Two papers in this new thematic series of the journal shed light on the «female protective effect» — the theory that there is a mechanism protecting the developing female
brain from autism.
Not exact matches
Recently, researchers
from Harvard and Mt Sinai found that both environmental chemicals and environmental stress can disrupt the development of a fetus»
brain and negatively impact the baby's long - term health, even increasing the risk of
autism spectrum disorders.
The latest round of START - UP participants was announced Monday in Buffalo, with companies that range
from software developers for the legal profession and a biotech firm working on genetic markers for
autism to a developer of
brain injury drugs.
Tiny balls of
brain tissue made
from donated stem cells
from children with
autism or a condition that makes them hyper - sociable show intriguing differences
Using data
from National Database for
Autism Research (NDAR), lead author Kristina Denisova, PhD, Assistant Professor of Psychiatry at CUMC and Fellow at the Sackler Institute, studied 71 high and low risk infants who underwent two functional Magnetic Resonance imaging
brain scans either at 1 - 2 months or at 9 - 10 months: one during a resting period of sleep and a second while native language was presented to the infants.
Recent research suggests that too many connections in the
brain could be at least partially responsible for the symptoms of
autism,
from communication deficits to unusual talents.
The team says it is not clear whether the unwanted connections are indispensable stepping stones or routine «overshoots» but the discovery may throw new light on diseases thought to result
from misconnections during
brain development, such as
autism.
Scientists copy nature's most complex organ in the hope of solving the mysteries of
brain disorders,
from autism to Alzheimer's
Researchers at Weill Cornell Medical College have uncovered a mechanism that guides the exquisite wiring of neural circuits in a developing
brain — gaining unprecedented insight into the faulty circuits that may lead to
brain disorders ranging
from autism to mental retardation.
The question that carried him
from vision research to
autism had to do with what happens after light hits the human retina: How are the incoming signals transformed into data that are ultimately processed as images in the
brain?
To conduct the study, scientists took dental pulp cells
from donated baby teeth of three children with diagnoses of non-syndromic
autism (part of the on - going «Tooth Fairy Project») and reprogrammed the cells to become either neurons or astrocytes, a type of glia or support cell abundantly found in the
brain.
A freezer failure at the world's largest repository of human
brains has led to the loss of 147 of them, including a rare collection of 53
brains from donors with
autism.
The same conflict that gives rise to
autism and schizophrenia may be at work in all of us, nudging us one way or another on the spectrum
from father -
brain to mother -
brain.
Next, the researchers confirmed that
brain tissue
from donors who had
autism indeed contains low amounts of the RORA protein and aromatase.
The fact that the accelerated rate of
brain growth occurs in an infant's first year suggests that
autism springs
from a genetic or prenatal biological cause, not
from later environmental factors such as vaccinations, adverse allergic reactions, or exposure to toxins.
Interestingly, the authors noted that since the study showed that microbiota in the gut can influence the
brain, it «adds to evidence suggesting that the intestinal microbiota may play some role in the spectrum of
brain disorders ranging
from mood or anxiety to other problems that may include
autism, Parkinson's disease and multiple sclerosis.»
The
brains of children with
autism are relatively inflexible at switching
from rest to task performance, according to a new
brain - imaging study
from the Stanford University School of Medicine.
Certain
brain networks in children with
autism do not appear to change much when switching
from a resting state to engagement with a task, a new study finds.
The research comes
from the Infant
Brain Imaging Study (IBIS), a collaborative effort by investigators at the Montreal Neurological Institute, and four clinical sites in the United States, coordinated to conduct a longitudinal brain imaging and behavioural study of infants at high risk for au
Brain Imaging Study (IBIS), a collaborative effort by investigators at the Montreal Neurological Institute, and four clinical sites in the United States, coordinated to conduct a longitudinal
brain imaging and behavioural study of infants at high risk for au
brain imaging and behavioural study of infants at high risk for
autism.
A 2012 review
from Stanford researchers analyzed over 50 studies that used neuroimaging - that is, MRI, fMRI, magnetic resonance spectroscopy (MRS), diffusion tensor imaging (DTI), and anything else that takes before - and - after pictures of the
brain - to examine the
brains of kids with a variety of mental illnesses: anorexia, ADHD,
autism, bipolar disorder, depression, OCD, and schizophrenia.
In
autism, for example, his preliminary work suggests that there are more pronounced differences in
brain processing involved in distinguishing faces
from objects; in schizophrenia, there are greater differences related to decoding emotions.
Gradually he built up a picture of the autistic
brain from infancy to adulthood, zeroing in on a crucial distinction between those who have
autism and those who don't.
Schizophrenia is
from Venus,
Autism is
from Mars — There is a battle of the sexes raging in every person's
brain, as genes
from mom and dad fight for dominance.
So it can't just be genetic, prenatal, hardwired, and hopeless,» says Harvard pediatric neurologist Martha Herbert, author of a 14,000 - word paper in the journal Clinical Neuropsychiatry that reconceptualizes the universe of
autism, pulling the
brain down
from its privileged perch as an organ isolated
from the rest of the body.
