Sentences with phrase «brain as a surrogate»

While my initial interest lay in the chemico - physical properties of MR imaging probes, I became increasingly involved in their application to functional MRI (fMRI), a method to map hemodynamic responses in the brain as a surrogate for changes in the underlying neuronal activity.

Objective: The primary objective of the present study was to estimate how large a sample size would be needed for future clinical trials for AD - modifying treatments in Japan using atrophy measures of the brain as a surrogate biomarker.

Not exact matches

Here, we challenged 48 participants (24 controls and 24 marijuana abusers) with methylphenidate (MP), a drug that elevates extracellular dopamine (DA) as a surrogate for probing the reactivity of the brain to DA stimulation.

However, recent evidence indicates that apoE4 expression compromises the blood - brain barrier (as does apoE deficiency).40 Studies of brain histology, neurodegenerative markers, cholinergic activity, and neuronal function in knockout mice have been equivocal.39 Failure of detailed neurocognitive and retinal studies to demonstrate defects in our patient suggests either that the functions of apoE in the brain and eye are not critical or that they can be fulfilled by a surrogate protein.