Sentences with phrase «brain cells targeted»

Further study is needed to translate these findings to humans as the researchers still have to determine if the same group of brain cells they targeted in rats also influences alcohol addiction in humans.

The brain cells targeted are called «glial» cells - not «neurons», which are the brain cells that send messages to each other.

Not exact matches

Unlike some of the promising treatments that have failed in 2017 that deal with the so - called «amyloid hypothesis» (the treatments target amyloid beta deposits in the brain that accumulate in people with Alzheimer's disease), approaches that try to prevent nerve cells from dying wouldn't have any impact on that buildup.

Chemotherapy works by killing cancer cells by targeting fast - dividing cells, and in most cases, kills off some healthy cells along the way, including nerve cells in the brain.

His work indicates that this cell surface marker could serve as a target for a novel brain cancer vaccine or T - cell therapies engineered to recognize and kill tumors carrying that neoantigen.

Researchers hope the organoids will be better than lab animals or cells growing in culture at revealing how the human brain develops, both normally and when things go awry, and identify potential therapeutic or genome - editing targets.

The Zika virus can cross the blood - brain barrier, and could target cancer cells, sparing normal adult brain tissue and opening a potential new way to attack the disease.

If we can learn lessons from Zika's ability to cross the blood - brain barrier and target brain stem cells selectively, we could be holding the key to future treatments.»

Still, researchers are intrigued by the possibility that cells may use these clearance mechanisms to propagate misfolded proteins throughout the brain — in which case targeting the mechanisms could conceivably slow disease progression.

This early stage research will explore how the virus targets stem cells and provide the starting point to develop new treatments that seek out the tumour and spare the surrounding healthy brain tissue.

Yang said the study not only indicated which genes are affected by traumatic brain injury and linked to serious disease, but also might point to the genes that govern metabolism, cell communication and inflammation — which might make them the best targets for new treatments for brain disorders.

«Few drugs have the capacity to cross the tumor blood - brain barrier and specifically target tumor cells,» says principal investigator Balveen Kaur, PhD, associate professor of neurological surgery and chief of the Dardinger Laboratory of Neurosciences at the OSUCCC — James.

But scientists were stumped on how to best integrate the cell grafts into the brain's complex circuitry, where they would be more targeted and do the most good.

Specifically, it targets the cochlea, a snail - like structure in the inner ear where sensitive cells convey sound to the brain.

These molecules could be attached to the quantum dots in order to target specific brain cells and could be administered intravenously.

Nagoya University - led research team shows in mice the potential of a special immune cell that targets a key protein in tumor growth that helps stop brain cancer.

Transcranial magnetic stimulation can stimulate brain cells from outside the head, but is not highly targeted and so affects large areas of the brain at once.

A preclinical study shows that an experimental nanotechnology drug called SapC - DOPS crosses the tumor blood - brain barrier, targets brain - tumor cells and retards growth of tumor blood vessels.

They cross the blood - brain / blood - tumor barrier, and accumulate within brain tumor sites, where they target oncogenes, regulate cell growth and differentiation, reduce tumor burden and prolong survival in our mouse models.»

Gene switches have been identified that work in specific brain areas, potentially enabling targeted treatment of unhealthy cells.

«Only by understanding the complexities of what happens in specific cell - types found in specific areas of the brain during this disease can targeted treatments for Parkinson's disease be produced.»

Neurons that turn off brain circuits do so by decreasing electrical activity to target nerve cells.

The virus appears to invade the brain by infecting a type of glial cell called olfactory ensheathing cells (OECs), which nourish smell - sensing neurons and guide them from the olfactory bulb to their targets in the nervous system.

Using the JEDI technology, Mount Sinai researchers uncovered evidence that immune cells can find cells in the brain expressing their target antigen, even in non-infected states, which provides evidence of an immune surveillance pathway within the body's central nervous system.

«If they are improperly positioned, they will form the wrong connections, which can lead to signals being sent to the wrong target cells in the brain.»

