Sentences with phrase «brain and muscle arnt»
Two clock proteins, CLOCK (Circadian locomoter output cycles protein kaput) and BMAL1 (Brain and Muscle Arnt - like1) bind to each other to form a heterodimer complex, which then binds to a DNA sequence called E-box (CACGTG) located in the upper region of clock genes, Per (Period) and Cry (Cryptochrome), present in the genome.
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Altering the function of the clock circadian regulator (CLOCK) and brain and muscle ARNT - like protein 1 (BMAL1), which keep cellular functions synchronized with day - night rhythms, could treat metabolic problems.