Sentences with phrase «brain barrier by»

To understand CFD, it is necessary to know that for 5 - MTHF (the active form of folate) to enter the CNS, it needs to be transported across the blood - brain barrier by a carrier known as folate receptor protein alpha or folate receptor 1 (FRA or FR1).

It also reduces the amount of leptin crossing your blood - brain barrier by raising triglycerides.

Methylmercury crosses the protective blood - brain barrier by binding with an essential amino acid that has dedicated carrier proteins for shunting it into brain cells.

To get into the brain they must be shuttled across the blood — brain barrier by specialized transport proteins.

Some bacteria pierce the imposing blood - brain barrier by breaking links in the chain; sneakier ones do it by fooling the guard cells.

Not exact matches

When I look into their eyes I picture a small child's brain stunted by some sort of barrier to critical thinking and any form of research methodology.

The cosmic tide may at one time have seemed to be immobilized, lost in the vast reservoir of living forms; but through the ages the level of consciousness was steadily rising behind the barrier, until finally, by means of the human brain (the most «centro - complex» organism yet achieved to our knowledge in the universe) there has occurred, at a first ending of time, the breaking of the dykes, followed by what is now in progress, the flooding of Thought over the entire surface of the biosphere.

The presence of the S100B protein triggers the release by the body of antibodies which can then leak back into the brain through the damaged blood - brain barrier, where they are thought to attack brain tissue.

The blood - brain barrier, formed by blood vessels, protects the brain from toxins circulating in the body's blood system.

Existing treatments are limited by their ability to cross the blood - brain barrier **, and doses must be kept low to avoid damage to healthy tissue.

The brain is a glaring exception because it is protected by an intricate shield known as the blood - brain barrier.

An experimental drug in early development for aggressive brain tumors can cross the blood - brain tumor barrier, kill tumor cells and block the growth of tumor blood vessels, according to a study led by researchers at the Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James).

The word barrier sounds formidable, but scientists didn't even know the blood - brain barrier existed until they discovered it by accident just over a century ago.

These include the amount of lifetime exposure and individual differences in biochemistry that affect whether BMAA is absorbed by the gut, destroyed by the liver, or allowed to cross the blood - brain barrier.

It is, however, clear that cocaine is taken up rapidly and continuously by zebrafish larvae, which at this early stage have not yet a fully developed blood - brain barrier.

The transparency made it possible for them to identify peripheral nerves — tiny bundles of nerves that are poorly understood — and to map the spread of viruses across the mouse's blood - brain barrier, which they did by marking the virus with a fluorescent agent, injecting it into the mouse's tail and watching it spread into the brain.

Sydenham chorea was like rheumatic fever of the brain, thought to occur when rheumatic fever progresses and strep antibodies (emboldened by fever) breaches the blood - brain barrier (BBB), the tight wall of endothelial cells ordinarily there to protect the brain from the outside world.

The researchers began their work by considering how they might breach the blood - brain barrier.

The «blood - brain barrier» is also at the centre of a potential puzzle raised by research such as today's research: how can the immune system have an effect in the brain when many inflammatory markers and antibodies can not penetrate this barrier?

Scientists are hopeful that ultimately these cells could be transformed in the laboratory to yield specific cell types needed for a particular treatment, or to cross the «blood - brain barrier» by expressing specific therapeutic agents that are released directly into the brain.

The brain is protected by a barrier of cells that tightly regulates the transport of substances into this organ in order to prevent infection.

In green, capillaries that form part of the blood - brain barrier; in red, molecules attached to the shuttle patented by IRB Barcelona have managed to cross the barrier and reach the brain (black background).

They believe the detrimental effects are caused by tiny pollution particles that enter the brain through the nose, lungs and gastrointestinal tract, and these particles damage all barriers and travel everywhere in the body through the circulatory system.

Affecting the central nervous system, it causes neonatal meningitis by multiplying in immune cells, such as macrophages, and then disseminating into the bloodstream to subsequently invade the blood - brain barrier.

Acetaminophen can cross the placental barrier, Ritz noted, and it is plausible that acetaminophen may interrupt fetal brain development by interfering with maternal hormones or through neurotoxicity, such as the induction of oxidative stress, which can cause the death of neurons.

Once the nanoparticles squeezed through the barrier and the mouse was exposed to a weak magnetic field, the critter's brain responded by firing electrical signals.