The findings reveal that NG2 glia represent a promising target for neuronal cell replacement strategies to treat traumatic brain injury.

«The genes which these miRNAs regulate also had increased levels, indicating that these gene expression, indicating that these gene products were likely targeted for storage and for possible future use within the brain cell, rather than for destruction.

Psychoactive drugs, targeting general brain regions and cell types, were too broad as well.

He targeted ChR2 to the sleep cells and then, using optical fiber, delivered light directly to the mice's brains.

Would all this carefully targeted weaponry that destroys cancer cells without inflicting collateral damage on normal tissue work on cancers outside the brain?

A molecule in cells that shuts down the expression of genes might be a promising target for new drugs designed to treat the most frequent and lethal form of brain cancer, according to a new study by researchers at The Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James).

«We are developing a fetal brain stem cell line to identify other fetal brain sugars that may be targets of Zika,» he adds.

Based on previous studies, researchers have hypothesized that recreational noise exposure might damage the circuitry between sensory hair cells in the inner ear and their auditory nerve targets that deliver information to the brain.

The study focused on the serotonin transporter, a molecule that regulates the amount of serotonin signaling between brain cells and is a major target for treatment of depression and mood disorders.

Today the brain's serotonin system is already a known target for the treatment of depression, and according to researchers it should be possible to use time signals in pharmaceutical development based on stem cells.

TRPV1 channels are widely distributed throughout the human brain, so another major challenge is figuring out how to deliver stimulation only to the cells researchers want to target, he adds.

The study is a solid confirmation of previous papers that showed B2M's important role in aging and memory, says biologist Irina Conboy of the University of California, Berkeley, who recently published a scientific paper showing that targeting a separate molecule can lower levels of B2M and restore brain cell formation.

Implanted devices send targeted electrical stimulation to the nervous system to interfere with abnormal brain activity, and it is commonly assumed that neurons are the only important brain cells that need to be stimulated by these devices.

These investigations take advantage of white blood cells, monocytes, and macrophages that can target an inflammation site, including inside the brain.

His work suggests that deep - brain stimulation — whether electrical or optical — may be most effective when it targets not the neurons themselves but the connections between cells, thereby affecting the flow of activity between brain regions.

«If you're looking for very specific molecular targets or pathways in the brain, and how drugs might act on them, the difference between human cells and mouse cells is significant.»

The researchers took immune cells isolated from paralyzed mice that specifically target and harm the brain and spinal cord, and treated them with either CBD or THC.

Professor Geoff Pilkington, study co-author and Head of the Brain Tumour Research Centre, said: «Although this work is still at an early stage, we have demonstrated key elements that are associated with tumour cell binding to blood vessels and this may provide a target for future drug development to prevent the development of secondary tumours in the bBrain Tumour Research Centre, said: «Although this work is still at an early stage, we have demonstrated key elements that are associated with tumour cell binding to blood vessels and this may provide a target for future drug development to prevent the development of secondary tumours in the brainbrain.

Gene switches have been identified that work in very specific brain areas, potentially enabling light to target unhealthy cells without disrupting healthy ones.

Whereas traditional MS medications target the immune system's T - cells, ocrelizumab focuses on destroying the system's B - cells, which fuel the brain inflammation that causes the disease to worsen.

C1q also plays a positive role in the brain by clearing out dead cells and helping target harmful materials, so learning how to manipulate its presence to prevent debilitating synapse loss while maintaining its normal functions will require further research.

This process allows specialized Pac - Man — like brain cells called microglia to engulf the targeted synapses, paving the way for more precise brain wiring.

A better understanding of aberrant brain receptor signaling that leads to nerve cell dysfunction could reveal a target for therapy, according to the authors.

Cells in the targeted brain regions fired when researchers asked subjects about their own views; they would also activate if such questions were followed by queries about the character with whom the volunteer most identified.

Because of the work of several other collaborators, Haughey says, his team knew that some sort of inflammation - promoting molecule was released from brain and targeted to the liver after brain injury to send immune system cells to the damaged area, but the identity of this go - between had been elusive for years.