There is INSUFFICIENT EVIDENCE [2,3,5] abut the effectiveness of creatine in the prevention or treatment of age related muscle loss, bipolar disorder, breathing problems during sleeping (apnea) in infants, chronic obstructive pulmonary disease (COPD), coronary artery disease, dehydration, depression, dermatomyositis, diabetes mellitus type 2, fibromyalgia, heart attack, hereditary motor sensory neuropathy, high cholesterol, HIV / AIDS - related muscle wasting, Huntington's disease, McArdle disease, mitochondrial myopathies, multiple sclerosis, muscle cramps, orthostatic hypotension, osteoarthritis, Parkinson's disease [8], Rett syndrome, polymyositis, rheumatoid arthritis, schizophrenia, skin aging, traumatic
brain injury or vision loss due to gyrate
atrophy of the retina or in improving bone density, memory or cognitive function.
While the relationship between age and
brain atrophy in humans is well documented and could potentially bias a comparison between different age groups,
there is no evidence that this is the case in dogs (a recent study has shown that Labradors in the age groups 1 — 5, 5 — 10 and 10 + have similar cerebellar volumes)[22] or even chimpanzees [25].