Cytokines can reach the brain several ways: directly through the blood - brain barrier or indirectly by binding to nerve fibers elsewhere, which send signals to the brain to produce the inflammation molecules.

• In our article on disrupting the blood - brain barrier, the area stimulated by ultrasound measured 1 by 5 centimetres (22 October, p 14).

• In our article on disrupting the blood - brain barrier, the area stimulated by ultrasound measured 1 by 5 centimetres (22...

«The central nervous system is protected from pathogens by a highly selective barrier that keeps the circulatory system physically separated from the brain,» lead author Shogo Tanabe explains.

Now, to enable widespread gene delivery throughout the central and peripheral nervous systems, Caltech researchers have developed two new variants of a vector based on an adeno - associated virus (AAV): one that can efficiently ferry genetic cargo past the blood - brain barrier; and another that is efficiently picked up by peripheral neurons residing outside the brain and spinal cord, such as those that sense pain and regulate heart rate, respiration, and digestion.

This barrier works to protect the brain from toxins by allowing only small molecules to pass through.

Instead, the brain is protected by the blood - brain barrier, a highly selective filtration system which keeps out invaders and the army of patrolling white blood cells.

Because the blood - brain barrier made it impossible for the T cells to affect the brain from the inside, Kipnis wondered whether they were maximizing their long - distance influence by getting as close as they could to the brain.

A team led by principal investigator Donald M. O'Rourke, MD, an associate professor of Neurosurgery at Penn, and Marcela Maus, MD, PhD, showed that CART - EGFRvIII cells had an acceptable safety profile, crossed the blood - brain barrier, infiltrated the tumor, and prompted an immune response, resulting in reduction of the EGFRvIII tumor antigen in GBM cells.

Researchers in the U.S. and the U.K. investigated how three major meningitis - producing bacteria avoid being blocked by barrier cells in the brain.

Kipnis was fascinated by the discovery because he knew that T cells can not get past the blood - brain barrier.

Consequently, these grafts may be used to deliver very large drugs, including proteins, which would otherwise be blocked by the blood - brain barrier.

By inducing cells that line the capillaries to keep a tight seal, astrocytes maintain the blood - brain barrier, which protects the brain from many circulating molecules.

By sopping up other amino acids from the blood, however, insulin reduces the tryptophan's competition; the transport system is no longer tied up and more tryptophan can cross the blood — brain barrier.

In the current study, being published in the journal Science Translational Medicine, the international interdisciplinary research team demonstrates that the transport of molecules across the blood - brain barrier can be modulated by gut microbes — which therefore play an important role in the protection of the brain.

The investigators reached this conclusion by comparing the integrity and development of the blood - brain barrier between two groups of mice: the first group was raised in an environment where they were exposed to normal bacteria, and the second (called germ - free mice) was kept in a sterile environment without any bacteria.

A new study in mice, conducted by researchers at Sweden's Karolinska Institutet together with colleagues in Singapore and the United States, shows that our natural gut - residing microbes can influence the integrity of the blood - brain barrier, which protects the brain from harmful substances in the blood.

To prevent collateral damage to precious nerve cells during immune skirmishes, the brain and spinal cord are tightly sealed off from the rest of the body by the blood - brain barrier.

Our brains are surrounded by a blood brain barrier which protects the brain from harmful substances that could enter it via the bloodstream.

«Normally, the brain is protected by the so - called blood - brain barrier (BBB), but in the case of infections and inflammation, new research has shown that the brain can be affected on account of a more permeable BBB.»

To address this concern, de Leeuw recently published a study in the journal Behavior Research Methods investigating whether one specific issue among brain researchers — the potential delays in response introduced by the use of online technology — represents a significant barrier to conducting research online.

Genentech scientists led by Mark Dennis designed an antibody with two arms — one that binds to BACE1 and inhibits its activity and one that binds to the transferrin receptor and tricks endothelial cells into transporting the antibody across the blood - brain barrier.

There is a caveat, however: The enzyme Hunter patients now receive does not cross the blood - brain barrier, the tight network of cells that protects the brain from pathogens, and the livermade enzyme produced by the gene edit may not either.

Jansen is among those who think that a compromised network of blood vessels in the brain triggers Alzheimer's by allowing toxins to cross the blood - brain barrier, potentially leading to damage to neurons and inflammation.