The other week the Canadian Sports Concussion Project announced the results from
brain autopsies of four CFL football players.
Not exact matches
When the New York Times printed Einstein's obituary on April 20th, it said that Dr. Harvey performed the
autopsy «with the permission
of the scientist's son,» with another headline that same day proclaiming «Son Asked Study
of Einstein
Brain.»
An
autopsy ruled he died
of a
brain disorder.
A lengthy, well - researched, and powerful article in the Spring 2015 issue
of the NCAA's Champion magazine, not only reports the belief
of many top concussion experts that the media narrative about sports - related concussion trace has been dominated by media reports on the work
of Dr. Ann McKee, which was the centerpiece
of PBS Frontline's League
of Denial, but Dr. McKee's, however belated, mea culpa that «There's no question [that her
autopsies finding evidence
of CTE in the
brains of most
of the former athletes were] a very biased study,» that they involved «a certain level
of... sensationalism», that there were «times when it's overblown» and went «a little too far.»
Because, they asserted, the media, ably aided and abetted by Dr. Ann McKee
of the Department
of Veterans Affairs and Boston University's CTE Center, along with the PBS series, Frontline, had for years been using the results
of autopsies of the
brains of a small, self - selected group
of former athletes to create a «sensationalized state
of fear» about CTE.
What continues to be lost, in my view, in much
of what the media has reported over the last six years about the results
of autopsies conducted by researchers at the Sports Legacy Institute in Boston on the
brains of athletes -
autopsies which show the presence
of the dark splotches
of tau protein which are the tell - tale sign
of CTE - which is that they provide, at most, anecdotal evidence suggesting a possible connection.
We already know about Mom's «baby
brain» and this is quite literal as fetal tissue has been found in Moms»
brains, and can even be detected in
autopsies at the end
of life.
Some
autopsy data shows that infants
of smokers have signs
of established hypoxic - ischemic cellular injury in the
brain and the heart which probably occurred in antenatal life, may have been caused by suboptimal placental function and may have been sub-clinical, but if the baby continues to be in a vulnerable environment exposed to post-natal passive smoking, this could affect autonomic nervous system function and lead to poor temperature control, and poor heart rate and respiration control.
Studies at
autopsy of people who had dementia have detected many
of these so - called microvascular infarcts either by themselves or along with the plaques and tangles more typical
of Alzheimer's in the
brains of people with dementia.
Whereas analyses
of the
brain were once limited to
autopsy samples at the time
of a person's death, advances in an imaging technique known as positron emission tomography (PET) now enable researchers to detect amyloid and tau in the
brains of living people.
One
of the first clues came from
autopsies of people with fragile - X; their
brains had immature synapses, suggesting a missing protein.
When Deter died five years later, an
autopsy revealed that her
brain was riddled with strange tangles and plaques
of a fibrous material containing the remnants
of dead
brain cells.
They also found evidence for blood and lymph vessels in the dura
of autopsied human
brain tissue.
BIRI co-founder Bennet Omalu, the forensic pathologist who discovered physical evidence tying concussions to CTE, assisted in the
autopsy of Seau's
brain, although the results will not be known for weeks.
Check out the
brain of a chronic alcoholic and you'll often find a particular region badly disintegrated;
autopsy someone who was exposed to lots
of organic toxins and you'll see damage in another
brain area.
His
autopsy suggests one troubling explanation: Charles Whitman had a
brain tumor pressing on his amygdala, a region
of the
brain crucial for emotion and behavioral control.
Researchers studied hippocampi from the
autopsied brains of 17 men and 11 women ranging in age from 14 to 79.
An
autopsy can trace the path
of a bullet through a body, or reveal microscopic damage to blood vessels in the
brain, or identify a lethal clog in an artery.
A dye used for more than a century to stain
autopsied brain tissue can prevent the devastating effects
of Huntington's disease in mice, new research shows.
Autopsy and scanning studies indicate that a healthy 69 - year - old like me has been shedding
brain matter at a rate
of 0.5 percent per year for a decade and probably longer.
This anxious behavior mirrored that
of CdLS patients, while
autopsied brain tissue from individuals with CdLS showed symptoms
of disease that matched those
of the experimental mice suggesting that they were a good animal model.
So a team led by autoimmunity researcher and rheumatologist J. Lee Nelson
of the Fred Hutchinson Cancer Research Center in Seattle, Washington, took samples from
autopsied brains of 59 women who died between the ages
of 32 and 101.