Using data
from 58 of the 59 infants, the algorithm picked out the
brain connections that differ between children with and without
autism, and that track with scores on any of the behavioral tests.
A group of investigators
from San Diego State University's
Brain Development Imaging Laboratory are shedding a new light on the effects of autism on the b
Brain Development Imaging Laboratory are shedding a new light on the effects of
autism on the
brainbrain.
The algorithm then used the
brain activity data
from the 59th infant to predict whether she would later be diagnosed with
autism.
Autism is thought to result
from impaired connectivity in the
brain.
Researchers
from the MIND Institute at University of California, Davis, USA, found sex differences in children with
autism when looking at the organization of fibers in the corpus callosum, the largest bundle of nerve fibers in the
brain.2
It may be possible in future studies, he suggests, to determine whether children with developmental disorders like
autism have
brain structures that differ
from the norm in a similar way.
Dr Richard Bethlehem said: «This takes us one step closer to understanding why the
brains of people with and without
autism may differ
from one another.
The evidence
from MRI scans suggests that such Neanderthal - derived genetic variation may affect the way our
brains work today — and may hold clues to understanding deficits seen in schizophrenia and
autism - related disorders, say the researchers.
Now, a new study
from the research group EXPLORA of Ghent University shows for the first time that the
brain response to hearing one's own name is also diminished in adults with an
autism diagnosis.
Over the past few years, we have begun to see that the
brain is in constant dialogue with the immune system and even allows some foreign agents in — discoveries that are shedding new light on everything
from epilepsy and Alzheimer's disease to
autism.
Increasingly,
autism researchers are predicting that personalized, more effective treatments will come
from understanding these common
brain pathways — and how different gene variations alter them.
High firing rates could also impair the ability of the
brain to decode sensory stimuli, by causing an overwhelming response to even simple sensory stimuli; that could lead to
autism and the withdrawal
from social interactions.
The discovery may help explain why humans evolved more elaborate
brains than mice, and it could suggest ways to treat disorders such as
autism and epilepsy that arise
from abnormal neural development.
The mutation, which has been found in people with ADHD,
autism and bipolar disorder, affects the function of DAT, a protein that regulates the
brain's supply of the neurotransmitter by removing excess dopamine
from the synapse, or the space between nerve cells.
Using data
from blood and
brain tissue, a team led by researchers at Johns Hopkins Bloomberg School of Public Health found that they could gain insights into mechanisms that might help explain
autism by analyzing the interplay between genes and chemical tags that control whether genes are used to make a protein, called epigenetic marks.
Brain organoids, also known as mini-brains, are tiny clumps of brain cells grown from stem cells that researchers are using to investigate the neural underpinnings of autism and other neurological disor
Brain organoids, also known as mini-brains, are tiny clumps of
brain cells grown from stem cells that researchers are using to investigate the neural underpinnings of autism and other neurological disor
brain cells grown
from stem cells that researchers are using to investigate the neural underpinnings of
autism and other neurological disorders.
For example a next step is to scan premature babies and see how their myelin development differs
from babies born full term; and how connections in the
brains of babies who are at greater risk for developing
autism differ
from others.»
Children's Specialized Hospital is the nation's leading provider of inpatient and outpatient care for children
from birth to 21 years of age facing special health challenges —
from chronic illnesses and complex physical disabilities like
brain and spinal cord injuries, to developmental and behavioral issues like
autism and mental health.
Through his Multisensory Research Laboratory, VBI director Mark Wallace uses
brain imaging to better understand how the
brain «binds» together information
from sight and sound, and how changes in such binding may play a role in developmental disabilities such as
autism.
The only way to answer questions related to the fundamental genetic and neuropathological aspects of
autism spectrum disorder is to study
brain tissue
from individuals with
autism spectrum disorder.
Citation: Uddin LQ, Supekar K and Menon V (2013) Reconceptualizing functional
brain connectivity in
autism from a developmental perspective.
Although there is substantial evidence
from neuroimaging studies that the
brain of a child with
autism is undergoing abnormal development, little is known about the underlying cellular, molecular and genetic mechanisms that lead to the onset of autistic symptoms.
When created
from the stem cells of a patient with microcephaly, the
brains - in - a-dish resembled that often - fatal condition; those created
from cells of patients with severe
autism indicated that out - of - control neuron growth is the underlying cause of that disorder.
Results
from research reveals that oxytocin, a substance made naturally in the
brain as well as through the entire body, enhanced
brain function in areas which have been identified as processing social information in kids having
autism spectrum disorders.
With degenerative and cognitive - based diseases on the rise
from autism and ADHD in children to Parkison's and Alzheimer's in adults, uncovering the nuances in the relationship between the
brain and the gut has never been more important.
These nutrients help to maximize the intelligence of your child, and protect your baby
from brain injuries such as
autism, pervasive developmental delay, and ADHD.