Scientists in the laboratory of C. Ronald Kahn, M.D., head of Joslin's Integrative Physiology and Metabolism research section, found that
brain cholesterol synthesis, the only source of cholesterol for the brain, drops in several mouse models of diabetes.
Additionally, the Joslin work showed a connection between the decrease in
brain cholesterol synthesis and appetite.
Not exact matches
In fact,
cholesterol is vital for healthy
brain development, sexual health and
synthesis of Vitamin D (see related articles - Dr. Mercola, Food renegade, Our Nourishing Roots).
«But nobody had ever suspected that insulin and diabetes would play an important role in
cholesterol synthesis in the
brain.»
Kahn and his team suspected that reduced
cholesterol synthesis interferes with
brain synapses.
Additionally, chromium has been shown to help promote efficient
brain function by aiding in
cholesterol synthesis.
Any pharmaceutically - induced disruption in endogenous
synthesis of
cholesterol — especially when combined with long - standing, population - wide recommendations to limit dietary intake — would starve the struggling
brain of this absolutely critical nutrient.
They also inhibit the
cholesterol - producing enzyme HMG - CoA reductase in the liver, which lowers LDL, and in other cells (including the
brain) which can produce both benefits and harms (for example, this enzyme is also needed to make vitamin K2, which is important for sulfatide
synthesis in the
brain and hence cognition).