During
autopsies, researchers found that their
brains had the lowest amount
of amyloid deposits and contained the most antibodies.
Finally they looked at gene expression in
autopsied brains of individuals with Rett.
In examining
autopsy samples from MS patients, the researchers detected an abundance
of amyloids in
brain lesions and damaged neurons, the hallmarks
of the disease.
Given these insights, amyloids» role in Alzheimer's may be much more complex than researchers thought years ago, when they first discovered the clumps, or plaque, in the
brains of Alzheimer's patients during
autopsy.
Then, they compared the patterns
of gene expression in the resulting neurons with cells taken from
autopsied brains.
He was a veteran professional football player, in his mid-60s when he died, and a paper - thin cross section
of his
brain tissue taken at the
autopsy appears visibly shrunken and atrophied.
Thirteen years ago, McKee was
autopsying Alzheimer's patients when she came across the
brain of an ex-boxer, and then another, and then an ex-football player's
brain.
The medical case reports
of CTE hinged upon
autopsies of their
brains, the subjects having died
of other causes.
According to forensic pathologist Bennet Omalu
of the University
of Pittsburgh, an
autopsy after his death revealed that Waters»
brain had suffered so much damage from football injuries that it resembled that
of an 85 - year - old man with early stage Alzheimer's disease.
The discovery
of brain pathology through
autopsy in former National Football League (NFL) players called chronic traumatic encephalopathy (CTE) has raised substantial concern among players, medical professionals, and the general public about the impact
of repetitive head trauma.
Until last year, both patient and doctor could only guess at what was happening inside the
brain because they had no way — short
of an
autopsy — to see the damage.
Autopsies on humans reveal a similar trend:
brains from older people have a higher content
of oxidised proteins than those from younger people.
The only way to clearly distinguish Alzheimer's from other forms
of mental impairment is an
autopsy, which can reveal telltale
brain lesions.
An
autopsy study showed that Duerson's
brain was riddled with classic signs
of chronic traumatic encephalopathy (CTE), a form
of brain damage that is becoming an increasing concern among athletes in violent contact sports.
The paper by Collinge and his colleagues has sparked a worldwide hunt for similar amyloid pathology in
autopsied brains, and a small study published this January revealed a handful
of related cases.
In Japan, dementia researcher Masahito Yamada at Kanazawa University is making his way through a large number
of such
autopsy specimens and says that the 16
brains he has examined so far show signs
of unusually high levels
of amyloid deposition in cerebral blood vessels.
He and his team
of pathologists were examining the
autopsied brains of four people who had once received injections
of growth hormone derived from human cadavers.
Like other pathologists in countries where people had died
of CJD associated with medical procedures, he rushed to check the centre's archives
of autopsied brains to see if any
of them contained the ominous amyloid deposits.
The
autopsy surgeon, one Thomas S. Harvey, removed Einstein's
brain and later stored portions
of it in a jar at his private practice in Weston, Missouri.
The U.T. Southwestern team, in an effort to get a clearer parallel between the animal and human condition, conducted
autopsies on the
brains of depressed and normal individuals.
This
brain slice from a human
autopsy has taken on vivid color in the hands
of a neuroscientist: green from infection by a lentivirus, red for neurons, blue for the nuclei
of brain cells.
Previous
brain autopsies have shown that patients with TSC, as well as patients with ASD, have reduced numbers
of Purkinje cells, the main type
of neuron that communicates out
of the cerebellum.
Still, when the
brain cells and spinal cord cells
of these babies were examined at
autopsy, there was clear evidence that nusinersen had tricked SMN2 into producing a great deal more
of the full length, motor neuron - protecting protein: two to six times more copies
of SMN's messenger RNA were found in spinal cord samples from nusinersen - treated babies than in
autopsy samples from untreated infants.
Autopsies of people killed by heat stroke often reveal microhemorrhages (tiny strokes) and swelling, and 30 percent
of heat stroke survivors experience permanent damage in
brain function, according to Wilderness Medicine.
He thought about a previous patient, a battered woman whose
autopsy had shown signs
of brain disease.
At
autopsy, we would've used our
brains over our lifetime very differently than our ancestors, and just as a weightlifter has different muscles at
autopsy than a swimmer, probably the analytic portions
of your
brain are enlarged compared to your ancestors while the rote memory portions are not.
Extracting DNA from a museum collection
of jellied
autopsied brains dating back to the 1890s may give researchers a new take on the study mental disorders
«So we went to our
autopsy bank
of human
brain tissue and started looking.»