, this way just by thinking about it is possible to move the limb.

These studies will investigate the consequences of ApoF knockdown on cholesterol disposition in an animal model, quantify ApoF levels in human subjects and identify lipoprotein properties that cause ApoF to bind and subsequently inhibit cholesteryl ester transfer protein activity, and investigate the molecular mechanisms controlling ApoF gene expression.

To determine DAXX binding sites in the PCa genome, specifically in the PC3 cell line (derived from bone metastasis of a human PCa case [19]-RRB-, we generated a stable shRNA knockdown (K / D) PC3 cell line and a control shRNA counterpart [Submitted], and performed a ChIP - Seq study.

Susan Amara, USA - «Regulation of transporter function and trafficking by amphetamines, Structure - function relationships in excitatory amino acid transporters (EAATs), Modulation of dopamine transporters (DAT) by GPCRs, Genetics and functional analyses of human trace amine receptors» Tom I. Bonner, USA (Past Core Member)- Genomics, G protein coupled receptors Michel Bouvier, Canada - Molecular Pharmacology of G protein - Coupled Receptors; Molecular mechanisms controlling the selectivity and efficacy of GPCR signalling Thomas Burris, USA - Nuclear Receptor Pharmacology and Drug Discovery William A. Catterall, USA (Past Core Member)- The Molecular Basis of Electrical Excitability Steven Charlton, UK - Molecular Pharmacology and Drug Discovery Moses Chao, USA - Mechanisms of Neurotophin Receptor Signaling Mark Coles, UK - Cellular differentiation, human embryonic stem cells, stromal cells, haematopoietic stem cells, organogenesis, lymphoid microenvironments, develomental immunology Steven L. Colletti, USA Graham L Collingridge, UK Philippe Delerive, France - Metabolic Research (diabetes, obesity, non-alcoholic fatty liver, cardio - vascular diseases, nuclear hormone receptor, GPCRs, kinases) Sir Colin T. Dollery, UK (Founder and Past Core Member) Richard M. Eglen, UK Stephen M. Foord, UK David Gloriam, Denmark - GPCRs, databases, computational drug design, orphan recetpors Gillian Gray, UK Debbie Hay, New Zealand - G protein - coupled receptors, peptide receptors, CGRP, Amylin, Adrenomedullin, Migraine, Diabetes / obesity Allyn C. Howlett, USA Franz Hofmann, Germany - Voltage dependent calcium channels and the positive inotropic effect of beta adrenergic stimulation; cardiovascular function of cGMP protein kinase Yu Huang, Hong Kong - Endothelial and Metabolic Dysfunction, and Novel Biomarkers in Diabetes, Hypertension, Dyslipidemia and Estrogen Deficiency, Endothelium - derived Contracting Factors in the Regulation of Vascular Tone, Adipose Tissue Regulation of Vascular Function in Obesity, Diabetes and Hypertension, Pharmacological Characterization of New Anti-diabetic and Anti-hypertensive Drugs, Hypotensive and antioxidant Actions of Biologically Active Components of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides Adriaan P. IJzerman, The Netherlands - G protein - coupled receptors; allosteric modulation; binding kinetics Michael F Jarvis, USA - Purines and Purinergic Receptors and Voltage-gated ion channel (sodium and calcium) pharmacology Pain mechanisms Research Reproducibility Bong - Kiun Kaang, Korea - G protein - coupled receptors; Glutamate receptors; Neuropsychiatric disorders Eamonn Kelly, Prof, UK - Molecular Pharmacology of G protein - coupled receptors, in particular opioid receptors, regulation of GPCRs by kinasis and arrestins Terry Kenakin, USA - Drug receptor pharmacodynamics, receptor theory Janos Kiss, Hungary - Neurodegenerative disorders, Alzheimer's disease Stefan Knapp, Germany - Rational design of highly selective inhibitors (so call chemical probes) targeting protein kinases as well as protein interaction inhibitors of the bromodomain family Andrew Knight, UK Chris Langmead, Australia - Drug discovery, GPCRs, neuroscience and analytical pharmacology Vincent Laudet, France (Past Core Member)- Evolution of the Nuclear Receptor / Ligand couple Margaret R. MacLean, UK - Serotonin, endothelin, estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) transporters

Arrows indicate NSCs expressing human IgG that does not bind to adjacent MCF7 control cells (A) or areas of NSC - secreted human IgG bound to MCF7 / HER2 target cells (B).

Food science: - Sulfer is one of the most abundant mineral elements in the human body - Sulfer is required for the synthesis of glutathione, one of our endogenous (we make our own) antioxidants — an antioxidant that neutralizes free radicals, helps control blood pressure and inflammation, and helps the liver process toxins - Sulfur is essential for Taurine synthesis — taurine is essential to our Central nervous system and the workings of our cardiovascular system - Sulfur helps bind the amino acid chains that form insulin.

Ropes are an incredible invention to bind, move, and control many of the things around us — including the human body.

It's a pretty decent mode if you think you've really got the hang of the controls because you'll be playing against another human that is bound to be less perfect than the AI in the single - player mode.

This strong ethical and moral responsibility is derivable both from the universally accepted moral principles including the widely accepted golden rule which requires people to treat others as they wish to be treated, and international law including, but not limited to the «no harm» rule which is a widely recognized principle of customary international law whereby a State is duty - bound to prevent, reduce and control the risk of environmental harm to other states and a rule agreed to by all nations in the preamble to the UNFCCC, the «polluter - pays principle» agreed to by almost all nations in the 1992 Rio Declaration, human rights law which requires nations to assure that their citizens enjoy human rights, and many other legal theories including tort law.

This strong ethical and moral responsibility is derivable both from the universally accepted moral principles including the widely accepted golden rule which requires people to treat others as they wish to be treated, and international law including, but not limited to: (a) the «no harm» rule which is a widely recognized principle of customary international law whereby a State is duty - bound to prevent, reduce and control the risk of environmental harm to other states, and a rule agreed to by all nations in the preamble to the UNFCCC, (b) the «polluter - pays principle» agreed to by almost all nations in the 1992 Rio Declaration, (c) human rights law which requires nations to assure that their citizens enjoy human rights, and (d) many other legal theories including tort law.

This impasse raises the prospect that in a year's time — even as the scientific evidence mounts that human impact on the climate system is veering out of control — there will be no internationally agreed legally binding commitments regulating greenhouse gas emissions.

Binding legislation is required in the forms of a new international treaty and national laws to retain meaningful human control over future weapons systems and individual attacks.

The aforementioned type of behaviour falls beyond the bounds of industry controls before the fact; it's human nature kicking in to protect one's perceived turf.