Sentences with phrase «brain cancer cells»
She demonstrated that early experience leads to lasting changes in the molecular structure of the brain and discovered a gene involved in the spread of brain cancer cells into healthy brain tissue.
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The hand - held Raman spectroscopy probe enables surgeons, for the first time, to accurately detect virtually all invasive brain cancer cells in real time during surgery.
By tweaking the chemical properties of the particles, the team was able to find a composition that decreased GFP's glow in the human brain cancer cells by 91 percent.
The groundbreaking study identified a protein, known as cadherin - 22, as a potential factor in cancer metastasis, or spread, and showed that hindering it decreased the adhesion and invasion rate of breast and brain cancer cells by up to 90 per cent.
In 2002, they discovered that the gene alteration makes brain cancer cells more responsive to anticancer drugs known as alkylating agents.
«We showed that PPF decreased glioblastoma cell expression of TROY, inhibited glioma cell invasion, and made brain cancer cells more vulnerable to TMZ and radiation,» said Dr. Nhan Tran, Associate Professor and head of TGen's Central Nervous System Tumor Research Lab.
However, this is the first time these biodegradable nanoparticles have effectively killed brain cancer cells and extended survival in animals.
«Often it is impossible to visually distinguish cancer from normal brain, so invasive brain cancer cells frequently remain after surgery, leading to cancer recurrence and a worse prognosis,» says Dr. Kevin Petrecca, Chief of Neurosurgery and brain cancer researcher at The Neuro, and co-senior author of the study published today in Science Translational Medicine.
Cancer Center investigators uncover a genetic alteration that inhibits how brain cancer cells respond to chemotherapy.
This capability allowed the researchers to maneuver the nanospears in a lab dish to modify brain cancer cells so that they expressed a green fluorescent protein.
This article appears in print under the headline «Zika virus can be used to attack brain cancer cells»
A team headed by neurosurgeon John Yu has discovered that neural stem cells have the ability to track metastasized brain cancer cells as they migrate from the tumor.
Two recently discovered genetic differences between brain cancer cells and normal tissue cells — an altered gene and a snippet of noncoding genetic material — could offer clues to tumor behavior and potential new targets for therapy, Johns Hopkins scientists report.
«Researchers uncover more genetic links to brain cancer cell growth.»
Brain cancer cells often cluster around neurons, a phenomenon called «perineuronal satellitosis,» and the extent of innervation in tumors has long been recognized as predictive of patient outcome.
In another experiment, treating human brain cancer cells containing FGFR3 - TACC3 with mitochondrial inhibitors interrupted the production of energy inside cancer cells and significantly slowed tumor growth.
Olson, also a pediatric oncologist at Seattle Children's Hospital, and his team developed Tumor Paint by re-engineering scorpion venom (chlorotoxin), which naturally targets brain cancer cells.
As we'd been working hard optimising conditions to grow normal neural stem cells in the lab, the immediate question for me was could we grow brain cancer cells in the same way.
The goal was to deepen the knowledge about the pharmacological and cytotoxic effects of the drug Temodex in vitro in different human brain cancer cell lines.
Directly injected viral vector, Toca 511, is designed to spread through brain cancer cells and kill them while leaving healthy cells unharmed
Working together, Johns Hopkins biomedical engineers and neurosurgeons report that they have created tiny, biodegradable «nanoparticles» able to carry DNA to brain cancer cells in mice.
«We have identified a code of «molecular switches» that control a very aggressive subpopulation of brain cancer cells, so - called glioblastoma stem cells,» says Mario Suvà, MD, PhD, of the MGH Department of Pathology and Center for Cancer Research, co-lead author of the Cell article.
Adam Williamson, Ph.D., a CRI postdoctoral fellow at the University of California, San Francisco, wants to understand how brain cancer cells that have died can stick around and promote inflammation and cell death, which can cause irreversible damage.
The result was a highly selective drug they named SBI - 0206965, which successfully killed a number of cancer cell types, including human and mouse lung cancer cells and human brain cancer cells, some of which were previously shown to be particularly reliant on cellular recycling.
«We also identified a way to de-stabilize the SOX9 protein by treating the brain cancer cells with small molecular drugs, which made them less resistant to chemotherapy again,» says Olle Sangfelt, the other principal investigator of the study and research group leader at Karolinska Institutet.
«We have shown that when FBW7 is functionally inactivated this leads to a block of degradation of the stem cell protein SOX9 which becomes more stable in the brain cancer cells,» said first author Aldwin Suryo Rahmanto at the department of Cell and Molecular Biology.
As in their mouse study, the siRNA was more effective — in this case at causing cell death — in the brain cancer cells (up to 97 percent effective) than in the non-cancerous cells (0 to 27 percent, depending on nanoparticle type).
In a related study, published online on March 27 in the same journal, Green's group also showed that a different particle formulation could effectively carry and deliver so - called siRNAs to brain cancer cells.
«In our experiments, our nanoparticles successfully delivered a test gene to brain cancer cells in mice, where it was then turned on,» says Jordan Green, Ph.D., an assistant professor of biomedical engineering and neurosurgery at the Johns Hopkins University School of Medicine.
They then added these particles to brain cancer cells and to non-cancerous brain cells growing in the laboratory.
Previous research on mice found that nanoparticles carrying genes can be taken up by brain cancer cells, and the genes can then be turned on.
Studying breast and brain cancer cells in a hypoxia incubator, Uniacke and his team discovered that cadherin - 22 is involved in this process to enable the spread of cancer cells.
When they found a good candidate that could deliver genes to rat brain cancer cells, they filled the nanoparticles with DNA encoding an enzyme, herpes simplex virus type 1 thymidine kinase (HSVtk), which turns a compound with little effect into a potent therapy that kills brain cancer cells.
This brings up the possibility that brain cancer cells that originate from glial cells can be forced into a mature state and thus unable to divide.
Because the stem cells generate the brain cancer cells, killing off the stem cells might prevent tumors from recurring.
A new study shows that the virus, known for killing cells in the brains of developing fetuses, could be redirected to destroy the kind of brain cancer cells that are most likely to be resistant to treatment.
«Brain cancer cells are very good at evading the host immune system, because they do not express specific targets that can be recognized by immune cells,» said Liau, professor and vice chair of neurosurgery.
High doses of vitamin C can weaken lung and brain cancer cells.