Sentences with phrase «brain cells engineered»

In tests on human brain cells engineered to make more normal prions than usual, Hooper found that the cells secreted far less amyloid beta peptide than they would ordinarily.

Not exact matches

His work indicates that this cell surface marker could serve as a target for a novel brain cancer vaccine or T - cell therapies engineered to recognize and kill tumors carrying that neoantigen.

When injected into mice engineered with a tau mutation that makes the protein clump abnormally in brain cells, triggering memory and motor problems, the antibodies reduced the clumping and improved the animals» behavior.

However, some mice experienced dangerous levels of brain swelling, a side effect of the immune response triggered by the engineered cells, the researchers said, adding that extreme caution will be needed to introduce the approach in human clinical trials.

That summer, he found a way to build engineered neural networks using brain cells collected from rodents.

Chemogenetics builds on optogenetics, which involves genetically engineering brain cells so that they fire in the presence of light.

A technique that involves genetically engineering brain cells so that they fire in the presence of certain drugs has been used to treat epilepsy in rats, and it could soon be tested in humans.

The tremors and other movement impairments of Parkinson's are triggered by the death of dopamine - producing cells in the brain, so the investigators used flies that had been genetically engineered to have their dopamine cells die off as they age.

Some researchers have been trying an alternative route: engineering gene - delivery vehicles such as viruses to transfer neurotrophic - factor genes directly into brain cells.

Working together, Johns Hopkins biomedical engineers and neurosurgeons report that they have created tiny, biodegradable «nanoparticles» able to carry DNA to brain cancer cells in mice.

«In our experiments, our nanoparticles successfully delivered a test gene to brain cancer cells in mice, where it was then turned on,» says Jordan Green, Ph.D., an assistant professor of biomedical engineering and neurosurgery at the Johns Hopkins University School of Medicine.

To visualize the brain locations of these patches, they engineered the dati lacking mutant cells to express a green fluorescent protein.

In the current paper, Pedersen and his colleagues used genetic engineering techniques to selectively activate particular groups of cells in the brain.

To test the possibility, Deisseroth engineers an animal with light - sensitive proteins in the brain cells lying along the suspected pathway.

Now head of her own lab at Stanford, Heilshorn engineers proteins to aid neural stem cells in healing injured brains and spines.

Emotiv solved this brain — computer interface problem with the help of a multidisciplinary team that included neuroscientists, who understood the brain at a systems level (rather than individual cells), and computer engineers with a knack for machine learning and pattern recognition.

«A few years ago we recognized that stem cells could be used to continuously deliver these therapeutic toxins to tumors in the brain, but first we needed to genetically engineer stem cells that could resist being killed themselves by the toxins,» he said.

When engineered to glow green and injected into mice, these studies revealed glowing cells in unexpected organs such as the brain, heart and liver.

A technique that involves genetically engineering brain cells so that they fire in the presence of certain drugs has been used to treat an epilepsy - like condition in rats, and it could soon be trialled in humans.

Using a technique called optogenetics, they were able to turn on genetically engineered brain cells in rats using a blue light delivered directly to those cells via an optic fiber.

Plasma from old mice didn't have a strong effect when injected into young mice genetically engineered to lack VCAM1 in certain blood - brain barrier cells.

A biomaterials engineer is working on a way to fix the cells in our brain that don't heal on their own.

Far from a way to engineer smarter rodents, the work suggests that human brain evolution involved a major upgrade to cells called astrocytes.

To find out, Leifer and his collaborators genetically engineered the one - millimeter - long nematode worm to make particular cells in its body sensitive to light, a technique called optogenetics, developed in recent years by Stanford University psychiatrist and bioengineer Karl Deisseroth [see Deisseroth's «Controlling the Brain with Light,» Scientific American, November 2010].

For instance, autonomous vehicles could eventually prevent tens of thousands of road deaths; optogenetics — using genetic engineering and light to manipulate brain cell activity — could help cure or manage debilitating neurological diseases; and materials like graphene could ensure more people than ever have access to cheap clean water.

The safe use of a stem - cell - based therapy against brain metastasis would require preventing the engineered cells from persisting within the brain, where they could affect normal tissue and possibly give rise to new tumors.

We still have our flesh and blood cells, but we soup them up with nanotech brain chips, genetic engineering and these sorts of things.

The brain organoid, engineered from adult human skin cells, is the most complete human brain model yet developed, said Rene Anand, professor of biological chemistry and pharmacology at Ohio State.

To get to the bottom of this question, researchers in the Perelman School of Medicine at the University of Pennsylvania engineered mice in which the damage caused by a mutant human TDP - 43 protein could be reversed by one type of brain immune cell.

Dr. Sonntag studies this concept on the molecular and cellular level using a translational research approach that integrates the analysis of human material, such as postmortem brains, primary cell systems, and neural cell populations generated from patients» - or healthy individuals» - derived induced pluripotent stem cells (iPSC), or induced neurons (iNs), in combination with molecular, biochemistry, and lentivirus - mediated gene - engineering technologies.

In a world - wide first, Chinese scientists cloned two monkeys by transplanting donor cells into eggs, they said on Wednesday, a feat that could lead to genetically engineered primates for drug testing, gene editing and brain research.

Los Angeles, CA (Scicasts)-- Investigators at Cedars - Sinai are exploring a new way to treat amyotrophic lateral sclerosis (ALS) by transplanting specially engineered neural cells into the brain.

Non-virally engineered human adipose mesenchymal stem cells produce BMP4, target brain tumors, and extend survival.

But scientists can engineer cells in an animal's brain to make them.

The team used genetically engineered mice to study the effects of different human apoE variants on the maturation of neural stem cells or progenitor cells, from which new neurons develop in the adult brain.

«I thought that if our team could find a way to simplify and better control that approach, we might be able to improve the way we engineer human brain cells in the lab.»

The devices include ultra-miniaturized light - emitting diodes, or LEDs, which allowed the researchers to stimulate the mice's brain cells, some of which had been genetically engineered to respond to light.

While it would normally take several months to produce brain cells, Gan and her team can now engineer large quantities of them within 1 or 2 weeks, and have functionally active neurons within 1 month.

New approaches to microscopy, precision laser ablation of individual cells and capillaries, and genetic engineering of model organisms are opening new vistas for exploring the brain and how it works.

«The problem is that brain cells from actual people don't survive well in a dish, so we need to engineer human cells in the lab,» explained Gan, senior investigator at the Gladstone Institutes.

This meant that every engineered brain cell was now identical.

Distilling the most radical accomplishments being made in labs worldwide, including gene therapy, genetic engineering, stem cell research, life extension, brain - computer interfaces, and cloning, More Than Human offers an exciting tour of the impact biotechnology will have on our lives.